Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 • 523 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

An RNA polymerase II elongation factor encoded by the human ELL gene

1996 • 277 citations

The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

1998 • 238 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

THERAPY-RELATED MYELOID LEUKEMIA

1996 • 170 citations

Overexpression of Wild-Type Retinoic Acid Receptor  (RAR) Recapitulates Retinoic Acid-Sensitive Transformation of Primary Myeloid Progenitors by Acute Promyelocytic Leukemia RAR-Fusion Genes

1999 • 94 citations

Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients--updated published cases and 16 new observations.

1993 • 75 citations

Efficient retroviral gene transfer to purified long-term repopulating hematopoietic stem cells

1994 • 55 citations

Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays

1999 • 48 citations

Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.

1996 • 36 citations

Developmental analysis and subcellular localization of the murine homologue of ELL

1997 • 24 citations

Overexpression of the MEN/ELL Protein, an RNA Polymerase II Elongation Factor, Results in Transformation of Rat1 Cells with Dependence on the Lysine-rich Region

1998 • 15 citations