Exocytosis: SNAREs drum up!

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1997 • 673 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Multiple calcium-dependent processes related to secretion in bovine chromaffin cells

1993 • 524 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

Complexins: Cytosolic proteins that regulate SNAP receptor function

1995 • 494 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

The role of Rab3A in neurotransmitter release

1994 • 481 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1995 • 455 citations

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

1996 • 439 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

Protein Kinase C Enhances Exocytosis from Chromaffin Cells by Increasing the Size of the Readily Releasable Pool of Secretory Granules

1996 • 395 citations

Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila

1995 • 389 citations

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

1997 • 360 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

Kinetics of the secretory response in bovine chromaffin cells following flash photolysis of caged Ca2+

1994 • 343 citations

Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis

1992 • 340 citations

The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling.

1995 • 338 citations

Clostridial neurotoxins: new tools for dissecting exocytosis

1994 • 323 citations

A Ca-Dependent Early Step in the Release of Catecholamines from Adrenal Chromaffin Cells

1993 • 312 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

Inhibition of Neurotransmission by Peptides Containing the Synaptic Protein Interaction Site of N-Type Ca2+ Channels

1996 • 290 citations

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

1994 • 288 citations

Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins.

1992 • 286 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles

1997 • 275 citations

Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.

1996 • 273 citations

rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin.

1995 • 269 citations

The Mammalian Brain rsec6/8 Complex

1996 • 263 citations

Phosphorylation of Munc-18/n-Sec1/rbSec1 by Protein Kinase C

1996 • 262 citations

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

1995 • 262 citations

A post-docking role for synaptobrevin in synaptic vesicle fusion

1994 • 255 citations

Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis

1991 • 251 citations

Phosphorylation of 25-kDa Synaptosome-associated Protein

1996 • 248 citations

Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch

1997 • 244 citations

A low affinity Ca2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs

1993 • 243 citations

Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells

1995 • 241 citations

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle.

1994 • 240 citations

Docking of Yeast Vacuoles Is Catalyzed by the Ras-like GTPase Ypt7p after Symmetric Priming by Sec18p (NSF)

1997 • 239 citations

Nitric Oxide Modulates Synaptic Vesicle Docking/Fusion Reactions

1996 • 238 citations

Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells.

1994 • 227 citations

Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells.

1994 • 224 citations

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.

1995 • 223 citations

Synaptic vesicle membrane proteins interact to form a multimeric complex.

1992 • 219 citations

The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendocrine cells.

1994 • 213 citations

Protein Interactions Regulating Vesicle Transport between the Endoplasmic Reticulum and Golgi Apparatus in Mammalian Cells

1997 • 213 citations

H+-induced Membrane Insertion of Influenza Virus Hemagglutinin Involves the HA2 Amino-terminal Fusion Peptide but Not the Coiled Coil Region

1996 • 211 citations

The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin

1995 • 210 citations

Common and distinct fusion proteins in axonal growth and transmitter release

1996 • 209 citations

MgATP-independent and MgATP-dependent Exocytosis

1989 • 209 citations

Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct components.

1992 • 208 citations

N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis

1996 • 206 citations

Ypt1p implicated in v-SNARE activation

1994 • 199 citations

A Novel Function for the Second C2 Domain of Synaptotagmin

1996 • 197 citations

Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules.

1990 • 195 citations

Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis.

1995 • 187 citations

Ca2+ and secretory-vesicle dynamics

1995 • 185 citations

Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex.

1996 • 185 citations

A possible docking and fusion particle for synaptic transmission

1995 • 177 citations

Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity -SNAP Binding Site

1995 • 174 citations

DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion

1997 • 168 citations

Syntaxin 5 regulates endoplasmic reticulum to Golgi transport.

1994 • 153 citations

Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion.

1995 • 150 citations

SNAP-25 Is Required for a Late Postdocking Step in Ca2+-dependent Exocytosis

1996 • 148 citations

SNAP-mediated protein–protein interactions essential for neurotransmitter release

1995 • 146 citations

The V Sector of the V-ATPase, Synaptobrevin, and Synaptophysin Are Associated on Synaptic Vesicles in a Triton X-100-resistant, Freeze-thawing Sensitive, Complex

1996 • 141 citations

Interaction of SNARE Complexes with P/Q-type Calcium Channels in Rat Cerebellar Synaptosomes

1996 • 138 citations

GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport

1996 • 138 citations

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.

