Chronophin Mediates an ATP-Sensing Mechanism for Cofilin Dephosphorylation and Neuronal Cofilin-Actin Rod Formation

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

2006 • 1,058 citations

Actin Depolymerizing Factor (ADF/Cofilin) Enhances the Rate of Filament Turnover: Implication in Actin-based Motility

1997 • 1,028 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin

2002 • 670 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

The role of cerebral ischemia in Alzheimer’s disease

2000 • 521 citations

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo

2006 • 418 citations

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

2005 • 377 citations

Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function

2000 • 374 citations

Reactivation of Phosphorylated Actin Depolymerizing Factor and Identification of the Regulatory Site

1995 • 369 citations

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics

2004 • 321 citations

Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 Complex

2002 • 320 citations

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

2005 • 280 citations

Actin-ATP Hydrolysis Is a Major Energy Drain for Neurons

2003 • 275 citations

Cdc42 Regulates Cofilin during the Establishment of Neuronal Polarity

2007 • 251 citations

Stimulation of the weak ATPase activity of human Hsp90 by a client protein 1 1Edited by G. von Heijne

2002 • 243 citations

Mechanisms of Suppression of α-Synuclein Neurotoxicity by Geldanamycin in Drosophila

2004 • 200 citations

Increase in Neurite Outgrowth Mediated by Overexpression of Actin Depolymerizing Factor

2000 • 187 citations

N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex

2007 • 181 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin

2007 • 176 citations

Geldanamycin Induces Heat Shock Protein 70 and Protects against MPTP-induced Dopaminergic Neurotoxicity in Mice

2005 • 171 citations

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

2002 • 144 citations

β-Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β: A Feedforward Mechanism for Alzheimer's Disease

2005 • 128 citations

Isolated hippocampal neurons in cryopreserved long‐term cultures: Development of neuroarchitecture and sensitivity to NMDA

1988 • 124 citations

Formation of actin-ADF/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons

2006 • 123 citations

Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies

2007 • 106 citations

Ischemia activates actin depolymerizing factor: role in proximal tubule microvillar actin alterations

1999 • 79 citations

Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses

2005 • 69 citations

Cofilin mediates ATP depletion-induced endothelial cell actin alterations

2006 • 46 citations