Oxidative Modulation of Cyclic AMP-Dependent Protein Kinase in Human Fibroblasts: Possible Role in Psoriasis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

1990 • 827 citations

Protein Phosphorylation

1975 • 762 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.

1990 • 382 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2.

1982 • 334 citations

Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase.

1977 • 328 citations

Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function

1986 • 290 citations

Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.

1990 • 281 citations

Transcriptional regulation of the prolactin gene by ergocryptine and cyclic AMP

1981 • 276 citations

Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches

1985 • 265 citations

The pathophysiology of psoriasis

1991 • 239 citations

Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes

1985 • 234 citations

Protection against oxidants in biological systems : the superoxide theory of oxygen toxicity

1989 • 230 citations

Psoriatic Fibroblasts Induce Hyperproliferation of Normal Keratinocytes in a Skin Equivalent Model in Vitro

1985 • 220 citations

Identification, characterization, and quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a photoaffinity ligand.

1977 • 188 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Cyclic AMP second messenger systems

1991 • 175 citations

THE ROLE OF CYCLIC AMP IN CELL PROLIFERATION: A CRITICAL ASSESSMENT OF THE EVIDENCE

1983 • 165 citations

Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases.

1984 • 153 citations

Biochemical mechanisms of liver injury

1970 • 144 citations

Psoriasis

1984 • 99 citations

Retinoids affect collagen synthesis through inhibition of ascorbate-induced lipid peroxidation in cultured human dermal fibroblasts

1990 • 93 citations

An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.

1993 • 88 citations

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate

1991 • 87 citations

Transcriptional regulation by cAMP

1991 • 83 citations

Inhibition of liver microsomal lipid peroxidation by 13-cis-retinoic acid

1990 • 78 citations

Regulation of manganese superoxide dismutase: IL-1 and TNF induction in pulmonary artery and microvascular endothelial cells

1992 • 74 citations

A High-Affinity Binding Protein for the Regulatory Subunit of cAMP-Dependent Protein Kinase II in the Centrosome of Human Cells

1993 • 73 citations

Biochemical Mechanisms of Liver Injury

1979 • 73 citations

Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1$beta; and TNF-$alpha;

1995 • 68 citations

Superoxide dismutase in psoriasis, squamous cell carcinoma and basal cell epithelioma: an immunohistochemical study

1991 • 68 citations

In situ expression of messenger RNA of interleukin-1 and interleukin-6 in psoriasis: interleukin-6 involved in formation of psoriatic lesions

1991 • 67 citations

Oxidation of cysteines activates cGMP-dependent protein kinase.

1991 • 64 citations

Susceptibility of protein kinase C to oxidative inactivation: Loss of both phosphotransferase activity and phorbol diester binding

1987 • 63 citations

Antioxidant Enzymes in Psoriatic Fibroblasts and Erythrocytes

1996 • 59 citations

Induction of vascular relaxation by hydroperoxides

1986 • 58 citations

Deficiency of cyclic AMP-dependent protein kinases in human psoriasis.

1986 • 49 citations

Effects of divalent cations on the regulation of insulin-sensitive glucose transport and cAMP phosphodiesterase in adipocytes. Insulin-like effects of divalent cations.

1984 • 43 citations

Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine RIIs.

1992 • 36 citations

Association of type II cAMP-dependent protein kinase with p34cdc2 protein kinase in human fibroblasts.

1991 • 36 citations

Implication of Protein Oxidation in Protein Turnover, Aging, and Oxygen Toxicity

1988 • 36 citations

Retinoids Inhibit the Oxidative Modification of Protein Kinase C Induced by Oxidant Tumor Promoters

1993 • 35 citations

Retinoid Treatment of Human Psoriatic Fibroblasts Induces an Increase in Cyclic AMP-Dependent Protein Kinase Activity

1987 • 34 citations

A cAMP BINDING ABNORMALITY IN PSORIASIS

1989 • 32 citations

Hydrogen peroxide mediates the oxidative inactivation of enzymes following the switch from anaerobic to aerobic metabolism in Klebsiella pneumoniae.

1990 • 26 citations

Generation of hydrogen peroxide by cerebral‐cortex synaptosomes

1989 • 23 citations

Rapid Effect of Treatment of Psoriatic Erythrocytes with the Synthetic Retinoid Acitretin to Increase 8-Azido Cyclic AMP Bindings to the RI Regulatory Subunit

1993 • 15 citations