The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1997 • 657 citations

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

1998 • 555 citations

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

2001 • 516 citations

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

2001 • 492 citations

Chromosome translocations in multiple myeloma

2001 • 481 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

FGFR activation in skeletal disorders: Too much of a good thing

1997 • 319 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

The Molecular and Genetic Basis of Fibroblast Growth Factor Receptor 3 Disorders: The Achondroplasia Family of Skeletal Dysplasias, Muenke Craniosynostosis, and Crouzon Syndrome with Acanthosis Nigricans*

2000 • 299 citations

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

2001 • 296 citations

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

2000 • 261 citations

The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses.

2000 • 242 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

A Novel Chromosomal Translocation t(4; 14)(p16.3; q32) in Multiple Myeloma Involves the Fibroblast Growth-Factor Receptor 3 Gene

1997 • 216 citations

14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myélome.

1999 • 206 citations

The Molecular and Genetic Basis of Fibroblast Growth Factor Receptor 3 Disorders: The Achondroplasia Family of Skeletal Dysplasias, Muenke Craniosynostosis, and Crouzon Syndrome with Acanthosis Nigricans

2000 • 190 citations

High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

2001 • 190 citations

Interleukin-6 is a growth factor for nonmalignant human plasmablasts

2001 • 181 citations

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

2000 • 172 citations

Mcl‐1 and Bcl‐x_L are co‐regulated by IL‐6 in human myeloma cells

1999 • 157 citations

p53 and RAS gene mutations in multiple myeloma.

1992 • 157 citations

Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

2001 • 110 citations

The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

2001 • 98 citations

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts.

2000 • 94 citations

ZNF198–FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain

2000 • 76 citations

Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)

2001 • 70 citations

Basic fibroblast growth factor and hematopoiesis.

1995 • 62 citations

Detection of t(4;14)(p16.3;q32) Chromosomal Translocation in Multiple Myeloma by Double-Color Fluorescent In Situ Hybridization

1999 • 62 citations

8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways

2001 • 60 citations

Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.

1997 • 59 citations

Translocation t(4;14)(p16.3;q32) Is a Recurrent Genetic Lesion in Primary Amyloidosis

2001 • 37 citations

Establishment and characterization of a human stroma-dependent myeloma cell line (MM5.1) and its stroma-independent variant (MM5.2)

1997 • 30 citations

Interphase Detection of t(4;14)(p16.3;q32.3) by In Situ Hybridization and FGFR3 Overexpression in Plasma Cell Malignancies

2000 • 25 citations

Update of gp130 cytokines in multiple myeloma

1998 • 17 citations