Haemostatic changes in pregnancy

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Elevated Levels of Shed Membrane Microparticles With Procoagulant Potential in the Peripheral Circulating Blood of Patients With Acute Coronary Syndromes

2000 • 876 citations

Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin

2003 • 740 citations

Guidelines on the investigation and management of antiphospholipid syndrome

2012 • 725 citations

In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant

1999 • 720 citations

Haemostasis and Thrombosis.

1982 • 688 citations

Microparticles in cardiovascular diseases

2003 • 610 citations

Haemostasis in Normal Pregnancy

1984 • 595 citations

Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies

1998 • 492 citations

Haemostasis and Thrombosis

1994 • 446 citations

Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy

1998 • 377 citations

The prevalence and biologic significance of lupus anticoagulant and antic ardiolipin antibodies in a general obstetric population

1989 • 362 citations

Functional and immunologic protein S levels are decreased during pregnancy

1986 • 347 citations

Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors

1987 • 327 citations

The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent

1996 • 294 citations

Guidelines On The Investigation and Management Of The Antiphospholipid Syndrome

2000 • 294 citations

Changes in the plasma levels of vitamin K-dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception

1988 • 259 citations

Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis

1997 • 251 citations

Enhanced thrombin generation in normal and hypertensive pregnancy

1989 • 231 citations

Studies on Blood Coagulation and Fibrinolysis in Pregnancy, during Delivery and in the Puerperium

1981 • 229 citations

Activated Protein C Resistance (FV:Q506) and Pregnancy

1999 • 226 citations

Haemostasis and Thrombosis

1988 • 221 citations

Development of resistance to activated protein C during pregnancy

1995 • 205 citations

Platelet count at term pregnancy: a reappraisal of the threshold

2000 • 201 citations

Prostacyclin and Thromboxane Changes Predating Clinical Onset of Preeclampsia

1999 • 173 citations

Maternal thrombocytopenia at term: a population‐based study

2000 • 172 citations

TAFI antigen and D‐dimer levels during normal pregnancy and at delivery

2001 • 170 citations

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

1999 • 166 citations

Platelets in pregnancy: hyperdestruction in pregnancy.

1983 • 157 citations

Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium.

1992 • 148 citations

Microparticle subpopulations are increased in preeclampsia: Possible involvement in vascular dysfunction?

2002 • 148 citations

Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction

2003 • 143 citations

Arg⁵⁰⁶–Gln mutation in factor V and risk of thrombosis during pregnancy

1996 • 141 citations

Should anticardiolipin tests be performed in otherwise healthy pregnant women?

1991 • 133 citations

Changes in protein C and protein S levels in normal pregnancy

1995 • 133 citations

A Simple and Rapid Laboratory Method for Determination of Haemostasis Potential in Plasma

2001 • 130 citations

Isolation of a new specific plasminogen activator in hibitor from pregnancy plasma

1986 • 129 citations

Cellular Localisation in Placenta of Placental Type Plasminogen Activator Inhibitor

1986 • 126 citations

Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets

1987 • 125 citations

Circulating Procoagulant Microparticles in Women with Unexplained Pregnancy Loss: a New Insight

2001 • 119 citations

Changes in activated protein C resistance during normal pregnancy

1997 • 114 citations

Prospective Evaluation of Hemostatic System Activation and Thrombin Potential in Healthy Pregnant Women with and without Factor V Leiden

1999 • 114 citations

Acquired activated protein C resistance is common in cancer patients and is associated with venous thromboembolism

2001 • 102 citations

Gestational Thrombocytopenia

1999 • 99 citations

Plasma TAFI Antigen Variations in Healthy Subjects

2000 • 98 citations

Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations

2004 • 96 citations

Increased intravascular coagulation associated with pregnancy.

1990 • 93 citations

Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis

2004 • 93 citations

Plasma Fibrinopeptide A and Beta-Thromboglobulin in Pre-Eclampsia and Pregnancy Hypertension

1982 • 92 citations

Should anticardiolipin tests be performed in otherwise healthy pregnant women?

1991 • 84 citations

Predictive value of increased plasma levels of fibronectin in gestational hypertension

1989 • 83 citations

Fibrinolysis during normal human pregnancy: complex inter‐relationships between plasma levels of tissue plasminogen activator and inhibitors and the euglobulin clot lysis time

1988 • 83 citations

A Laboratory Method for Determination of Overall Haemostatic Potential in Plasma. I. Method Design and Preliminary Results

1999 • 83 citations

Enhanced Coagulation Activation in Preeclampsia: the Role of APC Resistance, Microparticles and Other Plasma Constituents

2002 • 72 citations

Changes in Blood Coagulation and Fibrinolysis in the Normal Puerperium

1985 • 71 citations

PLATELET LIFESPAN IN NORMAL PREGNANCY AS DETERMINED BY A NONRADIOISOTOPIC TECHNIQUE

1978 • 71 citations

A Longitudinal Study of the Relationships between Haemostatic, Lipid, and Oestradiol Changes during Normal Human Pregnancy

1999 • 70 citations

Uteroplacental Hemostasis in Intrauterine Fetal Growth Retardation

1999 • 67 citations

The coagulation and fibrinolytic enzyme system in pregnancy and in the puerperium

1982 • 66 citations

Plasma levels of von Willebrand factor and fibronectin as markers of persisting endothelial damage in preeclampsia

