The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

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2001 • 133,517 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

1996 • 867 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas

1999 • 697 citations

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1997 • 657 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

1995 • 602 citations

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

1998 • 555 citations

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1996 • 500 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

1996 • 389 citations

Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple Myeloma

1998 • 388 citations

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1997 • 351 citations

Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage.

1993 • 321 citations

FGFR activation in skeletal disorders: Too much of a good thing

1997 • 319 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

1997 • 299 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

A Novel Chromosomal Translocation t(4; 14)(p16.3; q32) in Multiple Myeloma Involves the Fibroblast Growth-Factor Receptor 3 Gene

1997 • 216 citations

The Ig Heavy Chain Gene Is Frequently Involved in Chromosomal Translocations in Multiple Myeloma and Plasma Cell Leukemia as Detected by In Situ Hybridization

1997 • 198 citations

High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies.

1998 • 187 citations

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

2000 • 172 citations

Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II

1996 • 172 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.

1993 • 145 citations

MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands.

1994 • 95 citations

Increased expression of fibroblast growth factor 8 in human breast cancer

1999 • 80 citations

Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines

1999 • 77 citations

Activation of FGF receptors by mutations in the transmembrane domain

1997 • 74 citations

Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo

1998 • 71 citations

T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 • 68 citations

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.

1993 • 65 citations

Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes.

1994 • 64 citations

Immunology Methods Manual: The Comprehensive Sourcebook of Techniques

1997 • 48 citations

Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6

1992 • 47 citations

Retroviral Vectors for Production of Interleukin‐12 in the Bone Marrow to Induce a Graft‐Versus‐Leukemia Effecta

1996 • 43 citations

Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures

1999 • 31 citations