Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Methods in molecular biology

1991 • 938 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

In VitroEvidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSVtkRetroviral Gene Therapy

1993 • 425 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.

1994 • 298 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs.

1994 • 255 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer

1994 • 235 citations

Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

1992 • 222 citations

Treatment of hepatocellular carcinoma: too many options?

1994 • 201 citations

Hepatocellular carcinoma

1992 • 180 citations

Expression of Heterologous Sequences in Adenoviral Vectors

1992 • 171 citations

Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.

1994 • 163 citations

Gene therapy for cancer

1992 • 154 citations

Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.

1994 • 55 citations

Delayed Morbidity and Mortality of Albumin/SV40 T-Antigen Transgenic Mice after Insertion of an α-Fetoprotein/Herpes Virus Thymidine Kinase Transgene and Treatment with Ganciclovir

1994 • 39 citations

Generation of a Transgenic Model for Retrovirus-Mediated Gene Therapy for Hepatocellular Carcinoma Is Thwarted by the Lack of Transgene Expression

1993 • 37 citations

Retroviral Delivery of DNA into the Livers of Transgenic Mice Bearing Premalignant and Malignant Hepatocellular Carcinomas

1994 • 22 citations

Gene therapy for cancer

1995 • 19 citations

Gene therapy for cancer

1994 • 14 citations