Glycine-Independent NMDA Receptor Desensitization: Localization of Structural Determinants

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region

1991 • 688 citations

A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors

1994 • 607 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit

1996 • 532 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies

1997 • 490 citations

The impact of receptor desensitization on fast synaptic transmission

1996 • 478 citations

Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

1997 • 470 citations

Alternatively spliced isoforms of the NMDARI receptor subunit

1995 • 450 citations

NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins

1997 • 439 citations

Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

1994 • 424 citations

Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine

1989 • 408 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

NMDA channel behavior depends on agonist affinity

1992 • 401 citations

Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

1993 • 394 citations

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

1994 • 381 citations

AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate

1996 • 343 citations

β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase

1996 • 280 citations

NMDA receptor channels: Subunit-specific potentiation by reducing agents

1994 • 263 citations

Excitatory amino acids

1998 • 257 citations

Activation and desensitization of N‐methyl‐D‐aspartate receptors in nucleated outside‐out patches from mouse neurones.

1992 • 240 citations

Periplasmic binding protein structure and function

1989 • 229 citations

Structure of the NMDA Receptor Channel M2 Segment Inferred from the Accessibility of Substituted Cysteines

1996 • 228 citations

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

1996 • 225 citations

A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.

1990 • 216 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Excitatory amino acids and synaptic transmission

1995 • 185 citations

Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific.

1996 • 172 citations

N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents.

1994 • 166 citations

The Crystal Structure of Glutamine-binding Protein fromEscherichia coli

1996 • 162 citations

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

1993 • 130 citations

Identification of Amino Acid Residues that Control Functional Behavior in GluR5 and GluR6 Kainate Receptors

1997 • 118 citations

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

1990 • 117 citations

Promoter-cDNA-directed heterologous protein expression in Xenopus laevis oocytes.

1992 • 116 citations

AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity

1995 • 111 citations

Calcium‐mediated modulation of N‐methyl‐D‐aspartate (NMDA) responses in cultured rat hippocampal neurones.

1993 • 111 citations

Spermine regulates N-methyl-d-aspartate receptor desensitization

1992 • 110 citations

Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine.

1995 • 110 citations

Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons

1990 • 109 citations

Regulation of glycine-insensitive desensitization of the NMDA receptor in outside-out patches

1994 • 99 citations

A Venus Flytrap Mechanism for Activation and Desensitization of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptors

1996 • 92 citations

Calcium‐dependent inactivation of heteromeric NMDA receptor‐channels expressed in human embryonic kidney cells.

1995 • 77 citations

Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons.

1995 • 73 citations

Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons

1990 • 65 citations

Characterization of Glutamate Binding Sites in Receptors Assembled from Transfected NMDA Receptor Subunits

1996 • 52 citations

Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus.

1991 • 32 citations

Spatial Learning and Memory: The Beginning of a Dream

1996 • 32 citations

Role of the Putative Transmembrane Segment M3 in Gating of Neuronal Nicotinic Receptors

1997 • 26 citations

N‐Methyl D‐aspartate Receptors

2008 • 9 citations

A fast and simple method to introduce multiple distant point mutations

1997 • 9 citations

Eukaryotic gene transcription edited by Stephen Goodbourn IRL Press, 1996. £29.50 pbk (312 pages) ISBN 0 19 963486 6

1997 • 4 citations