Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1988 • 822 citations

New anticonvulsant drugs

1987 • 314 citations

Pharmacokinetics and metabolism of gabapentin in rat, dog and man.

1986 • 268 citations

Gabapentin in partial epilepsy

1990 • 205 citations

Progression and Generalization of Seizure Discharge: Anatomical and Neurochemical Substrates

1988 • 203 citations

Valproate induced changes in GABA metabolism at the subcellular level

1981 • 125 citations

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: Are there common or different sites of action?

1983 • 97 citations

Valproate enhances GABA turnover in the substantia nigra

1989 • 80 citations

Gabapentin decreases monoamine release without affecting acetylcholine release in the brain.

1985 • 67 citations

Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment.

1989 • 65 citations

The effects of sodium valproate on γ-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice

1982 • 64 citations

Use of Inhibitors of γ‐Aminobutyric Acid (GABA) Transaminase for the Estimation of GABA Turnover in Various Brain Regions of Rats: A Reevaluation of Aminooxyacetic Acid

1989 • 59 citations

Anticonvulsant and biochemical effects of inhibitors of gaba aminotransferase and valproic acid during subchronic treatment in mice

1982 • 49 citations

Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons.

1986 • 48 citations

Development of a synaptosomal model to determine drug-induced in vivo changes in GABA-levels of nerve endings in 11 brain regions of the rat

1984 • 43 citations

Deleted Work

1955 • 0 citations