Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

2001 • 1,271 citations

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system

1988 • 1,235 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through G_i/o-Coupled P2Y Receptors

2001 • 549 citations

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

2002 • 492 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

1997 • 477 citations

P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

2003 • 470 citations

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

1987 • 407 citations

Vanilloid receptor 1 immunoreactivity in inflamed human bowel

2001 • 356 citations

Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor.

1990 • 348 citations

Nitric Oxide Signaling in Pain and Nociceptor Sensitization in the Rat

1998 • 262 citations

ATP-stimulated Release of Interleukin (IL)-1β and IL-18 Requires Priming by Lipopolysaccharide and Is Independent of Caspase-1 Cleavage

2001 • 259 citations

Reanalysis of P2X₇Receptor Expression in Rodent Brain

2004 • 257 citations

Chronic Pain Prevalence and Analgesic Prescribing in a General Medical Population

2002 • 246 citations

ATP Mediates Calcium Signaling Between Astrocytes and Microglial Cells: Modulation by IFN-γ

2001 • 232 citations

Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation

1996 • 232 citations

Blockade of Human P2X7 Receptor Function With a Monoclonal Antibody

1998 • 196 citations

Pharmacological characterization of ATP‐ and LPS‐induced IL‐1β release in human monocytes

1999 • 148 citations

Cloning and functional characterisation of the mouse P2X₇ receptor

1998 • 146 citations

Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

1999 • 118 citations

Ionic effects on human recombinant P2X7 receptor function

1999 • 118 citations

Maturation and Release of Interleukin-1β by Lipopolysaccharide-primed Mouse Schwann Cells Require the Stimulation of P2X7 Receptors

2003 • 103 citations

Differential Assembly of Rat Purinergic P2X7 Receptor in Immune Cells of the Brain and Periphery

2001 • 103 citations

Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos.

1990 • 97 citations

Ecto-Nucleotidases and Nucleoside Transporters Mediate Activation of Adenosine Receptors on Hippocampal Mossy Fibers by P2X₇Receptor Agonist 2′-3′-O-(4-Benzoylbenzoyl)-ATP

2004 • 86 citations

Novel P2X7 receptor antagonists

2003 • 58 citations

Immunohistochemical identification of cells expressing ATP‐gated cation channels (P2X receptors) in the adult rat thyroid

2001 • 56 citations

Determination of changes in mRNA expression in a rat model of neuropathic pain by Taqman™ quantitative RT-PCR

2001 • 46 citations

Inhibition of inducible nitric oxide synthase in persistent pain

1999 • 35 citations

Validation of the dual channel weight averager as an instrument of the measurement of clinically relevant pain

1997 • 18 citations

Inactivation in vivo of metabotropic glutamate receptor 1 by specific chromosomal insertion of reporter gene LacZ

1995 • 10 citations

A guide to drug evaluation for chronic pain

2000 • 8 citations

Emerging drugs for neuropathic pain

2001 • 8 citations