Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Dendritic organization in the neurons of the visual and motor cortices of the cat.

1953 • 2,180 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Pathways to neuronal injury and apoptosis in HIV-associated dementia

2001 • 1,190 citations

Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

1998 • 709 citations

Mixed-lineage kinase control of JNK and p38 MAPK pathways

2002 • 556 citations

Pattern Discrimination and the Visual Cortex

1953 • 545 citations

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis

1999 • 513 citations

Dopamine transporters and neuronal injury

1999 • 376 citations

Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

2003 • 289 citations

Cell death in HIV dementia

2005 • 285 citations

Synaptic transmission in the striatum: from plasticity to neurodegeneration

2000 • 280 citations

Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: Protection by memantine

2000 • 259 citations

Distribution of Brain HIV Load in AIDS

1998 • 252 citations

Chapter II The basal ganglia

1996 • 240 citations

Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia

2000 • 210 citations

Synergistic increases in intracellular Ca²⁺, and the release of MCP‐1, RANTES, and IL‐6 by astrocytes treated with opiates and HIV‐1 Tat

2005 • 209 citations

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells

1997 • 200 citations

Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

2000 • 190 citations

Cross-talk between JNK/SAPK and ERK/MAPK Pathways

2003 • 182 citations

Induction of the Chemokines Interleukin-8 and IP-10 by Human Immunodeficiency Virus Type 1 Tat in Astrocytes

2000 • 170 citations

“Apoptotic” biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders

1999 • 168 citations

The selective vulnerability of striatopallidal neurons

1999 • 168 citations

Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

2001 • 164 citations

Regulation of c‐Jun N‐terminal kinase, p38 kinase and AP‐1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

2003 • 150 citations

Brain Viral Burden in HIV Infection

1994 • 138 citations

Human Immunodeficiency Virus Type 1 (HIV-1) Tat Induces Nitric-oxide Synthase in Human Astroglia

2002 • 136 citations

Parkinsonism with HIV infection

1998 • 135 citations

Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

2001 • 127 citations

HIV Dementia and the Basal Ganglia

1997 • 125 citations

Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G

2004 • 117 citations

Pathobiology of Human Immunodeficiency Virus Dementia

1999 • 117 citations

HIV-Tat Protein Activates c-Jun N-Terminal Kinase and Activator Protein-1

1998 • 116 citations

Human immunodeficiency virus type 1 and its coat protein gp 120 induce apoptosis and activate JNK and ERK mitogen‐activated protein kinases in human neurons

1997 • 113 citations

Caspase-Dependent Apoptosis of Cells Expressing the Chemokine Receptor CXCR4 Is Induced by Cell Membrane-Associated Human Immunodeficiency Virus Type 1 Envelope Glycoprotein (gp120)

2000 • 107 citations

Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat

2004 • 105 citations

Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of μ and δ receptor activation on proliferation and neurite elongation

2000 • 103 citations

Apoptotic and Anti‐Apoptotic Synaptic Signaling Mechanisms

2000 • 94 citations

Mixed Lineage Kinase 3 (MLK3)-activated p38 MAP Kinase Mediates Transforming Growth Factor-β-induced Apoptosis in Hepatoma Cells

2004 • 91 citations

HIV‐1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid

1997 • 90 citations

Regional patterns of brain metabolites in AIDS dementia complex

2004 • 87 citations

Neuroimaging correlates of HIV-associated BBB compromise

2004 • 86 citations

Human Immunodeficiency Virus Type 1 Tat Protein Directly Activates Neuronal N -methyl- D -aspartate Receptors at an Allosteric Zinc-Sensitive Site

2003 • 83 citations

Regression of HIV encephalopathy and basal ganglia signal intensity abnormality at MR imaging in patients with AIDS after the initiation of protease inhibitor therapy.

1998 • 80 citations

Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.

2003 • 78 citations

Morphine Potentiates HIV‐1 gp120–Induced Neuronal Apoptosis

2005 • 73 citations

A novel action of minocycline: Inhibition of human immunodeficiency virus type 1 infection in microglia

2004 • 68 citations

Neuropathogenesis of central nervous system HIV-1 infection

2002 • 58 citations

Apoptotic and Antiapoptotic Effects of CXCR4: Is It a Matter of Intrinsic Efficacy? Implications for HIV Neuropathogenesis

2004 • 56 citations

HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-κB activation

2000 • 52 citations

Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis

2004 • 50 citations

Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells

1999 • 44 citations

HIV Tat Activates c-Jun Amino-terminal Kinase through an Oxidant-Dependent Mechanism

2001 • 44 citations

Assessment of neuronal density in the putamen in human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats

1995 • 42 citations

Review: Neuronal injury in HIV infection

1999 • 42 citations

Mixed lineage kinase 3 mediates gp120IIIB‐induced neurotoxicity

2002 • 38 citations

The JNK and p38 signal transduction following axotomy.

2001 • 38 citations

Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome C release and caspase-3 activation

2003 • 36 citations

Dysregulation of Mitogen-Activated Protein Kinase Signaling Pathways in Simian Immunodeficiency Virus Encephalitis

2004 • 34 citations

HIV-1 gp120-Induced Tubular Epithelial Cell Apoptosis Is Mediated Through p38-MAPK Phosphorylation

2002 • 28 citations

Bcl-2 enhances neurite extension via activation of c-Jun N-terminal kinase

2003 • 25 citations

Clinical Neurovirology

2003 • 24 citations

CD4 dependence of gp120IIIB-CXCR4 interaction is cell-type specific

2003 • 21 citations

Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus

2004 • 20 citations

Dynorphin A toxicity in striatal neurons via an α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism

2003 • 19 citations

The Mammalian Striatum and Neurotoxic Injury

2002 • 10 citations

HIV Meningitis and Dementia

2003 • 5 citations