Metabotropic glutamate receptors are required for the induction of long-term potentiation

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

Long-term potentiation and NMDA receptors in rat visual cortex

1987 • 953 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Two components of long-term potentiation induced by different patterns of afferent activation

1990 • 704 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus

1991 • 319 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

1988 • 210 citations

Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus

1988 • 181 citations

Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition

1991 • 168 citations

1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons

1990 • 163 citations

Evidence that the commissural, associational and septal projections of the regio inferior of the hippocampus arise from the same neurons

1980 • 154 citations

Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action

1991 • 133 citations

Inhibition of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis in the Neonatal Rat Hippocampus by 2‐Amino‐3‐Phosphonopropionate

1989 • 114 citations

A Pertussis Toxin-Sensitive G Protein in Hippocampal Long-Term Potentiation

1989 • 114 citations

Long-term potentiation and activity-dependent retinotopic sharpening in the regenerating retinotectal projection of goldfish: common sensitive period and sensitivity to NMDA blockers.

1990 • 109 citations

2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus

1984 • 108 citations

Trans-ACPD enhances long-term potentiation in the hippocampus

1991 • 107 citations

(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.

1990 • 105 citations

Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.

1990 • 100 citations

Long-term potentiation and activity-dependent retinotopic sharpening in the regenerating retinotectal projection of goldfish: common sensitive period and sensitivity to NMDA blockers

1990 • 98 citations

2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus

1991 • 96 citations

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices

1991 • 89 citations

Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses

1991 • 86 citations

Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis

1991 • 86 citations

Trans-ACPD depresses synaptic transmission in the hippocampus

1991 • 75 citations

l-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brain

1990 • 74 citations

Intracellular recordings from rat dorsolateral septal neurons, in vitro

1984 • 71 citations

Metabotropic receptor-mediated long-term potentiation in rat hippocampal slices

1991 • 71 citations

In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor Effects

1991 • 66 citations

Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons

1988 • 66 citations

2-Amino-4-phosphonobutyrate selectively eliminates late phases of long-term potentiation in rat hippocampus

1989 • 65 citations

A direct nicotinic receptor-mediated inhibition recorded intracellularly in vitro

1989 • 59 citations

Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons

1991 • 57 citations

Vasopressin maintains long-term potentiation in rat lateral septum slices

1989 • 54 citations

A calcium-dependent slow afterdepolarization recorded in rat dorsolateral septal nucleus neurons in vitro

1990 • 48 citations

Trans-ACPD (trans-d,l-1-amino-1,3-cyclopentanedicarboxylic acid) elicited oscillation of membrane potentials in rat dorsolateral septal nucleus neurons recorded intracellularly in vitro

1991 • 47 citations

Inositol 1, 4, 5-trisphosphate 3-kinase distribution in the rat brain. High levels in the hippocampal CA1 pyramidal and cerebellar Purkinje cells suggest its involvement in some memory processes

1991 • 47 citations

In vitro studies of the role of γ‐aminobutyric acid in inhibition in the lateral septum of the rat

1987 • 45 citations

Bicuculline‐ and phaclofen‐sensitive components of N‐methyl‐D‐aspartate‐induced hyperpolarizations in rat dorsolateral septal nucleus neurones.

1989 • 25 citations

Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat

1991 • 23 citations

Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA

1990 • 20 citations

Burst firing of rat septal neurons induced by 1S,3R-ACPD requires influx of extracellular calcium

1992 • 18 citations