Ischemia and Reperfusion Injury in Liver Transplantation

Integrins

2002 • 8,127 citations

Toll-like receptor signalling

2004 • 7,983 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Fibronectin at a glance

2002 • 1,831 citations

Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996

2000 • 1,803 citations

PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD STORAGE

1988 • 1,366 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

2005 • 1,052 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

NEUTROPHIL INFILTRATION AS AN IMPORTANT FACTOR IN LIVER ISCHEMIA AND REPERFUSION INJURY

1993 • 799 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation

2004 • 592 citations

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

2005 • 544 citations

Protective strategies against ischemic injury of the liver

2003 • 531 citations

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

2002 • 495 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury

2000 • 446 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway

2004 • 442 citations

Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure

2001 • 419 citations

Kupffer cell activation and endothelial cell damage after storage of rat livers: Effects of reperfusion

1991 • 409 citations

Hepatic ischemia/reperfusion injury—a fresh look

2003 • 407 citations

THE BENEFICIAL EFFECT OF HUMAN RECOMBINANT SUPEROXIDE DISMUTASE ON ACUTE AND CHRONIC REJECTION EVENTS IN RECIPIENTS OF CADAVERIC RENAL TRANSPLANTS

1994 • 392 citations

Toll‐like receptors, endogenous ligands, and systemic autoimmune disease

2005 • 391 citations

Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge

1995 • 368 citations

CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.

1997 • 365 citations

Reperfusion injury to endothelial cells following cold ischemic storage of rat livers

1989 • 356 citations

Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells

2005 • 356 citations

Noninvasive Measures of Liver Fibrosis

2006 • 349 citations

Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice

2000 • 344 citations

Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation

1998 • 337 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation

2006 • 286 citations

The Dynamics of Proteins

1986 • 281 citations

Ischemic injury in liver transplantation: Difference in injury sites between warm and cold ischemia in rats

1992 • 271 citations

The Role of Postischemic Reperfusion Injury and Other Nonantigen-Dependent Inflammatory Pathways in Transplantation

2005 • 257 citations

Liver Transplantation After Organ Preservation With Normothermic Extracorporeal Perfusion

2001 • 251 citations

A prospective, randomized, clinical trial of intraoperative versus postoperative thymoglobulin in adult cadaveric renal transplant recipients1

2003 • 245 citations

Therapeutic approaches for ischemia/reperfusion injury in the liver

1999 • 234 citations

INFLUENCE OF OXYGEN-DERIVED FREE RADICAL SCAVENGERS ON ISCHEMIC LIVERS

1985 • 230 citations

Extracorporeal Support for Organ Donation after Cardiac Death Effectively Expands the Donor Pool

2005 • 230 citations

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.

1997 • 228 citations

What distinguishes tenascin from fibronectin?

1990 • 219 citations

p38-MAPK Signals Survival by Phosphorylation of Caspase-8 and Caspase-3 in Human Neutrophils

2004 • 205 citations

Heme oxygenase-1 system in organ transplantation1

2002 • 199 citations

Successful extracorporeal porcine liver perfusion for 72 hr1

2002 • 190 citations

IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules

1998 • 190 citations

Heme Oxygenase-1 Overexpression Protects Rat Livers from Ischemia/Reperfusion Injury with Extended Cold Preservation

2001 • 178 citations

Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice

2004 • 175 citations

Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury

2006 • 174 citations

Biliverdin therapy protects rat livers from ischemia and reperfusion injury

2004 • 163 citations

Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin

2005 • 154 citations

Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury1

2002 • 153 citations

Tenascin-C Modulates Matrix Contraction via Focal Adhesion Kinase– and Rho-mediated Signaling Pathways

2002 • 139 citations

CORRELATION BETWEEN CELLULAR ATP LEVEL AND BILE EXCRETION IN THE RAT LIVER

1985 • 122 citations

CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection

2002 • 122 citations

Reduction of Hepatic Ischemia/Reperfusion Injury by a Soluble P-Selectin Glycoprotein Ligand-1

