Extracellular Matrix and Organ Transplantation

Integrins

2002 • 8,127 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Integrin Signaling

1999 • 3,705 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

1994 • 1,190 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Textbook of Biochemistry with Clinical Correlations

1983 • 971 citations

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

1997 • 956 citations

Laminin and Other Basement Membrane Components

1987 • 900 citations

The molecular elasticity of the extracellular matrix protein tenascin

1998 • 835 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Matrix Metalloproteinases

2002 • 725 citations

Supramolecular assembly of basement membranes

1996 • 693 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 • 606 citations

Tenascin: An Extracellular Matrix Protein Prominent in Specialized Embryonic Tissues and Tumors

1989 • 604 citations

Induction of tenascin in healing wounds.

1988 • 563 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

The cell biology of leukocyte-mediated proteolysis

1999 • 424 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions

1993 • 401 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Laminin isoforms in tumor invasion, angiogenesis and metastasis

2002 • 388 citations

Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo.

1998 • 368 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors.

1989 • 339 citations

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

1996 • 331 citations

Tenascin-C in development and disease: gene regulation and cell function

2000 • 316 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Targeted Mutations in Cell Adhesion Genes: What Have We Learned from Them?

1996 • 295 citations

Differential expression of the ed sequence-containing form of cellular fibronectin in embryonic and adult human tissues

1987 • 251 citations

Matrix-Dependent Mechanism of Neutrophil-Mediated Release and Activation of Matrix Metalloproteinase 9 in Myocardial Ischemia/Reperfusion

2001 • 229 citations

Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.

1996 • 220 citations

Collagen polymorphism in the lungAn immunochemical study of pulmonary fibrosis

1980 • 220 citations

Analysis of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrins in cell--collagen interactions: identification of conformation dependent alpha 1 beta 1 binding sites in collagen type I.

1992 • 218 citations

Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2

2000 • 218 citations

Interaction of type IV collagen with the isolated integrins α1β1 and α2β1

1993 • 215 citations

Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse

2002 • 215 citations

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

2000 • 215 citations

The EIIIA Segment of Fibronectin Is a Ligand for Integrins α9β1 and α4β1Providing a Novel Mechanism for Regulating Cell Adhesion by Alternative Splicing

2002 • 209 citations

Insights into MMP‐TIMP Interactions

1999 • 204 citations

The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes

1996 • 193 citations

Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.

1993 • 191 citations

Evidence for Immune Responses to a Self-Antigen in Lung Transplantation: Role of Type V Collagen-Specific T Cells in the Pathogenesis of Lung Allograft Rejection

2002 • 182 citations

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

1999 • 178 citations

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

2001 • 173 citations

Mesodermal development in mouse embryos mutant for fibronectin

1996 • 170 citations

A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon.

1984 • 169 citations

Tenascin, an extracellular matrix protein, exerts immunomodulatory activities.

1989 • 167 citations

Matrix Metalloproteinase-9 Deficiency Impairs Cellular Infiltration and Bronchial Hyperresponsiveness during Allergen-Induced Airway Inflammation

2002 • 163 citations

Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi.

1992 • 162 citations

Fibronectin: from gene to protein

1991 • 161 citations

The Collagen Superfamily

1995 • 160 citations

Immunochemical Characterization of the Basement Membrane Glycoprotein Laminin

1979 • 153 citations

Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

1993 • 145 citations

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1)

1994 • 142 citations

Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.

1993 • 128 citations

In vivo blockade of tumor necrosis factor-alpha in cholesterol-fed rabbits after cardiac transplant inhibits acute coronary artery neointimal formation.

1994 • 123 citations

Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin.

1990 • 122 citations

Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.

1994 • 116 citations

Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance1

2002 • 112 citations

A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

1995 • 111 citations

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

1994 • 107 citations

TREATMENT WITH ANTI-VASCULAR CELL ADHESION MOLECULE 1 MONOCLONAL ANTIBODY INDUCES LONG-TERM MURINE CARDIAC ALLOGRAFT ACCEPTANCE

1993 • 99 citations

The tenascin gene family.

