Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic proteinin vitro

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase

1997 • 368 citations

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation

1998 • 362 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants.

1995 • 271 citations

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

1998 • 266 citations

Role for Cathepsin F in Invariant Chain Processing and Major Histocompatibility Complex Class II Peptide Loading by Macrophages

2000 • 229 citations

Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

1999 • 227 citations

Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins

1989 • 211 citations

Proteolysis in MHC Class II Antigen Presentation

2000 • 181 citations

The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation

1999 • 179 citations

Endosomal proteolysis and MHC class II function

1998 • 168 citations

Control of Antigen Presentation by a Single Protease Cleavage Site

2000 • 150 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

Kinetics of the pH-induced inactivation of human cathepsin L

1993 • 140 citations

The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B

1989 • 128 citations

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.

1997 • 101 citations

Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures

2000 • 90 citations

MHC molecules protect T cell epitopes against proteolytic destruction.

1992 • 87 citations

A rapid method to separate endosomes from lysosomal contents using differential centrifugation and hypotonic lysis of lysosomes

1999 • 85 citations

The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D.

1979 • 82 citations

Antigen processing by endosomal proteases determines which sites of sperm‐whale myoglobin are eventually recognized by T cells

1991 • 74 citations

Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules

1994 • 62 citations

HLA‐DR‐restricted presentation of purified myelin basic protein is independent of intracellular processing

1997 • 49 citations

Surface hydrophobicity and intracellular degradation of proteins.

1996 • 34 citations

Monoclonal Antibodies Against Cathepsin L and Procathepsin L of Different Species

1997 • 29 citations