1996 • 136 citations

Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons

1996 • 133 citations

Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin

1995 • 132 citations

The α-Ca2+/calmodulin kinase II: A bidirectional modulator of presynaptic plasticity

1995 • 130 citations

Ca2+ triggers massive exocytosis in Chinese hamster ovary cells.

1996 • 129 citations

Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells.

1995 • 125 citations

Hrs-2 is an ATPase implicated in calcium-regulated secretion

1997 • 120 citations

In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae.

1992 • 113 citations

Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles.

1990 • 106 citations

A v-SNARE implicated in intra-Golgi transport.

1996 • 104 citations

Synaptic plasticity: A role for nitric oxide in LTP

1997 • 104 citations

Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release

1994 • 101 citations

Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis.

1996 • 100 citations

Phosphorylation of VAMP/Synaptobrevin in Synaptic Vesicles by Endogenous Protein Kinases

1995 • 100 citations

A role for soluble NSF attachment proteins (SNAPs) in regulated exocytosis in adrenal chromaffin cells.

1995 • 99 citations

Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A.

1992 • 93 citations

A biosynthetic regulated secretory pathway in constitutive secretory cells.

1996 • 89 citations

A synaptobrevin–like gene in the Xq28 pseudoautosomal region undergoes X inactivation

1996 • 87 citations

Casein kinase II phosphorylates the synaptic vesicle protein p65

1993 • 87 citations

Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.

1995 • 86 citations

Protein phosphorylation and secretion in digitonin-permeabilized adrenal chromaffin cells. Effects of micromolar Ca2+, phorbol esters, and diacylglycerol.

1986 • 85 citations

Mammalian Sly1 Regulates Syntaxin 5 Function in Endoplasmic Reticulum to Golgi Transport

1996 • 84 citations

Ca2+-dependent Exocytotic Pathways in Chinese Hamster Ovary Fibroblasts Revealed by a Caged-Ca2+ Compound

1996 • 83 citations

The Secretory Granule Protein Syncollin Binds to Syntaxin in a Ca2+-Sensitive Manner

1997 • 82 citations

Covalent modification of synapsin I by a tetanus toxin-activated transglutaminase.

1993 • 81 citations

Long-term potentiation and synaptic protein phosphorylation

1995 • 76 citations

Apobec-1 Interacts with a 65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro

1996 • 75 citations

Ca(2+)-dependent conformational change in synaptotagmin I.

1994 • 74 citations

Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles.

1996 • 73 citations

Demonstration of presynaptic protein kinase C activation following long-term potentiation in rat hippocampal slices

1993 • 70 citations

Rab3 proteins: key players in the control of exocytosis

1994 • 65 citations

Tetanus toxin potently stimulates tissue transglutaminase. A possible mechanism of neurotoxicity.

1992 • 58 citations

The GTPase Rab3a is associated with large dense core vesicles in bovine chromaffin cells and rat PC12 cells

1995 • 57 citations

Evidence for a functional link between Rab3 and the SNARE complex

1996 • 55 citations

Calcium‐Dependent Self‐Association of Synaptotagmin I

1996 • 55 citations

Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis.

1997 • 52 citations

Tetanus Toxin Inhibits Neuroexocytosis Even When Its Zn2+-dependent Protease Activity Is Removed

1995 • 45 citations

Inhibition of Transmitter Release Correlates with the Proteolytic Activity of Tetanus Toxin and Botulinus Toxin A in Individual Cultured Synapses ofHirudo medicinalis

1997 • 39 citations

Presynaptic events involved in neurotransmission

1993 • 35 citations

Crystallization and Preliminary X-ray Analysis of a Low Density Lipoprotein from Human Plasma

1996 • 34 citations

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings

1992 • 33 citations

Substrate residues N‐terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity

1996 • 33 citations