1994 • 98 citations

Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice.

1994 • 96 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Tenascin-C

1997 • 92 citations

Regulation of Mitogen-activated Protein Kinase Activation by the Cytoplasmic Domain of the α6 Integrin Subunit

1998 • 91 citations

Metalloproteinases and collagenase inhibitors in rheumatoid synovial fluid

1984 • 86 citations

Interplay of T cells and cytokines in the context of enzymatically modified extracellular matrix

1996 • 80 citations

A Cytological Study of the Alimentary Tract of the Domestic Fowl (Gallus domesticus)

1947 • 80 citations

Interleukin 15 Induces Endothelial Hyaluronan Expression in Vitro and Promotes Activated T Cell Extravasation through a Cd44-Dependent Pathway in Vivo

1999 • 78 citations

Inhibition of T cell activation by the extracellular matrix protein tenascin.

1994 • 71 citations

Tenascin Supports Lymphocyte Rolling

1997 • 70 citations

Fibronectin expression in the normal and hypertrophic rat heart.

1992 • 67 citations

Fibronectin Type III5 Repeat Contains a Novel Cell Adhesion Sequence, KLDAPT, Which Binds Activated α4β1 and α4β7 Integrins

1997 • 67 citations

Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration.

1994 • 65 citations

CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.

1997 • 63 citations

Tenascin-C inhibits β1 integrin-dependent T lymphocyte adhesion to fibronectin through the binding of its fnIII 1 – 5 repeats to fibronectin

1999 • 60 citations

The leukocyte β1 integrins

1995 • 58 citations

Unique changes in interstitial extracellular matrix composition are associated with rejection and cyclosporine toxicity in human renal allograft biopsies

1999 • 57 citations

Anti-TNF-alpha treatment down-regulates the expression of fibronectin and decreases cellular infiltration of cardiac allografts in rats.

1995 • 57 citations

Mechanisms of Fibronectin and Integrin Function during Cell Adhesion and Migration

1992 • 57 citations

PROLONGATION OF RAT ISLET ALLOGRAFT SURVIVAL BY TREATMENT WITH MONOCLONAL ANTIBODIES AGAINST VLA-4 AND LFA-1

1995 • 55 citations

EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus.

1991 • 54 citations

Expression of alternatively spliced fibronectin variants during remodeling in proliferative glomerulonephritis.

1995 • 54 citations

Reciprocal induction of tumor necrosis factor‐α and interleukin‐β activity mediates fibronectin synthesis in coronary artery smooth muscle cells

1995 • 51 citations

Fibronectin-α4β1 Integrin-Mediated Blockade Protects Genetically Fat Zucker Rat Livers from Ischemia/Reperfusion Injury

2003 • 51 citations

Plasmin-induced proteolysis of tenascin-C: modulation by T lymphocyte-derived urokinase-type plasminogen activator and effect on T lymphocyte adhesion, activation, and cell clustering.

1997 • 50 citations

MATRIX METALLOPROTEINASES CORRELATE WITH ALVEOLAR-CAPILLARY PERMEABILITY ALTERATION IN LUNG ISCHEMIA-REPERFUSION INJURY

2000 • 49 citations

FIBROSIS IN CHRONIC REJECTION OF HUMAN LIVER ALLOGRAFTS

1996 • 48 citations

Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues.

1993 • 48 citations

Contribution of lymphocyte function-associated-1/intercellular adhesion molecule-1 binding to the adhesion/signaling cascade of cytotoxic T lymphocyte activation.

1994 • 46 citations

Extracellular matrix components of the mouse thymic microenvironment. III. Thymic epithelial cells express the VLA6 complex that is involved in laminin-mediated interactions with thymocytes

1993 • 45 citations

Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts.

