A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

1966 • 831 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

1994 • 587 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

1989 • 417 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

1997 • 399 citations

SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae

1996 • 380 citations

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

1988 • 282 citations

Escherichia coli RecQ protein is a DNA helicase.

1990 • 263 citations

Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA

1991 • 228 citations

The Yeast Type I Topoisomerase Top3 Interacts with Sgsl, a DNA Helicase Homolog: a Potential Eukaryotic Reverse Gyrase

1994 • 209 citations

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1996 • 201 citations

Genetic linkage of Werner's syndrome to five markers on chromosome 8

1992 • 200 citations

Targeted Disruption of the Mouse Topoisomerase I Gene by Camptothecin Selection

1996 • 175 citations

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

1993 • 167 citations

The gene responsible for Werner syndrome may be a cell division "counting" gene.

1993 • 157 citations

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

1997 • 146 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

1996 • 136 citations

Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes

1994 • 112 citations

Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

1981 • 109 citations

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients

1990 • 87 citations

Differential Effects of Cytotoxic Drugs on Mortal and Immortalized B-Lymphoblastoid Cell Lines from Normal and Werner's Syndrome Patients.

1998 • 71 citations

A 17S multiprotein form of murine cell DNA polymerase mediates polyomavirus DNA replication in vitro

1994 • 50 citations

Fragmentation of centromeric DNA and prevention of homologous chromosome separation in male mouse meiosis in vivo by the topoisomerase II inhibitor etoposide

1996 • 50 citations

Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects

1989 • 48 citations

Immortalization of Werner syndrome and progeria fibroblasts

1991 • 46 citations

Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.

1996 • 45 citations

Werner's syndrome: proliferation in vitro of clones of cells bearing chromosome translocations.

1984 • 45 citations

Effects of topoisomerase II inhibition in lymphoblasts from patients with progeroid and “chromosome instability” syndromes

1996 • 36 citations

Werner’s Syndrome Associated with Malignancies:Five Case Reports with a Survey of Case Histories in Japan

1988 • 34 citations

Elevated spontaneous mutation rate in SV40-transformed werner syndrome fibroblast cell lines

1985 • 33 citations

Cloning of a Mouse Homologue of the Human Werner Syndrome Gene and Assignment to 8A4 by Fluorescencein SituHybridization

1997 • 29 citations

Mutagenic consequences of the incorporation of 6-thioguanine into DNA

1997 • 25 citations

Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome.

1990 • 23 citations

Establishment and Characterization of Testicular Cell Lines from MT-PVLT-10 Transgenic Mice

1994 • 17 citations

Effects of incorporation of 6-thioguanine into SV40 DNA.

1987 • 17 citations

Narrowing the Position of the Werner Syndrome Locus by Homozygosity Analysis—Extension of Homozygosity Analysis

1996 • 8 citations