Transcriptional regulation and spatial patterning in Drosophila

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

oskar organizes the germ plasm and directs localization of the posterior determinant nanos

1991 • 804 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Regulation of even-skipped stripe 2 in the Drosophila embryo.

1992 • 522 citations

Characterization and localization of the even-skipped protein of Drosophila.

1987 • 496 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.

1988 • 471 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Control elements of the Drosophila segmentation gene fushi tarazu

1985 • 404 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

Localization of nanos RNA controls embryonic polarity

1992 • 391 citations

Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box

1986 • 380 citations

Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres

1988 • 366 citations

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

1991 • 361 citations

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily

1990 • 361 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

The Drosophila gene torso encodes a putative receptor tyrosine kinase

1989 • 327 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers

1987 • 312 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

FTZ-F1, a Steroid Hormone Receptor-like Protein Implicated in the Activation of fushi tarazu

1991 • 292 citations

Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

1989 • 273 citations

Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila

1989 • 270 citations

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo

1990 • 258 citations

Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.

1987 • 247 citations

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

1989 • 245 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product

1991 • 236 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila

1991 • 229 citations

The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.

1990 • 218 citations

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1993 • 217 citations

Two Gap Genes Mediate Maternal Terminal Pattern Information in Drosophila

1990 • 214 citations

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers

1991 • 214 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.

1992 • 203 citations

A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression.

1990 • 186 citations

Concentration-dependent transcriptional activation or repression by Krüppel from a single binding site

1991 • 166 citations

Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo

1990 • 160 citations

Mutually repressive interactions between the gap genes giant and Krüppel define middle body regions of the Drosophila embryo

1991 • 159 citations

Spatial regulation of the gap gene giant during Drosophila development

1991 • 157 citations

Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes

1991 • 152 citations

Competition for Overlapping Sites in the Regulatory Region of the Drosophila Gene Krüppel

1992 • 145 citations

The Drosophila pumilio gene: an unusually long transcription unit and an unusual protein

1992 • 144 citations

Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila

1987 • 143 citations

Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting

1991 • 141 citations

Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryo

1989 • 140 citations

Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the drosophila embryo

1990 • 137 citations

Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo

1991 • 137 citations

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.

1991 • 132 citations

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene.

1988 • 131 citations

Pole region-dependent repression of the Drosophila gap gene Krüppel by maternal gene products

1987 • 124 citations

Making stripes in the Drosophila embryo

1990 • 124 citations

Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila.

1989 • 123 citations

bicoid and the terminal system activate tailless expression in the early Drosophila embryo

1992 • 121 citations

Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes.

1991 • 117 citations

The molecular genetics of head development in Drosophila melanogaster

1991 • 113 citations

The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes

1992 • 112 citations

Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity

1992 • 112 citations

Dual Role of the Drosophila Pattern Gene tailless in Embryonic Termini

1991 • 111 citations

Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback.

1991 • 110 citations

Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells.

1991 • 107 citations

Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo.

1992 • 104 citations

The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila

1993 • 100 citations

Drosophila development

1989 • 95 citations

Transcriptional control of Drosophila fushi tarazu zebra stripe expression.

1989 • 95 citations

Genes of theDrosophilamaternal dorsal group control the specific expression of the zygotic genetwistin presumptive mesodermal cells

1987 • 93 citations

Drosophila headlines

1991 • 92 citations

Decoding positional information: regulation of the pair-rule gene hairy

1990 • 86 citations

Spatial Control of the Gap Gene knirps in the Drosophila Embryo by Posterior Morphogen System

1992 • 84 citations

The same dorsal binding site mediates both activation and repression in a context-dependent manner.

1992 • 76 citations

Drosophila melanogaster homologs of the raf oncogene.

1987 • 70 citations

Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity

1990 • 59 citations

Control of tailless expression by bicoid, dorsal and synergistically interacting terminal system regulatory elements

1993 • 54 citations

Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu

1992 • 52 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 24 citations

Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators

1992 • 20 citations

Characterization of downstream elements in a Raf-1 pathway.

1993 • 19 citations