The Link between Thyroid Function and Depression

Neuroimaging studies of mood disorders

2000 • 1,303 citations

SALMONELLAS IN MEAT.

1964 • 1,158 citations

Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment

2003 • 1,115 citations

Modulation of Cortical-Limbic Pathways in Major Depression

2004 • 1,042 citations

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Evaluation and Treatment of Hyperthyroidism and Hypothyroidism

2002 • 662 citations

Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy

2001 • 576 citations

EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION*1

1972 • 558 citations

Relationships between Circulating and Intracellular Thyroid Hormones: Physiological and Clinical Implications*

1981 • 549 citations

Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review

1982 • 504 citations

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

2008 • 499 citations

Triiodothyronine Augmentation in the Treatment of Refractory Depression

1996 • 483 citations

Psychological well‐being in patients on ‘adequate’ doses of <scp>l</scp>‐thyroxine: results of a large, controlled community‐based questionnaire study

2002 • 474 citations

Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone

1969 • 392 citations

The Thyroid‐Brain Interaction in Thyroid Disorders and Mood Disorders

2008 • 390 citations

IMPROVEMENT IN MENTAL DEPRESSION WITH DECREASED THYROTROPIN RESPONSE AFTER ADMINISTRATION OF THYROTROPIN-RELEASING HORMONE

1972 • 374 citations

Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

2001 • 373 citations

BLOOD AND BONES.

1964 • 363 citations

Mental Changes Accompanying Thyroid Gland Dysfunction

1969 • 349 citations

A Hypothesis of Thyroid-Catecholamine-Receptor Interaction

1981 • 337 citations

Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients

2009 • 312 citations

Brain Blood Flow Changes in Depressed Patients Treated With Interpersonal Psychotherapy or Venlafaxine Hydrochloride

2001 • 309 citations

Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture

1975 • 300 citations

The Comparative Antidepressant Value of L-Tryptophan and Imipramine With and Without Attempted Potentiation by Liothyronine

1972 • 248 citations

Does Thyroid Supplementation Accelerate Tricyclic Antidepressant Response? A Review and Meta-Analysis of the Literature

2001 • 248 citations

Rapid Cycling Bipolar Affective Disorder

1990 • 247 citations

Association between postpartum thyroid dysfunction and thyroid antibodies and depression.

1992 • 242 citations

Thyroid hormone transport in and out of cells

2008 • 234 citations

The Thyroid Axis and Depression

1998 • 218 citations

Influence of Glucocorticoids on TRF-Induced TSH Response in Man

1973 • 204 citations

Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects

1988 • 181 citations

Potentiation of Amitriptyline by Thyroid Hormone

1972 • 168 citations

Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum

2001 • 166 citations

Autoimmune thyroiditis and a rapidly progressive dementia: Global hypoperfusion on SPECT scanning suggests a possible mechanism

1997 • 162 citations

A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants

1990 • 156 citations

Antithyroid antibodies in depressed patients

1985 • 148 citations

Cerebral Blood Flow and Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study

2001 • 145 citations

The thyrotropin response to thyrotropin-releasing hormone in endogenous depression

1981 • 141 citations

Thyroid-Hormone Enhancement of Imipramine in Nonretarded Depressions

1970 • 138 citations

Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression

1979 • 136 citations

Brain Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study before and after Thyroid Hormone Replacement Therapy

2009 • 132 citations

Concentrations of Thyroxine and 3,5,3′-Triiodothyronine at 34 Different Sites in Euthyroid Rats as Determined by an Isotopic Equilibrium Technique

1985 • 130 citations

Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

2001 • 123 citations

U.S. experience with valproate in manic depressive illness: a multicenter trial.

1989 • 122 citations

Elevation of immunoreactive CSF TRH in depressed patients

1988 • 119 citations

A psychiatric and neuropsychological study of patients with untreated Graves' disease

1988 • 116 citations

Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain.

1992 • 114 citations

Low Levels of Transthyretin in the CSF of Depressed Patients

1999 • 108 citations

“Symptomless” autoimmune thyroiditis in depression

1982 • 107 citations

Altered serum levels of thyroxine, triiodothyronines and diiodothyronines in endogenous depression

1981 • 103 citations

Transient post-partum thyroid dysfunction and postnatal depression

1989 • 94 citations

The relationship of anxiety and depression to symptoms of hyperthyroidism using operational criteria

1986 • 93 citations

Polymorphisms in the brain‐specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients

2008 • 93 citations

Low Cerebrospinal Fluid Transthyretin Levels in Depression: Correlations with Suicidal Ideation and Low Serotonin Function

2006 • 89 citations

Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study (CaPS) and a meta‐analysis

2008 • 87 citations

The presence of antithyroid antibodies in patients with affective and nonaffective psychiatric disorders

