Protein Kinase C and Protein Kinase A Inhibit Calcium-dependent but not Stress-dependent c-Jun N-terminal Kinase Activation in Rat Liver Epithelial Cells

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Calcium signalling and cell proliferation

1995 • 501 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

G protein‐coupled receptors and signaling pathways regulating growth responses ¹

1996 • 221 citations

The Related Adhesion Focal Tyrosine Kinase Is Tyrosine-phosphorylated after β1-Integrin Stimulation in B Cells and Binds to p130cas

1997 • 214 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells

1996 • 142 citations

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

1996 • 142 citations

Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells

1997 • 118 citations

Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.

1990 • 118 citations

The Seven-transmembrane-spanning Receptors for Endothelin and Thrombin Cause Proliferation of Airway Smooth Muscle Cells and Activation of the Extracellular Regulated Kinase and c-Jun NH2-terminal Kinase Groups of Mitogen-activated Protein Kinases

1996 • 111 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Regulation of cell proliferation and growth by angiotensin II

1994 • 100 citations

Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.

1992 • 94 citations

Calcium regulation of immediate-early response genes

1994 • 93 citations

An Intracellular Calcium Signal Activates p70 but Not p90 Ribosomal S6 Kinase in Liver Epithelial Cells

1997 • 79 citations

Angiotensin II Activates at Least Two Tyrosine Kinases in Rat Liver Epithelial Cells

1995 • 69 citations

Cyclic AMP Inhibition of Thrombin-induced Growth in Vascular Smooth Muscle Cells Correlates with Decreased JNK1 Activity and c-Jun Expression

1996 • 58 citations