Treatment of hepatocellular carcinoma: too many options?

The blood supply of neoplasms in the liver.

1954 • 1,280 citations

Risk Factors for Hepatocellular Carcinoma among Patients with Chronic Liver Disease

1993 • 1,118 citations

Liver Resection Versus Transplantation for Hepatocellular Carcinoma in Cirrhotic Patients

1993 • 884 citations

Hepatocellular Carcinoma in Italian Patients with Cirrhosis

1991 • 832 citations

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

1993 • 725 citations

Hepatic Resection Versus Transplantation for Hepatocellular Carcinoma

1991 • 673 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

2001 • 644 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Des-γ-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma

1984 • 576 citations

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates

1993 • 545 citations

Role of Liver Transplantation in Cancer Therapy

1985 • 504 citations

Pharmacologic rationale for regional drug delivery.

1984 • 451 citations

Primary Liver Cancer in Japan

1992 • 438 citations

Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications

1985 • 431 citations

Percutaneous etharrol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients

1992 • 408 citations

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

1991 • 385 citations

A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584.

1991 • 383 citations

The Role of Liver Transplantation in Hepatobiliary Malignancy. A Retrospective Analysis of 95 Patients with Particular Regard to Tumor Stage and Recurrence

1989 • 376 citations

US-guided percutaneous alcohol injection of small hepatic and abdominal tumors.

1986 • 373 citations

Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study

1991 • 322 citations

Detection of focal hepatic masses: prospective evaluation with CT, delayed CT, CT during arterial portography, and MR imaging.

1989 • 321 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma—A randomized controlled trial

1988 • 292 citations

Primary treatment of hepatocellular carcinoma by arterial chemoembolization

1992 • 269 citations

Ultrasound-guided hepatic cryosurgery in the treatment of metastatic colon carcinoma. Preliminary results

1991 • 266 citations

Iodine 131 antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group study.

1985 • 259 citations

Prognostic factors of hepatocellular carcinoma in the west: A multivariate analysis in 206 patients

1990 • 233 citations

Recombinant interferon-α in inoperable hepatocellular carcinoma: A randomized controlled trial

1993 • 224 citations

HEPATIC TRANSPLANTATION IN EUROPE

1987 • 221 citations

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.

1992 • 221 citations

Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. An analysis by the cox proportional hazard model

1991 • 215 citations

Pharmacokinetics and Tissue Distribution of Doxorubicin Encapsulated in Stable Liposomes With Long Circulation Times

1989 • 210 citations

Tumor heterogeneity and drug resistance.

1986 • 210 citations

Prevention of Perinatal Acquisition of Hepatitis B Virus Carriage Using Vaccine: Preliminary Report of a Randomized, Double-Blind Placebo-Controlled and Comparative Trial

1985 • 206 citations

Transcatheter hepatic segmental arterial embolization using lipiodol mixed with an anticancer drug and gelfoam particles for hepatocellular carcinoma

1990 • 205 citations

Neoadjuvant chemotherapy and liver transplantation for hepatocellular carcinoma: A pilot study in 20 patients

1993 • 199 citations

Angiographic classification of hepatic arterial collaterals.

1982 • 190 citations

Is Liver Transplantation Justified for the Treatment of Hepatic Malignancies?

1990 • 188 citations

α-fetoprotein monitoring in chinese patients with chronic hepatitis B virus infection: Role in the early detection of hepatocellular carcinoma

1989 • 185 citations

Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer

1983 • 180 citations

Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy.

1993 • 180 citations

Transcatheter chemo-embolization effective for treating hepatocellular carcinoma. A histopathologic study

1984 • 180 citations

Clinical evaluation of cryosurgery in the treatment of primary liver cancer Report of 60 Cases

1988 • 173 citations

Patterns of intrahepatic recurrence after curative resection of hepatocellular carcinoma

1989 • 166 citations

Chemoembolization for hepatocellular carcinoma.

1990 • 160 citations

Serum alphafetoprotein in hepatocellular carcinoma

1977 • 153 citations

Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: results of a Western comparative study in 60 patients.

1991 • 145 citations

Detection of malignant tumors in end-stage cirrhotic livers: efficacy of sonography as a screening technique.

1992 • 144 citations

Hepatic artery injection of I-131-labeled lipiodol. Part I. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases.

