Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis

Two-Photon Laser Scanning Fluorescence Microscopy

1990 • 9,129 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Measurement of co‐localization of objects in dual‐colour confocal images

1993 • 1,979 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

Applying watershed algorithms to the segmentation of clustered nuclei

1998 • 432 citations

Superresolution Three-Dimensional Images of Fluorescence in Cells with Minimal Light Exposure

1995 • 345 citations

Intracellular pH and the control of multidrug resistance.

1994 • 273 citations

Defective pH Regulation of Acidic Compartments in Human Breast Cancer Cells (MCF-7) Is Normalized in Adriamycin-Resistant Cells (MCF-7adr)

1996 • 258 citations

A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells

1994 • 249 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry

1995 • 151 citations

Comparative Study on Reversal Efficacy of SDZ PSC 833, Cyclosporin a and Verapamil on Multidrug Resistance in vitro and in vivo

1995 • 107 citations

Effect of verapamil and other agents on the distribution of anthracyclines and on reversal of drug resistance.

1987 • 96 citations

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

1992 • 94 citations

Artifacts in computational optical-sectioning microscopy

1994 • 90 citations

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients

1996 • 82 citations

P‐glycoprotein expression in the Golgi apparatus of multidrug‐resistant cells

1994 • 81 citations

Functional intracellular P‐glycoprotein

1998 • 65 citations

The role of specimen‐induced spherical aberration in confocal microscopy

1997 • 62 citations

Functional intracellular P-glycoprotein

1998 • 62 citations

Sequestration of doxorubicin in vesicles in a multidrug-resistant cell line (LZ-100)

1994 • 54 citations

Optimization of immunofluorescence methods by quantitative image analysis.

1996 • 51 citations

Chromatic shift in multicolour confocal microscopy

1997 • 51 citations

Evidence for cytoplasmic P-glycoprotein location associated with increased multidrug resistance and resistance to chemosensitizers.

1996 • 43 citations

Interest of image processing in cell biology and immunology

1997 • 35 citations

Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies

1994 • 33 citations

Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line

1995 • 32 citations

Heterogeneous photobleaching in confocal microscopy caused by differences in refractive index and excitation mode

1998 • 29 citations

Cytometric study of intracellular P-gp expression and reversal of drug resistance

1998 • 28 citations

Quantitation of cell-matrix adhesion using confocal image analysis of focal contact associated proteins and interference reflection microscopy

1997 • 21 citations

Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.

1998 • 19 citations

Influence of SDZ‐PSC833 on daunorubicin intracellular accumulation in bone marrow specimens from patients with acute myeloid leukaemia

1998 • 16 citations

Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in p‐glycoprotein‐expressing MCF7 human breast adenocarcinoma cells

1995 • 8 citations

Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators

1996 • 5 citations

<title>Fluorescence microscopy image deconvolution: application to anthracycline distribution in breast cancer cells</title>

1997 • 1 citations