Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

HLA and Disease Associations

1985 • 893 citations

Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.

1987 • 849 citations

Predicting the Evolution of Human Influenza A

1999 • 524 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.

1995 • 310 citations

De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding

1993 • 270 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

In vivo competition between self peptides and foreign antigens in T-cell activation

1988 • 216 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

1994 • 127 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

Conformational energy studies on N‐methylated analogs of thyrotropin releasing hormone, enkephalin, and luteinizing hormone‐releasing hormone

1980 • 99 citations

Participation of cathepsin B in processing of antigen presentation to MHC class II

1993 • 87 citations

Identification of a Potent Heterocyclic Ligand To Somatostatin Receptor Subtype 5 by the Synthesis and Screening of β-Turn Mimetic Libraries

1999 • 81 citations

The use of peptide analogs with improved stability and MHC binding capacity to inhibit antigen presentation in vitro and in vivo.

1990 • 67 citations

Aureolic acid antibiotics: a simple method for 2-deoxy-.beta.-glycosidation

1990 • 64 citations

Residues defining Vβ specificity in staphylococcal enterotoxins

1995 • 63 citations

Failure to demonstrate long-lived MHC saturation both in vitro and in vivo. Implications for therapeutic potential of MHC-blocking peptides.

1994 • 59 citations

Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules

1999 • 58 citations

Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5

1996 • 25 citations

Binding affinity independent contribution of peptide length to the stability of peptide-HLA-DR complexes in live antigen presenting cells

1998 • 17 citations

Influence of CD26 and integrins on the antigen sensitivity of human memory T cells

1996 • 16 citations

Evidence supporting a role for cathepsin B in the generation of T cell antigenic epitopes of human growth hormone

1993 • 12 citations

SAR for MHC class II binding tetrapeptides: Correlation with potential binding site

1997 • 7 citations

Steps up the botanical spiral

1994 • 5 citations