1988 • 144 citations

LIVER TRANSPLANTATION FOR PRIMARY HEPATIC CANCER1

1992 • 134 citations

An application of dose volume histograms to the treatment of intrahepatic malignancies with radiation therapy

1990 • 125 citations

Etiology, pathology, and treatment of hepatocellular carcinoma in North America

1991 • 123 citations

Phase I-II studies of yttrium-labeled antiferritin treatment for end-stage Hodgkin's disease, including Radiation Therapy Oncology Group 87-01.

1991 • 123 citations

Primary liver cancer. An eastern cooperative oncology group trial

1984 • 120 citations

Liver Transplantation for Malignant Disease

1991 • 119 citations

Islet Cell Tumors Metastatic to the Liver: Effective Palliation by Sequential Hepatic Artery Embolization

1988 • 119 citations

Hepatic Resection in 120 Patients With Hepatocellular Carcinoma

1989 • 118 citations

Unresectable hepatocellular carcinoma: a prospective controlled trial with tamoxifen

1990 • 115 citations

Hepatoma in the noncirrhotic liver

1988 • 115 citations

Asymptomatic hepatocellular carcinoma in Child's A cirrhosis

1989 • 115 citations

Do the tumor cells of hepatocellular carcinomas dislodge into the portal venous stream during hepatic resection?

1992 • 112 citations

Induction of remission in hepatocellular carcinoma: A comparison of VP 16 with adriamycin

1983 • 109 citations

The role of liver transplantation in hepatobiliary malignancy

1989 • 108 citations

Lidocaine Metabolite Formation as a Measure of Liver Function in Patients with Cirrhosis

1990 • 106 citations

Results of hepatic resection and transplantation for fibrolamellar carcinoma.

1992 • 104 citations

Effects of hepatic arterial yttrium 90 glass microspheres in dogs

1988 • 100 citations

Treatment of fibrolamellar hepatoma with partial or total hepatectomy and transplantation of the liver.

1986 • 97 citations

Treatment of hepatocellular carcinoma using doxorubicin/ethiodized oil/gelatin powder chemoembolization

1993 • 96 citations

Hepatomas: hormone receptors and therapy.

1982 • 86 citations

Intrahepatic chemotherapy for unresectable hepatocellular carcinoma

1988 • 84 citations

Adverse effects of preoperative hepatic artery chemoembolization for resectable hepatocellular carcinoma: a retrospective comparison of 138 liver resections.

1989 • 83 citations

Surgery for Hepatic Neoplasms

1985 • 81 citations

Transcatheter arterial embolization in unresectable hepatocellular carcinoma

1990 • 81 citations

Society of Gastrointestinal Radiologists Roscoe E. Miller Award. Monitoring hepatic cryosurgery with sonography

1986 • 80 citations

Internal radiation therapy for hepatocellular carcinoma. Results of a french multicenter phase II trial of transarterial injection of iodine 131-labeled lipiodol

1992 • 78 citations

Low Incidence of Point Mutation of c‐Ki‐ras and N‐ras Oncogenes in Human Hepatocellular Carcinoma

1989 • 75 citations

[Percutaneous ethanol injection therapy for hepatocellular carcinoma].

1990 • 74 citations

Dosimetry of 131I-labeled antiferritin in hepatoma: specific activities in the tumor and liver.

1983 • 71 citations

Workshop on Screening for Hepatocellular Carcinoma

1991 • 70 citations

The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the α-fetoprotein status

1993 • 70 citations

Treatment of unresectable primary liver cancer with intrahepatic fluorodeoxyuridine and mitomycin C through an implantable pump

1992 • 66 citations

A comparative study of hepatic resection and transcatheter arterial embolization for the treatment of primary hepatocellular carcinoma

1993 • 62 citations

A phase II trial of tamoxifen in hepatocellular carcinoma

1990 • 61 citations

Prolonged survival after liver transplantation and cancer chemotherapy for advanced-stage hepatocellular carcinoma.

1993 • 61 citations

Hepatic artery ligation and postoperative chemotherapy for hepatic metastases: Clinical and pathophysiological results

1975 • 57 citations

A randomized prospective trial comparing full dose chemotherapy to 131I antiferritin: An RTOG study

1991 • 55 citations

Binding to and internalization by cultured cells of neocarzinostatin and enhancement of its actions by conjugation with lipophilic styrene-maleic acid copolymer.