1998 • 116 citations

Deficiency of tenascin‐C attenuates liver fibrosis in immune‐mediated chronic hepatitis in mice

2006 • 115 citations

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury

2006 • 114 citations

Toll‐like receptor interactions: tolerance of MyD88‐dependent cytokines but enhancement of MyD88‐independent interferon‐β production

2006 • 110 citations

Cold liver ischemia-reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice

2000 • 109 citations

Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection

2003 • 109 citations

Current status of ischemia and reperfusion injury in the liver

2000 • 107 citations

TIM Family of Genes in Immunity and Tolerance

2006 • 104 citations

Potential oncogenic action of tenascin-C in tumorigenesis

2005 • 102 citations

Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro.

2002 • 100 citations

Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice.

2004 • 97 citations

Tenascin is a cytoadhesive extracellular matrix component of the human hematopoietic microenvironment.

1993 • 94 citations

Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor

1996 • 91 citations

Lymphocyte Adherence in the Reperfused Rat Liver: Mechanisms and Effects

1993 • 89 citations

Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model

1998 • 87 citations

A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system

2002 • 87 citations

Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury

2005 • 82 citations

Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion

2001 • 78 citations

FTY720 Pretreatment Reduces Warm Hepatic Ischemia Reperfusion Injury Through Inhibition of T-Lymphocyte Infiltration

2002 • 72 citations

IL-13 Activates STAT6 and Inhibits Liver Injury Induced by Ischemia/Reperfusion

1999 • 64 citations

P‐Selectin Glycoprotein Ligand‐1 (rPSGL‐Ig)‐Mediated Blockade of CD62 Selectin Molecules Protects Rat Steatotic Liver Grafts from Ischemia/Reperfusion Injury

2002 • 63 citations

Endoplasmic and Vascular Surface Activation During Organ Preservation: Refining Upon the Benefits of Machine Perfusion

2006 • 62 citations

Reduced hepatic ischemia/reperfusion injury by IL-4: potential anti-inflammatory role of STAT6

2000 • 62 citations

EGF-Like Domain of Tenascin-C Is Proapoptotic for Cultured Smooth Muscle Cells

2004 • 61 citations

PRECONDITIONING OF DONOR LIVERS WITH PROSTAGLANDIN I2 BEFORE RETRIEVAL DECREASES HEPATOCELLULAR ISCHEMIA-REPERFUSION INJURY

1999 • 60 citations

Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury

1992 • 59 citations

Molecular Characterization of Rat Leukocyte P-Selectin Glycoprotein Ligand-1 and Effect of Its Blockade: Protection from Ischemia-Reperfusion Injury in Liver Transplantation

2006 • 55 citations

Anti-Endotoxin Monoclonal Antibodies are Protective against Hepatic Ischemia/Reperfusion Injury in Steatotic Mice

2004 • 51 citations

Fibronectin-α4β1 Integrin-Mediated Blockade Protects Genetically Fat Zucker Rat Livers from Ischemia/Reperfusion Injury

2003 • 51 citations

Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation

2005 • 48 citations

Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues.

1993 • 48 citations

CD18 integrin and CD54-dependent neutrophil adhesion to cytokine-stimulated human hepatocytes

1997 • 48 citations

A prospective randomized trial of N-acetyl cysteine administration during cold preservation of the donor liver for transplantation

2005 • 42 citations

Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury

2003 • 39 citations

HEGPOL: Randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]

2005 • 38 citations

Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion1

2003 • 35 citations

Expression of tenascin in thymus and thymic nonlymphoid cells.

1994 • 22 citations

Fibronectin in Immune Responses in Organ Transplant Recipients

2000 • 22 citations

Emerging evidence that molecules expressed by mammalian tissue grafts are recognized by the innate immune system

2002 • 15 citations

Extracellular Matrix and Organ Transplantation

2004 • 2 citations