DNA Fragmentation in Targets of CTL: An Example of Programmed Cell Death in the Immune System

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease

1973 • 1,176 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Cell death in biology and pathology

1981 • 290 citations

The sensitivity of lymphocytes to ionising radiation

1952 • 289 citations

Studies on colony formation in vitro by mouse bone marrow cells. II. Action of colony stimulating factor

1970 • 233 citations

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

1983 • 229 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

Regeneration of T-cell helper function in zinc-deficient adult mice

1978 • 188 citations

The differentiation of T lymphocytes

1974 • 185 citations

THYMUS-MARROW IMMUNOCOMPETENCE

1971 • 170 citations

DNA in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments

1976 • 145 citations

Mammalian chromatin substructure studies with the calcium–magnesium endonuclease and two-dimensional polyacrylamide-gel electrophoresis

1974 • 142 citations

Cell death in biology and pathology

1982 • 131 citations

The calcium dependent endonuclease activity of isolated nuclear preparations. Relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations

1973 • 127 citations

Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

1980 • 119 citations

Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy.

1980 • 98 citations

Direct enzyme transfer from lymphocytes is specific

1983 • 87 citations

Radiosensitivity of T and B lymphocytes. III. Effect of radiation on immunoglobulin production by B cells.

1975 • 80 citations

Radiosensitivity of T and B lymphocytes. IV. Effect of whole body irradiation upon various lymphoid tissues and numbers of recirculating lymphocytes.

1977 • 68 citations

Effect of glucocorticoid hormones in vitro on the structural integrity of nuclei in corticosteroid-sensitive and -resistant lines of lymphosarcoma P1798.

1978 • 48 citations

Radiosensitivity of T and B Lymphocytes

1977 • 47 citations

Purification of Erythropoietin-Responsive Cells by Immune Hemolysis

1972 • 44 citations

Thymic control of proliferation of T cell precursors in bone marrow.

1979 • 17 citations