Activation of phenacetinO-deethylase activity byα-naphthoflavone in human liver microsomes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Drug Metabolism and Disposition

2014 • 2,466 citations

Cancer epidemiology biomarkers & prevention

1991 • 920 citations

Molecular Pharmacology

1971 • 853 citations

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

1995 • 601 citations

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

1997 • 380 citations

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

1996 • 358 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

1994 • 348 citations

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

1995 • 295 citations

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation ofin vitrometabolism using cDNA-expressed human P450s and human liver microsomes

1996 • 263 citations

Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

1979 • 242 citations

Clinical Importance of Hepatic Cytochrome P450 in Drug Metabolism

1995 • 236 citations

Oxidation of Aflatoxin B1 by Bacterial Recombinant Human Cytochrome P450 Enzymes

1995 • 208 citations

Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

1996 • 192 citations

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

1989 • 154 citations

Use of in vitro human metabolism studies in drug development

1994 • 142 citations

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.

1994 • 142 citations

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

1996 • 140 citations

PHARMACOKINETIC DRUG INTERACTIONS

1969 • 133 citations

Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions

1981 • 85 citations

Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole

1997 • 77 citations

EFFECTS OF LYOPHILIZATION AND STORAGE OF RAT LIVER MICROSOMES ON ACTIVITY OF ANILINE HYDROXYLASE, CONTENTS OF CYTOCHROME b5 AND CYTOCHROME P-450 AND ANILINE-INDUCED P-450 DIFFERENCE SPECTRUM

1974 • 72 citations

Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone

1997 • 67 citations

Inhibitory effects of antiarrhythmic drugs on phenacetin O‐deethylation catalysed by human CYP1A2

1998 • 62 citations

Biochemical pharmacology

1981 • 46 citations

Cited By (0)

Loading...