Molecular aspects of membrane fission in the secretory pathway

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

SNARE-mediated membrane fusion

2001 • 1,121 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function

1987 • 729 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Dynamin and Its Role in Membrane Fission

2000 • 689 citations

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

1998 • 665 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells

1998 • 603 citations

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

2001 • 589 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

An essential role for a phospholipid transfer protein in yeast Golgi function

1990 • 534 citations

CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis

2002 • 527 citations

Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells

1997 • 469 citations

Effects of mutant rat dynamin on endocytosis

1993 • 453 citations

GTPase activity of dynamin and resulting conformation change are essential for endocytosis

2001 • 451 citations

The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

1998 • 431 citations

Lipids in biological membrane fusion

1995 • 431 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane

2002 • 408 citations

The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

1997 • 383 citations

The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex.

1989 • 381 citations

Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring

1999 • 380 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS

1995 • 371 citations

Regulation of phospholipase D

1999 • 369 citations

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

1995 • 361 citations

Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity

1997 • 354 citations

Generation of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes

1998 • 345 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.

1983 • 332 citations

Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis

1999 • 328 citations

Spectrin tethers and mesh in the biosynthetic pathway

2000 • 326 citations

CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid

1999 • 325 citations

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators

1998 • 320 citations

Role of Dynamin in the Formation of Transport Vesicles from the Trans-Golgi Network

1998 • 318 citations

Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons

1998 • 312 citations

Fission and Uncoating of Synaptic Clathrin-Coated Vesicles Are Perturbed by Disruption of Interactions with the SH3 Domain of Endophilin

2000 • 297 citations

Dynamin 2 Is Required for Phagocytosis in Macrophages

1999 • 283 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D

1999 • 275 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells

1999 • 258 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein

2000 • 239 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Dynamin at actin tails

2002 • 236 citations

Implications of lipid microdomains for membrane curvature, budding and fission

2001 • 233 citations

Dynamin:Gtp Controls the Formation of Constricted Coated Pits, the Rate Limiting Step in Clathrin-Mediated Endocytosis

2000 • 232 citations

The shape of lipid molecules and monolayer membrane fusion

1985 • 226 citations

The large GTPase dynamin regulates actin comet formation and movement in living cells

2002 • 224 citations

Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection

2002 • 224 citations

Protein kinase D: an intracellular traffic regulator on the move

2002 • 221 citations

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

2000 • 215 citations

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

1998 • 208 citations

Fatty acyl-coenzyme a is required for budding of transport vesicles from Golgi cisternae

1989 • 204 citations

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

1998 • 200 citations

A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules

1991 • 188 citations

A role for phosphatidylinositol transfer protein in secretory vesicle formation

1995 • 186 citations

The CtBP family: enigmatic and enzymatic transcriptional co‐repressors

2001 • 183 citations

Intracellular Localization of Phospholipase D1 in Mammalian Cells

2001 • 183 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Dynamin

1998 • 172 citations

Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase

1995 • 170 citations

Physical properties and functional roles of lipids in membranes

1996 • 169 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

Lipids of the Golgi membrane

1998 • 168 citations

Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain

2001 • 166 citations

Variations on the Intracellular Transport Theme: Maturing Cisternae and Trafficking Tubules

1997 • 144 citations

Synaptojanin Forms Two Separate Complexes in the Nerve Terminal

1997 • 138 citations

Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin

2000 • 137 citations

Cloning and Characterization of Phospholipase D from Rat Brain

1997 • 137 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

Evidence that phospholipase A ₂ activity is required for Golgi complex and trans Golgi network membrane tubulation

1998 • 136 citations

Greasing Membrane Fusion and Fission Machineries

2000 • 132 citations

Correlation between secretion and phospholipase D activation in differentiated HL60 cells

1993 • 129 citations

Lipids, lipid modification and lipid–protein interaction in membrane budding and fission — insights from the roles of endophilin A1 and synaptophysin in synaptic vesicle endocytosis

2000 • 122 citations

Synaptojanin Inhibition of Phospholipase D Activity by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

1997 • 120 citations

Regulation of Golgi Structure through Heterotrimeric G Proteins

1997 • 117 citations

Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells

2000 • 115 citations

Golgi Vesicle Proteins Are Linked to the Assembly of an Actin Complex Defined by mAbp1

2002 • 114 citations

Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus

1999 • 107 citations

Protein kinase C mu is located at the Golgi compartment.