1997 • 44 citations

THE EXPRESSION OF EXTRACELLULAR MATRIX PROTEINS DURING ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS

1994 • 43 citations

Myocardial Ischemic Injury After Heart Transplantation Is Associated With Upregulation of Vitronectin Receptor (α _v β ₃ ), Activation of the Matrix Metalloproteinase Induction System, and Subsequent Development of Coronary Vasculopathy

2002 • 42 citations

Distribution of integrins on human peripheral blood mononuclear cells

1989 • 41 citations

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

1997 • 40 citations

THE EXPRESSION OF EXTRACELLULAR MATRIX PROTEINS DURING ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS

1994 • 39 citations

Lymphocyte traffic is modified in vivo by anti-laminin antibody.

1991 • 37 citations

BLOCKADE OF VERY LATE ANTIGEN-4 INTEGRIN BINDING TO FIBRONECTIN IN ALLOGRAFT RECIPIENTS

1998 • 35 citations

Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages.

1993 • 33 citations

BLOCKADE OF VERY LATE ANTIGEN-4 INTEGRIN BINDING TO FIBRONECTIN IN ALLOGRAFT RECIPIENTS

1998 • 33 citations

The amino-terminal 29- and 72-Kd fragments of fibronectin mediate selective monocyte recruitment

1990 • 31 citations

Embryonic fibronectin isoforms are synthesized in crescents in experimental autoimmune glomerulonephritis.

1995 • 29 citations

Involvement of laminin and its receptor in abrogation of heart graft rejection by autoreactive T cells from Trypanosoma cruzi-infected mice.

1997 • 26 citations

Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.

1997 • 26 citations

Fibronectin induces phosphorylation of a 120‐kDa protein and synergizes with the T cell receptor to activate cytotoxic T cell clones

1995 • 26 citations

Augmentation of mature CD4+ T cell responses to isolated antigenic class II proteins by fibronectin and intercellular adhesion molecule-1.

1997 • 25 citations

Lymphocyte transendothelial migration toward smooth muscle cells in interleukin‐1 β‐stimulated co‐cultures is related to fibronectin interactions with α₄β₁ and α₅β₁ integrins

1995 • 23 citations

Circulating levels of matrix metalloproteinases in heart transplant recipients

2000 • 22 citations

IMMUNOMODULATORY FUNCTIONS OF HYALURONATE IN THE LEW-TO-F344 MODEL OF CHRONIC CARDIAC ALLOGRAFT REJECTION

1999 • 22 citations

Cell adhesion and human disease

1996 • 20 citations

EXTRACELLULAR MATRIX PROTEINS IN ORGAN TRANSPLANTATION1

2000 • 20 citations

Extracellular matrix components of the mouse thymic microenvironment

1991 • 20 citations

DOWN-MODULATION OF HOST REACTIVITY BY ANTI-CD44 IN SKIN TRANSPLANTATION1

1998 • 20 citations

??4 INTEGRIN IN ISLET ALLOGRAFT REJECTION1

2001 • 18 citations

Fibronectin-Mononuclear Cell Interactions Regulate Type 1 Helper T Cell Cytokine Network in Tolerant Transplant Recipients

2000 • 17 citations

Local antilaminin antibody treatment alters the rejection pattern of murine cardiac allografts: correlation between cellular infiltration and extracellular matrix1

2002 • 15 citations

Lymphocyte Traffic and Positioning in Vivo: An Expande Role for the ECM, the VLA Proteins and the Cytokines

1994 • 12 citations

Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages.

1995 • 7 citations

Changes at the extracellular matrix during acute and chronic rejection in human liver transplantation

1998 • 7 citations

Increased tenascin expression is an early feature of the development of transplant renal arteriopathy in humans

1996 • 5 citations

Increased tenascin expression is an early feature of the development of transplant renal arteriopathy in humans

1996 • 5 citations

Cell adhesion and human disease. Chairman's introduction.

1995 • 2 citations