1995 • 66 citations

BLOOD CLOTTING ACTIVATION DURING NORMAL PREGNANCY

1996 • 66 citations

Platelet activation in the hypertensive disorders of pregnancy

2002 • 63 citations

Fibrinolytic parameters in normotensive pregnancy with intrauterine fetal growth retardation and in severe preeclampsia

1991 • 62 citations

Physiological coagulation inhibitors (protein S, protein C and antithrombin III) in severe preeclamptic states and in users of oral contraceptives

1988 • 61 citations

Haemostatic mechanisms in human placenta

2003 • 61 citations

Fibrinolytic Activity and Protein C in Preeclampsia

1986 • 58 citations

The Glasgow Outcome, APCR and Lipid (GOAL) Pregnancy Study: Significance of Pregnancy Associated Activated Protein C Resistance

2001 • 58 citations

Predictive Value of Plasma Thrombomodulin in Preeclampsia and Gestational Hypertension

1998 • 57 citations

Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome

1999 • 55 citations

Activated protein C sensitivity ratio in pregnant women at delivery

1996 • 53 citations

Changes in blood coagulation and fibrinolysis during the puerperium

1969 • 52 citations

The function of elevated plasma fibronectin in preeclampsia

1992 • 51 citations

Studies on phospholipid antibodies, APC-resistance and associated mutation in the coagulation factor V gene

1995 • 50 citations

Thrombin Regulation in Mother and Fetus During Pregnancy

1992 • 50 citations

Resistance to activated protein c: Evaluation of three functional assays

1994 • 47 citations

Reference interval of D-dimer in pregnant women

2001 • 44 citations

Comparison of protein S functional and antigenic assays in normal pregnancy

1996 • 43 citations

Progestin-Epidermal Growth Factor Regulation of Tissue Factor Expression during Decidualization of Human Endometrial Stromal Cells¹

2000 • 43 citations

The prevalence of autoantibodies and lupus anticoagulant in healthy pregnant women.

1990 • 42 citations

Antithrombin III in normal pregnancy

1982 • 41 citations

Anticardiolipin antibodies in unselected pregnant women. Relationship to fetal outcome.

1991 • 41 citations

Fluctuations in levels of antiphospholipid antibodies and increased coagulation activation markers in normal andheparin-treated antiphospholipid syndrome pregnancies

2002 • 39 citations

Alterations in the Coagulation and Fibrinolysis System in Pregnancy Labour and Puerperium, with Special Reference to a Possible Transitory State of Intravascular Coagulation during Labour

1978 • 39 citations

Effect of in vitro fertilization treatment and subsequent pregnancy on the protein C pathway

2001 • 34 citations

Placental basal plate formation is associated with fibrin deposition in decidual veins at sites of trophoblast cell invasion

2002 • 32 citations

Thrombin-inhibitor complexes in the blood during and after delivery

1996 • 32 citations

Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1.

1998 • 31 citations

Platelet disorders in pregnancy

2001 • 31 citations

[Activated protein C resistance].

1998 • 31 citations

t-PA activity in peripheral blood obtained from pregnant women

1994 • 29 citations

Protein C levels in late pregnancy, postpartum and in women on oral contraceptives

1985 • 29 citations

Thrombomodulin Levels during Normal Pregnancy, at Delivery and in the Postpartum: Comparison with Tissue-type Plasminogen Activator and Plasminogen Activator Inhibitor-1

1998 • 27 citations

Quantitation of thrombin-antithrombin III complexes in human blood

1977 • 27 citations

Does Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Contribute to Impairment of Fibrinolysis in Patients with Preeclampsia and/or Intrauterine Fetal Growth Retardation?

2002 • 26 citations

Transamidating enzymes in maternal plasma and placenta in human pregnancies complicated by intrauterine growth retardation.

1980 • 25 citations

The assay of overall haemostasis potential used to monitor the low molecular mass (weight) heparin, dalteparin, treatment in pregnant women with previous thromboembolism

2002 • 24 citations

Reactive thrombocytosis after caesarean section and vaginal delivery: implications for maternal thromboembolism and its prevention

2000 • 23 citations

Procoagulant Microparticles: New Insights and Opportunities in Pregnancy Loss?

2001 • 23 citations

The effect of prophylactic heparin treatment on enhanced thrombin generation in pregnancy

1993 • 23 citations

Coagulation Problems during Pregnancy

1985 • 21 citations

Coagulation Problems During Pregnancy

1985 • 21 citations

ACQUIRED ACTIVATED PROTEIN C RESISTANCE IN PREGNANCY

1996 • 20 citations

Variability of the response to activated protein C during normal pregnancy

1997 • 18 citations

Decrease in protein C inhibitor activity and acquired APC resistance during normal pregnancy.

2000 • 14 citations

Post partum platelet count in maternal blood

1994 • 11 citations

Soluble fibrin in plasma as a sign of activated coagulation in patients with pregnancy complications

1998 • 10 citations

Correlation between Grade III Placenta and Plasma Antithrombin III Activity in Full Term Pregnancy

2001 • 9 citations

Reactivity against phospholipids during pregnancy

1998 • 7 citations

Soluble fibrin in plasma as a sign of activated coagulation in patients with pregnancy complications

1998 • 4 citations

Decrease in Plasminogen Activator Inhibitor Type 2 Related More to Placental Function and Intrauterine Fetal Growth than to Severity of Preeclampsia

1996 • 1 citations

Deleted Work

1955 • 0 citations