1987 • 54 citations

Conversion by new treatment modalities of nonresectable to resectable hepatocellular cancer.

1987 • 54 citations

Experience with transplantation in the treatment of liver cancer

1989 • 53 citations

Lipiodol computerized tomography: how sensitive and specific is the technique in the diagnosis of hepatocellular carcinoma?

1990 • 52 citations

Prediction of relapse or survival after resection in human hepatomas by DNA flow cytometry.

1992 • 50 citations

Liver and tumor uptake and plasma pharmacokinetic of arterial cisplatin administered with and without starch microspheres in patients with liver metastases

1991 • 50 citations

A new approach to chemoembolization for unresectable hepatocellular carcinoma using aclarubicin microspheres in combination with cisplatin suspended in iodized oil

1991 • 49 citations

Can determination of the proliferative capacity of the nontumor portion predict the risk of tumor recurrence in the liver remnant after resection of human hepatocellular carcinoma?

1993 • 47 citations

Anticancer effects of arterial administration of the anticancer agent SMANCS with lipiodol on metastatic lymph nodes

1987 • 44 citations

Cost-benefit analysis of a nationwide neonatal inoculation programme against hepatitis B in an area of intermediate endemicity.

1992 • 42 citations

Collagen chemoembolization: pharmacokinetics and tissue tolerance of cis-diamminedichloroplatinum(II) in porcine liver and rabbit kidney.

1988 • 41 citations

Combined doxorubicin and alpha-interferon therapy of advanced hepatocellular carcinoma

1993 • 41 citations

A pre-operative chemoembolization therapy using lipiodol, cisplatin and gelatin sponge for hepatocellular carcinoma

1989 • 40 citations

Transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma

1992 • 38 citations

Design and compliance of HBV vaccination trial on newborns to prevent hepatocellular carcinoma and 5-year results of its pilot study.

1991 • 37 citations

Screening for Hepatocellular Carcinoma in High-Risk Individuals

1989 • 37 citations

Liver transplantation in the United States: 1988 to 1990.

1991 • 36 citations

Variables affecting the tumor localization of131 I-antiferritin in experimental hepatoma

1984 • 36 citations

Pharmacokinetics of Intra-Arterial Mitomycin C With or Without Degradable Starch Microspheres (DSM) in the Treatment of Non-Resectable Liver Cancer

1989 • 36 citations

Phase II study of mitoxantrone in unresectable primary hepatocellular carcinoma following hepatitis B infection

1989 • 32 citations

Early detection of hepatocellular carcinoma in patients with cirrhosis by alphafetoprotein, ultrasound and fine-needle biopsy.

1989 • 30 citations

hepatic arterial embolization with microencapsulated mitomycin C for unresectable hepatocellular carcinoma in cirrhosis

1990 • 26 citations

Liver transplantation for hepatocellular carcinoma Stone MJ, Klintmalm GBG, Polter D, Husberg BS, Mennel RG, Ramsay MAE, Flemens EE, Goldstein RM. Neoadjuvant chemotherapy and liver transplantation for hepatocellular carcinoma: a pilot study in 20 patients. Gastroenterology 1993; 104: 196–202

1993 • 26 citations

Prevention of hepatitis B virus carriage of infants using HBV vaccine in Shanghai. Preliminary report of a randomized double-blind placebo-controlled trial.

1985 • 25 citations

Treatment of hepatocellular carcinoma associated with advanced cirrhosis by transcatheter arterial chemoembolization using autologous blood clot: A preliminary report

1992 • 23 citations

Arterial infusion chemotherapy for advanced hepatocellular carcinoma using EPF and EAP therapies

1992 • 22 citations

Liver resection in malignant disease

1987 • 21 citations

Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma

1991 • 18 citations

Lipiodol drug targeting in the treatment of primary hepatocellular carcinoma.

1990 • 15 citations

Clinical evaluation of transcatheter arterial embolization and one-shot chemotherapy in hepatocellular carcinoma.

1988 • 13 citations

Early diagnosis of hepatocellular carcinoma.

1990 • 13 citations

Can liver transplantation be applied for the treatment of liver cancer?

1992 • 7 citations

A decade's studies on the immunotargeting therapy of hepatocellular carcinoma

1993 • 5 citations