Autocrine Human Growth Hormone (hGH) Regulation of Human Mammary Carcinoma Cell Gene Expression

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study¹

1998 • 824 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

2000 • 760 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

1993 • 551 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response

1999 • 445 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

2000 • 244 citations

Characterization of the stress-inducing effects of homocysteine

1998 • 231 citations

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

1995 • 230 citations

Amino Acid Limitation Induces Expression of CHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1997 • 203 citations

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

1996 • 202 citations

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

1993 • 199 citations

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

1994 • 197 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

2000 • 187 citations

ski can cause selective growth of skeletal muscle in transgenic mice.

1990 • 174 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

Isolation of human cDNA clones ofskiand the ski-related gene,sno

1989 • 169 citations

Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5

1995 • 169 citations

NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type

1999 • 159 citations

The unfolded-protein-response pathway in yeast

1994 • 154 citations

Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA

1992 • 153 citations

Wnt-1 Induces Growth, Cytosolic β-Catenin, and Tcf/Lef Transcriptional Activation in Rat-1 Fibroblasts

1998 • 153 citations

Cellular expression of growth hormone and prolactin receptors in human breast disorders

1998 • 147 citations

GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.

1996 • 144 citations

The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction.

1994 • 141 citations

Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells

1994 • 140 citations

CHOP Enhancement of Gene Transcription by Interactions with Jun/Fos AP-1 Complex Proteins

1999 • 138 citations

Isolation, characterization and chromosomal localization of the human GADD153 gene

1992 • 130 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Growth hormone mRNA in mammary gland tumors of dogs and cats.

1995 • 124 citations

Expression and binding properties of two isoforms of the human growth hormone receptor

1993 • 114 citations

The role of prolactin and growth hormone in breast cancer

2000 • 110 citations

Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.

1993 • 110 citations

Autocrine Stimulation of Human Mammary Carcinoma Cell Proliferation by Human Growth Hormone

1999 • 107 citations

Comparison of methods based on annexin-V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells.

1999 • 101 citations

The Effects of Autocrine Human Growth Hormone (hGH) on Human Mammary Carcinoma Cell Behavior Are Mediated via the hGH Receptor¹

2001 • 92 citations

Expression of the gene encoding growth hormone in the human mammary gland.

1995 • 87 citations

YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex.

1994 • 84 citations

Janus Kinase 2-dependent Activation of p38 Mitogen-activated Protein Kinase by Growth Hormone

2000 • 83 citations

Growth Hormone and Insulin-Like Growth Factor I Induce Bone Morphogenetic Proteins 2 and 4: A Mediator Role in Bone and Tooth Formation?¹

1998 • 82 citations

APC truncation and increased β-catenin levels in a human breast cancer cell line

2000 • 79 citations

Human Translocation Liposarcoma-CCAAT/Enhancer Binding Protein (C/EBP) Homologous Protein (TLS-CHOP) Oncoprotein Prevents Adipocyte Differentiation by Directly Interfering with C/EBPβ Function

1998 • 75 citations

MOLECULAR EVIDENCE FOR THE PRESENCE OF GROWTH HORMONE RECEPTORS IN THE BOVINE MAMMARY GLAND

1990 • 74 citations

Glutamine Deprivation Induces the Expression ofGADD45 and GADD153 Primarily by mRNA Stabilization

1999 • 73 citations

The mechanism of effect of growth hormone on preadipocyte and adipocyte function

2000 • 72 citations

Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.

1992 • 69 citations

Role of growth hormone and insulin-like growth factor-I in mammary development.

1993 • 66 citations

Localization of growth hormone receptor messenger RNA in human tissues

1995 • 61 citations

Characterization of chicken c-ski oncogene products expressed by retrovirus vectors.

1990 • 60 citations

Wnt Signaling Stabilizes the Dual‐Function Protein β‐Catenin in Diverse Cell Types^a

1998 • 55 citations

Transcriptional Repression by v-Ski and c-Ski Mediated by a Specific DNA Binding Site

1998 • 54 citations

Novel Interaction between the Transcription Factor CHOP (GADD153) and the Ribosomal Protein FTE/S3a Modulates Erythropoiesis

2000 • 54 citations

Growth Hormone-Induced Reorganization of the Actin Cytoskeleton Is Not Required for STAT5 (Signal Transducer and Activator of Transcription-5)-Mediated Transcription*

1997 • 53 citations

Identification and characterization of growth hormone receptor mRNA in the mammary gland

1991 • 48 citations

Potentiation of heat stress-induced hsp70 expression in vivo by aspirin

1997 • 48 citations

Growth hormone prevents human monocytic cells from Fas-mediated apoptosis by up-regulating Bcl-2 expression

1999 • 48 citations

Growth Hormone Promotion of Tubulin Polymerization Stabilizes the Microtubule Network and Protects Against Colchicine-Induced Apoptosis**Supported by monies from the National Science and Technology Board of Singapore (to P.E.L.).

1998 • 45 citations

Expression and distribution of messenger ribonucleic acids for growth hormone (GH) receptor and GH-binding protein in mice during pregnancy.

1995 • 44 citations

Activation of a muscle-specific enhancer by the Ski proto-oncogene

1995 • 41 citations

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

1999 • 39 citations

In vitro effects of growth hormone (GH) and insulin-like growth factor I and II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes

1998 • 38 citations

Polyproteins containing a domain encoded by the V-SKI oncogene are located in the nuclei of SKV-transformed cells

1986 • 36 citations

Growth hormone receptors expression in the proliferating rat mammary gland.

1990 • 32 citations

Yin-yang 1 and Glucocorticoid Receptor Participate in the Stat5-mediated Growth Hormone Response of the Serine Protease Inhibitor 2.1 Gene

2000 • 31 citations

Autocrine Human Growth Hormone Enhancement of Human Mammary Carcinoma Cell Spreading Is Jak2 Dependent*

2000 • 31 citations

Introduction of gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis.

1999 • 28 citations

Molecular Cloning and Analysis of a Group of Genes Differentially Expressed in Cells Which Overexpress the Hoxa-1 Homeobox Gene

2000 • 25 citations

Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski.

1999 • 21 citations

Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines.

2000 • 20 citations

Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1

1999 • 20 citations

Comparison of methods based on annexin‐V binding, DNA content or TUNEL for evaluating cell death in HL‐60 and adherent MCF‐7 cells

1999 • 18 citations

Expression of the gadd153 gene in normal and tumor breast tissues by a sensitive RT-PCR method.

1999 • 10 citations

Amplification of the Golgi complex in MDCK cells secreting human growth hormone

1993 • 8 citations