Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae

1991 • 465 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells

1975 • 300 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

Role of Ca2+-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2+-ATPase inhibitor, thapsigargin

1990 • 276 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Routing of internalized ricin and ricin conjugates to the Golgi complex.

1986 • 231 citations

Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores.

1990 • 226 citations

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

1990 • 185 citations

Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled DNA synthesis in normal human lymphocytes

1982 • 181 citations

Specific binding of phorbol ester tumor promoters to mouse skin

1980 • 152 citations

The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine

1987 • 147 citations

3‐Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism

1988 • 131 citations

Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.

1983 • 128 citations

Internucleosomal DNA cleavage precedes diphtheria toxin-induced cytolysis

1989 • 125 citations

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

1990 • 125 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.

1988 • 113 citations

Phorbol esters inhibit apoptosis in IL-2-dependent T lymphocytes

1989 • 95 citations

Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL‐60 cells

1990 • 89 citations

Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.

1985 • 83 citations

DNA Fragmentation in Targets of CTL: An Example of Programmed Cell Death in the Immune System

1985 • 81 citations

Receptor-mediated endocytosis of a ricin-colloidal gold conjugate in vero cells

1985 • 74 citations

Second Cytotoxic Pathway of Diphtheria Toxin Suggested by Nuclease Activity

1989 • 66 citations

Internalization efficiency of the transferrin receptor

1992 • 55 citations

Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin.

1986 • 49 citations

Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate

1990 • 48 citations

Distinct pathways of CD4 and CD8 cells induce rapid target DNA fragmentation.

1991 • 39 citations

Mechanism of human lymphotoxin and tumor necrosis factor induced destruction of cells in vitro: Phospholipase activation and deacylation of specific‐membrane phospholipids

1990 • 37 citations

Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes

1987 • 30 citations

Regulation of the breakdown rates of biotin-containing proteins in Swiss 3T3-L1 cells

1988 • 28 citations

Does Diphtheria Toxin Have Nuclease Activity?

1990 • 19 citations

In Reply: Does Diphtheria Toxin Have Nuclease Activity?

1990 • 19 citations

Bacterial protein toxins acting on intracellular targets.

1991 • 17 citations

Comparison of the intoxication pathways of tumor necrosis factor and diphtheria toxin

1990 • 15 citations

Regulation of protein breakdown by epidermal growth factor in A431 cells

1985 • 13 citations

Effects of inhibitors on aldolase breakdown after its microinjection into HeLa cells

1989 • 4 citations

Does Diphtheria Toxin Have Nuclease Activity?

1990 • 3 citations