Differential Mechanisms of Cytochrome P450 Inhibition and Activation by α-Naphthoflavone

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Plant Flavonoids in Biology and Medicine, Biochemical, Pharmacological and Structure-Activity Relationships

1986 • 562 citations

Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia

1991 • 453 citations

Diet in the Epidemiology of Cancer of the Colon and Rectum<xref ref-type="fn" rid="FN2">2</xref>

1978 • 423 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

1994 • 348 citations

Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

1990 • 330 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.

1981 • 290 citations

Vegetable Consumption and Lung Cancer Risk: A Population-Based Case-Control Study in Hawaii

1989 • 282 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

1992 • 230 citations

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

1989 • 221 citations

Role of chemopreventers in human diet

1994 • 211 citations

Inhibition of the carcinogenic action of benzo(a)pyrene by flavones.

1970 • 210 citations

Oxidation of Benzo[a]pyrene by Recombinant Human Cytochrome P450 Enzymes

1995 • 210 citations

Plant flavonoids in biology and medicine: Biochemical, pharmacological, and structure-activity relationships

1985 • 199 citations

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids

1983 • 196 citations

Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase

1969 • 185 citations

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.

1992 • 177 citations

Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity

1995 • 172 citations

Induction of Cytochrome P4501 as an Indicator of Potential Chemical Carcinogenesis

1993 • 135 citations

Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids

1994 • 112 citations

Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding

1972 • 110 citations

Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.

1992 • 93 citations

CO Binding Kinetics of Human Cytochrome P450 3A4

1995 • 88 citations

cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.

1994 • 83 citations

A preliminary structure-activity study of the mixed-function oxidase inhibitor, 7,8-benzoflavone

1979 • 73 citations

Activation of monooxygenases in human liver by 7,8‐benzoflavone

1977 • 66 citations

Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c.

1988 • 61 citations

Effects of synthetic and naturally occurring flavonoids on benzo[a]pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P-450 inducers

1991 • 54 citations

cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Purification, dependency on NADPH-P450 oxidoreductase, and reconstitution of catalytic properties without purification.

1995 • 34 citations

Inhibition of ethoxy- and pentoxy-resorufin dealkylases of rat liver by flavones and flavonols: structure-activity relationship

1989 • 24 citations

Modulation of Rat Hepatic Aryl Hydrocarbon Hydroxylase by Various Flavones and Polycyclic Aromatic Hydrocarbons

1985 • 14 citations

Kinetics of CO Binding to Cytochromes P450 in the Endoplasmic Reticulum

1994 • 14 citations

Interaction of Polycyclic Aromatic Hydrocarbons and Flavones with Cytochromes P450 in the Endoplasmic Reticulum: Effect on CO Binding Kinetics

1995 • 6 citations

Analysis of relaxation processes helps to define molecular states in biological systems

1993 • 4 citations