β-Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β: A Feedforward Mechanism for Alzheimer's Disease

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1999 • 1,787 citations

Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

2005 • 1,772 citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

2004 • 1,637 citations

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

2002 • 1,405 citations

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 • 1,313 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

2005 • 1,147 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 • 1,058 citations

Amyloid β-Protein Fibrillogenesis

1999 • 1,041 citations

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

2003 • 1,027 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis

2003 • 941 citations

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

2004 • 928 citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

1999 • 797 citations

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

2005 • 659 citations

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

2003 • 547 citations

Self-Assembly of Aβ_1-42into Globular Neurotoxins

2003 • 510 citations

Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

2002 • 491 citations

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

2004 • 434 citations

Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function

2000 • 374 citations

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

2004 • 363 citations

An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture. I. Cells which develop without intercellular contacts

1984 • 358 citations

Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

2003 • 351 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

2000 • 286 citations

Actin-ATP Hydrolysis Is a Major Energy Drain for Neurons

2003 • 275 citations

ADF/cofilin and actin dynamics in disease

2002 • 275 citations

CSF Total tau, Aβ42 and Phosphorylated tau Protein as Biomarkers for Alzheimer's Disease

2001 • 266 citations

Role of the β‐amyloid protein in Alzheimer's disease

1995 • 258 citations

Actin depolymerizing factor and cofilin phosphorylation dynamics: Response to signals that regulate neurite extension

1998 • 253 citations

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.

1995 • 212 citations

Selective neuronal degeneration induced by soluble oligomeric amyloid beta‐protein

2002 • 205 citations

Increase in Neurite Outgrowth Mediated by Overexpression of Actin Depolymerizing Factor

2000 • 187 citations

Hirano bodies and related neuronal inclusions

1994 • 185 citations

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

2002 • 149 citations

Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

2002 • 144 citations

Trafficking of cell-surface amyloid β-protein precursor: II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization

1996 • 132 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

Isolated hippocampal neurons in cryopreserved long‐term cultures: Development of neuroarchitecture and sensitivity to NMDA

1988 • 124 citations

Down syndrome and beta-amyloid deposition

2004 • 123 citations

Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea

1996 • 116 citations

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein.

1998 • 115 citations

Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms.

2003 • 104 citations

Culturing Hippocampal and Cortical Neurons

2003 • 103 citations

Amyloid beta amyloidosis in Alzheimerʼs disease

1995 • 102 citations

A Cofilin-Like Protein Is Involved in the Regulation of Actin Assembly in Developing Skeletal Muscle1

1989 • 94 citations

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

2003 • 93 citations

Amyloid ? protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

1998 • 86 citations

Screening for the β-amyloid precursor protein mutation (APP717: Val → Ile) in extended pedigrees with early onset Alzheimer's disease

1991 • 80 citations

Amyloid β-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-d-aspartate (NMDA) versus non-NMDA receptor/channel activation

2004 • 75 citations

Two actin binding proteins, actin depolymerizing factor and cofilin, are associated with Hirano bodies

1995 • 75 citations

Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751)

1999 • 42 citations

Oxidative stress after acute and chronic application of β-amyloid fragment 25–35 in cortical cultures

1996 • 37 citations