1990 • 87 citations

Randomised trial of thyroxine to prevent postnatal depression in thyroid-antibody-positive women

2002 • 84 citations

Thyroid function in clinical subtypes of major depression: an exploratory study

2004 • 77 citations

Thyrotropin-Releasing Hormone Receptor 1-Deficient Mice Display Increased Depression and Anxiety-Like Behavior

2007 • 76 citations

The Effect of Tricyclic Antidepressants on Basal Thyroid Hormone Levels in Depressed Patients

1990 • 76 citations

Hormones of the Hypothalamic-pituitary-thyroid Axis: A Psychoneuroendocrine Perspective

1986 • 73 citations

Supraphysiological Doses of L-Thyroxine in the Maintenance Treatment of Prophylaxis-Resistant Affective Disorders

2002 • 70 citations

Thyroid axis activity and serotonin function in major depressive episode

1999 • 66 citations

Regional cerebral blood flow in patients with mild hypothyroidism.

2004 • 64 citations

Serum thyrotropin in hospitalized psychiatric patients: Evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay

1990 • 63 citations

The International encyclopedia of depression

2009 • 61 citations

Thyroxine and the treatment of affective disorders: an overview of the results of basic and clinical research

2000 • 60 citations

The influence of desipramine on thyroid hormone metabolism in rat brain.

1994 • 58 citations

CSF transthyretin in patients with depression

1993 • 58 citations

Subchronic administration of fluoxetine to rats affects triidothyronine production and deiodination in regions of the cortex and in the limbic forebrain

1994 • 56 citations

A relação entre a função tireoidiana e a depressão: uma revisão

2004 • 55 citations

Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine

2008 • 51 citations

Prevalence of depression in patients affected by subclinical hypothyroidism.

2010 • 50 citations

Low Plasma Thyroid Indices of Depressed Patients are Attenuated by Antidepressant Drugs and Influence Treatment Outcome

1996 • 50 citations

Effects of various antidepressants on serum thyroid hormone levels in patients with major depressive disorder

2008 • 46 citations

Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain

1992 • 46 citations

Increased depressive behaviour in mice harboring the mutant thyroid hormone receptor alpha 1

2010 • 45 citations

Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy —analysis by Tc-99m-HMPAO and SPM96—

2004 • 43 citations

High reverse T3 levels in manic and unipolar depressed women

1982 • 42 citations

Low T3 syndrome in psychiatric depression

2006 • 42 citations

Simultaneous initiation (coinitiation) of pharmacotherapy with triiodothyronine and a selective serotonin reuptake inhibitor for major depressive disorder: a quantitative synthesis of double-blind studies

2008 • 42 citations

Increased production of thyroxine and inappropriately elevated serum thyrotropin in levels in endogenous depression

1990 • 41 citations

Hypothalamic–pituitary–thyroid-axis function in treatment resistant depression

1997 • 41 citations

Brain SPECT study of common ground between hypothyroidism and depression

2006 • 40 citations

Psychoneuroendocrinology: The Scientific Basis of Clinical Practice

2003 • 38 citations

Thyroid hormone transporters in the brain

2008 • 38 citations

Thyrotropin-Releasing Hormone (TRH), the Thyroid Axis, and Affective Disorder

1989 • 37 citations

Thyrotropin-Releasing Hormone (TRH), the Thyroid Axis, and Affective Disorder

1989 • 37 citations

CSF triiodothyronine (rT3) levels in patients with affective disorders.

1983 • 36 citations

Antithyroid antibodies in major depression

1987 • 35 citations

Depression in thyrotoxicosis

1975 • 32 citations

Reversible Cerebral Hypoperfusion Observed With Tc-99m HMPAO SPECT in Reversible Dementia Caused by Hypothyroidism

1999 • 31 citations

The movement of thyroid hormones in the central nervous system.

1992 • 31 citations

Cerebral Blood Flow and Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study

2001 • 30 citations

Influence of thyroid hormones on morning and evening TSH response to TRH in major depression

1994 • 26 citations

Dose-Response Studies With Protirelin

1994 • 25 citations

Sensitive assay of thyroid stimulating hormone in depressed patients

1995 • 23 citations

Basal Thyrotropin and Major Depression: Relation to Clinical Variables and Treatment Outcome

2008 • 22 citations

Antidepressants inhibit the glucocorticoid stimulation of thyrotropin releasing hormone expression in cultured hypothalamic neurons.

1998 • 21 citations

Thyrotropin-Releasing Hormone (TRH)

2003 • 14 citations

[Problems of long-term therapy with anticoagulants].

1992 • 13 citations

Catecholamines and Depression: A Physiological Theory of Depression

1974 • 8 citations