Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 975 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 856 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier

1999 • 365 citations

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1997 • 304 citations

Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models

1992 • 289 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

2001 • 266 citations

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms.

1980 • 259 citations

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

1996 • 250 citations

Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.

1981 • 250 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

2002 • 209 citations

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

1995 • 194 citations

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

1992 • 184 citations

Direct Binding of Occupied Urokinase Receptor (uPAR) to LDL Receptor-related Protein Is Required for Endocytosis of uPAR and Regulation of Cell Surface Urokinase Activity

2001 • 184 citations

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.

1989 • 182 citations

Serum levels of the iron binding protein p97 are elevated in Alzheimer′s disease

1996 • 171 citations

Receptor-associated Protein Is a Folding Chaperone for Low Density Lipoprotein Receptor-related Protein

1996 • 162 citations

The Second and Fourth Cluster of Class A Cysteine-rich Repeats of the Low Density Lipoprotein Receptor-related Protein Share Ligand-binding Properties

1999 • 155 citations

The Putative Tumor Suppressor LRP1B, a Novel Member of the Low Density Lipoprotein (LDL) Receptor Family, Exhibits Both Overlapping and Distinct Properties with the LDL Receptor-related Protein

2001 • 139 citations

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin

1996 • 139 citations

Plasmin-induced Migration of Endothelial Cells

2002 • 130 citations

Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.

1994 • 104 citations

Embryonic Fibroblasts That Are Genetically Deficient in Low Density Lipoprotein Receptor-related Protein Demonstrate Increased Activity of the Urokinase Receptor System and Accelerated Migration on Vitronectin

1997 • 93 citations

Human melanotransferrin (p97) has only one functional iron‐binding site

1992 • 92 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

Maspin Inhibits Cell Migration in the Absence of Protease Inhibitory Activity

2002 • 84 citations

Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells

1993 • 74 citations

Analysis of normal neoplastic human tissues for the tumor‐associated protein p97

1981 • 73 citations

Conversion of Glu-Plasminogen to Lys-Plasminogen Is Necessary for Optimal Stimulation of Plasminogen Activation on the Endothelial Cell Surface

2001 • 72 citations

Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells

1991 • 72 citations

The role of the membrane‐bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell

2000 • 69 citations

Low Density Lipoprotein (LDL) Receptor-related Protein 1B Impairs Urokinase Receptor Regeneration on the Cell Surface and Inhibits Cell Migration

2002 • 66 citations

No grip, no growth: the conceptual basis of excessive proteolysis in the treatment of cancer

2000 • 55 citations

The membrane‐bound transferrin homologue melanotransferrin: roles other than iron transport?

2000 • 53 citations

The human melanoma associated protein melanotransferrin promotes endothelial cell migration and angiogenesis in vivo

2002 • 53 citations

The role of the urokinase receptor in extracellular matrix degradation by ht29 human colon carcinoma cells

1993 • 49 citations

Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease

2003 • 30 citations