1996 • 105 citations

Lipid polymorphism and membrane properties

1997 • 104 citations

Molecular Cloning and Functional Characterization of Brefeldin A-ADP-ribosylated Substrate

1999 • 97 citations

Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase

1998 • 97 citations

Three-dimensional structure of the Golgi apparatus in mammalian cells

1997 • 96 citations

Membrane Fusion Mechanisms: The Influenza Hemagglutinin Paradigm and its Implications for Intracellular Fusion

2000 • 94 citations

Golgi Membrane Dynamics

1998 • 87 citations

A Phosphatidylinositol 3-Kinase and Phosphatidylinositol Transfer Protein Act Synergistically in Formation of Constitutive Transport Vesicles from the Trans-Golgi Network

1998 • 86 citations

The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity.

1996 • 85 citations

Phosphatidylinositol transfer proteins: the long and winding road to physiological function

1998 • 79 citations

Phospholipase D2 Directly Interacts with Aldolase via Its PH Domain

2002 • 78 citations

Stimulation of endogenous ADP-ribosylation by brefeldin A.

1994 • 75 citations

A Novel C-Terminal Binding Protein (CTBP2) Is Closely Related toCTBP1,an Adenovirus E1A-Binding Protein, and Maps to Human Chromosome 21q21.3

1998 • 72 citations

Membrane Tubule-mediated Reassembly and Maintenance of the Golgi Complex Is Disrupted by Phospholipase A₂Antagonists

1999 • 72 citations

Type Iα phosphatidylinositol 4‐phosphate 5‐kinase is a putative target for increased intracellular phosphatidic acid

2000 • 70 citations

Mitochondrial division: New partners in membrane pinching

2001 • 69 citations

Colocalization of phospholipase D1 and GTP‐binding‐defective mutant of ADP‐ribosylation factor 6 to endosomes and lysosomes

1999 • 67 citations

Inhibition of Phospholipase D by Amphiphysins

2000 • 64 citations

Participation of dynamin in the biogenesis of cytoplasmic vesicles

1999 • 60 citations

Inhibition of Phospholipase D by Clathrin Assembly Protein 3 (AP3)

1997 • 60 citations

The in Vitro Generation of Post-Golgi Vesicles Carrying Viral Envelope Glycoproteins Requires an ARF-like GTP-binding Protein and a Protein Kinase C Associated with the Golgi Apparatus

1996 • 59 citations

Phosphatidylinositol/phosphatidylcholine transfer proteins in yeast

2000 • 57 citations

Anterograde transport through the Golgi complex: do Golgi tubules hold the key?

1995 • 55 citations

Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex.

1995 • 53 citations

Role of NAD+ and ADP-Ribosylation in the Maintenance of the Golgi Structure

1997 • 52 citations

Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN – phosphoinositides as a common denominator?

1997 • 51 citations

Subcellular Organization of Receptor-Mediated Phosphoinositide Turnover*

1992 • 50 citations

An essential role for the phosphatidylinositol transfer protein in the scission of coatomer-coated vesicles from the trans-Golgi network

1998 • 50 citations

Monolayer characterstics and thermal behaviour of phosphatidic acids

1992 • 48 citations

Effects of Activated ADP-ribosylation Factors on Golgi Morphology Require neither Activation of Phospholipase D1 nor Recruitment of Coatomer

2000 • 42 citations

Characterization of Chemical Inhibitors of Brefeldin A-activated Mono-ADP-ribosylation

1997 • 37 citations

The contribution of lipids and lipid metabolism to cellular functions of the Golgi complex

1998 • 36 citations

Regulation of Constitutive Protein Transit by Phospholipase D in HT29-cl19A Cells

2001 • 34 citations

The Role of Phosphatidylinositol Transfer Proteins (PITPs) in Intracellular Signalling

1998 • 12 citations

Chapter 11 Morphology of Membrane Fusion

1997 • 8 citations

Cell-free reconstitution of the transport of viral glycoproteins from the TGN to the basolateral plasma membrane of MDCK cells

1996 • 7 citations

Role of brefeldin A-dependent ADP-ribosylation in the control of intracellular membrane transport.

1999 • 5 citations