Regulation of gene expression and its role in long-term memory and synaptic plasticity

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

Viable offspring derived from fetal and adult mammalian cells

1997 • 4,774 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

1996 • 1,272 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Genetic dissection of consolidated memory in Drosophila

1994 • 901 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

1995 • 639 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

1995 • 575 citations

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

1994 • 528 citations

Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training

1997 • 484 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

CREB and the formation of long-term memory

1996 • 399 citations

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

1994 • 394 citations

CREB: A mediator of long-term memory from mollusks to mammals

1994 • 371 citations

Spaced training induces normal long-term memory in CREB mutant mice

1997 • 357 citations

The CREB family of transcription activators

1992 • 298 citations

Dissection of memory formation: from behavioral pharmacology to molecular genetics

1995 • 277 citations

Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. III. CREB Is Necessary for Presynaptic Functional Plasticity

1996 • 236 citations

Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

1996 • 221 citations

Transcriptional regulation by CREB and its relatives

1993 • 197 citations

Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum

1996 • 195 citations

Cell Adhesion Molecules, CREB, and the Formation of New Synaptic Connections

1996 • 166 citations

Alternative Exon Splicing Controls a Translational Switch from Activator to Repressor Isoforms of Transcription Factor CREB during Spermatogenesis

1996 • 122 citations

A Drosophila CREB/CREM Homolog Encodes Multiple Isoforms, Including a Cyclic AMP-Dependent Protein Kinase-Responsive Transcriptional Activator and Antagonist

1995 • 108 citations

Protein phosphorylation in neuronal plasticity and gene expression

1995 • 107 citations

The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription.

1993 • 104 citations

G-protein βγ Subunits Mediate Specific Phosphorylation of the Protein-tyrosine Phosphatase SH-PTP1 Induced by Lysophosphatidic Acid

1996 • 45 citations

Electroconvulsive Seizure Increases the Expression of CREM (Cyclic AMP Response Element Modulator) and ICER (Inducible Cyclic AMP Early Repressor) in Rat Brain

1996 • 43 citations

A return to genetic dissection of memory in Drosophila.

1996 • 27 citations

Chapter 1 The gene knockout technology for the analysis of learning and memory, and neural development

1995 • 23 citations