A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

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Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

1998 • 1,103 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

1998 • 522 citations

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

1997 • 503 citations

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1998 • 496 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

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In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation?

1994 • 220 citations

The role of the Caspase family of cysteine proteases in apoptosis

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A versatile synthetic dimerizer for the regulation of protein–protein interactions

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Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

1998 • 185 citations

Resistance of cultured peripheral T cells towards activation‐induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death‐inducing signaling complex

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Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization

1996 • 149 citations

Transfer of the HSV-tk Gene into Donor Peripheral Blood Lymphocytes for In Vivo Modulation of Donor Anti-Tumor Immunity after Allogeneic Bone Marrow Transplantation. The San Raffaele Hospital, Milan, Italy

1995 • 147 citations

Portrait of an executioner: the molecular mechanism of Fas/APO-1-induced apoptosis

1997 • 100 citations

The Extracellular Signal-regulated Kinase Pathway Is Required for Activation-induced Cell Death of T Cells

1999 • 99 citations

Prevention of Graft-Versus-Host Disease in Mice Using a Suicide Gene Expressed in T Lymphocytes

1997 • 93 citations

Use of Donor T-Lymphocytes Expressing Herpes-Simplex Thymidine Kinase in Allogeneic Bone Marrow Transplantation: A Phase I–II Study. Laboratorie d'Histocompatibilité et Thérapeutique Immuno-Moléculaire, Besançon, France

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Creating conditional mutations in mammals

1996 • 57 citations

Retrovirally TransducedEscherichia coli gptGenes Combine Selectability with Chemosensitivity Capable of Mediating Tumor Eradication

1993 • 41 citations

Treatment of Cytomegalovirus Diseases

1997 • 27 citations

EXAMINATION OF THE SENSITIVITY OF T CELLS TO FAS LIGATION

1998 • 25 citations

SELECTIVE CD4+ T-CELL DEPLETION DOES NOT PREVENT GRAFT-VERSUS-HOST DISEASE1

1998 • 24 citations

Relationship between proliferation and susceptibility to CD95- and CD2-mediated apoptosis in stimulated primary T lymphocytes: T cells manifesting proliferative unresponsiveness are preferentially susceptible to CD95-mediated apoptosis.

1997 • 15 citations

Cell Surface Tagging and a Suicide Mechanism in a Single Chimeric Human Protein

1999 • 10 citations

Legacy of Three Mile Island

1989 • 5 citations