A Prominent Role for Mucosal Cystine/Cysteine Metabolism in Intestinal Immunoregulation

Mucosal flora in inflammatory bowel disease

2002 • 1,344 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal -defensin expression

2004 • 795 citations

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

2005 • 785 citations

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

2005 • 751 citations

Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma

1992 • 503 citations

Crohn's disease

2002 • 486 citations

Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation

2002 • 481 citations

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

The Key Role of Macrophages in the Immunopathogenesis of Inflammatory Bowel Disease

2000 • 289 citations

Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes.

1994 • 270 citations

Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease

1997 • 239 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Isolation and phenotypic characterization of colonic macrophages

1998 • 184 citations

Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

1990 • 184 citations

Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa

1995 • 179 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

Intracellular Glutathione Levels in T Cell Subsets Decrease in HIV-Infected Individuals

1992 • 161 citations

Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine

1987 • 156 citations

Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system x c -

2001 • 150 citations

Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease

1991 • 137 citations

Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives

1991 • 131 citations

Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease

1995 • 127 citations

Multi-faceted regulation of ?-glutamylcysteine synthetase

2000 • 120 citations

Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response

1989 • 118 citations

Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

1997 • 116 citations

Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones

1991 • 107 citations

Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

1997 • 103 citations

Cytokine/chemokine messenger-RNA expression profiles in ulcerative colitis and Crohn's disease

2002 • 96 citations

Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation

1987 • 91 citations

Alterations of the phenotype of colonic macrophages in inflammatory bowel disease

1997 • 75 citations

Mechanisms of Natural Tolerance in the Intestine

2004 • 74 citations

Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content

1990 • 71 citations

Thiol-Mediated Redox Regulation of Intestinal Lamina Propria T Lymphocytes

2000 • 70 citations

Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease

1995 • 58 citations

The key role of macrophages in the immunopathogenesis of inflammatory bowel disease

2007 • 56 citations

Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine

1989 • 49 citations

Differential regulation of human T cell responsiveness by mucosal versus blood monocytes

1996 • 47 citations

“For Whom the Bell Tolls!” - Innate Defense Mechanisms and Survival Strategies of the Intestinal Epithelium Against Lumenal Pathogens

2002 • 42 citations

Ca2+ Signaling in Identified T-lymphocytes from Human Intestinal Mucosa

2004 • 34 citations

T cell receptor repertoire and mitotic responses of lamina propria T lymphocytes in inflammatory bowel disease

1994 • 23 citations

Phospholipid metabolism of lymphocytes with inhibited glutathione synthesis using L-buthionine-S,R-sulfoximine

1995 • 7 citations

[20] Redox processes regulate intestinal lamina propria T lymphocytes

2002 • 4 citations

Deleted Work

1955 • 0 citations