Evidence for a Type 1 diabetes‐specific mechanism for the insulin gene‐associated IDDM2 locus rather than a general influence on autoimmunity

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Monoclonal antibody to a plasma membrane antigen of neurons.

1979 • 965 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

A Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission

1999 • 643 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

Seven Regions of the Genome Show Evidence of Linkage to Type 1 Diabetes in a Consensus Analysis of 767 Multiplex Families

2001 • 264 citations

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

2002 • 260 citations

Evaluation of Single Nucleotide Polymorphism Typing with Invader on PCR Amplicons and Its Automation

2000 • 220 citations

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1997 • 189 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

The INS 5′ Variable Number of Tandem Repeats Is Associated with IGF2 Expression in Humans

1998 • 141 citations

High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus.

1997 • 136 citations

Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?

1999 • 128 citations

The insulin gene in diabetes

2002 • 98 citations

Divergence between Genetic Determinants ofIGF2Transcription Levels in Leukocytes and ofIDDM2-Encoded Susceptibility to Type 1 Diabetes¹

1998 • 40 citations

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.

1998 • 32 citations

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene

1996 • 29 citations

Divergence between Genetic Determinants of IGF2 Transcription Levels in Leukocytes and of IDDM2-Encoded Susceptibility to Type 1 Diabetes

1998 • 27 citations

Type 1 diabetes and latent pernicious anaemia

1992 • 16 citations