Comparative Study on Reversal Efficacy of SDZ PSC 833, Cyclosporin a and Verapamil on Multidrug Resistance in vitro and in vivo

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.

1986 • 231 citations

MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

1988 • 230 citations

Function and Regulation of the Human Multidrug Resistance Gene

1992 • 186 citations

Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma

1986 • 147 citations

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

1991 • 126 citations

Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.

1983 • 119 citations

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics.

1983 • 116 citations

SDZ PSC 833, a non-immunosuppressive cyclosporin analog, is a very potent multidrug-resistance modifier

1991 • 87 citations

Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicity

1992 • 80 citations

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver

1992 • 70 citations

Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing themdr1 phenotype

1992 • 66 citations

Reversal of multidrug resistance by an immunosuppressive agent FK-506

1992 • 63 citations

In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.

1989 • 54 citations

MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells.

1988 • 50 citations

A possible role for cyclosporins in cancer chemotherapy.

1988 • 47 citations

Comparison of cyclosporin A and SDZ PSC833 as multidrug-resistance modulators in a daunorubicin-resistant Ehrlich ascites tumor

1992 • 42 citations

Characteristics of vincristine resistance in vincristine resistant human myelogenous leukemia K562.

1986 • 21 citations

A fluorine-containing anthracycline (ME2303) as a new antitumor agent against murine and human tumors and their multidrug-resistant sublines.

1989 • 19 citations

In vivo evidence of complete circumvention of vincristine resistance by a new triazinoaminopiperidine derivative S 9788 in P388/VCR leukemia model

1992 • 17 citations

Cited By (0)

No citing papers found in database