Neurotrophin-4: The odd one out in the neurotrophin family

Trophic factors and neuronal survival

1989 • 1,631 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF

1995 • 572 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

Neurotrophin-6 is a new member of the nerve growth factor family

1994 • 404 citations

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1995 • 381 citations

Muscle-Derived Neurotrophin-4 as an Activity-Dependent Trophic Signal for Adult Motor Neurons

1995 • 377 citations

Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

1994 • 374 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

1993 • 333 citations

The trk B tyrosine protein kinase is a receptor for neurotrophin-4

1992 • 326 citations

Widespread and Developmentally Regulated Expression of Neurotrophin‐4 mRNA in Rat Brain and Peripheral Tissues

1993 • 256 citations

Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins

1995 • 217 citations

Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain

1993 • 212 citations

Dependence on p75 for Innervation of Some Sympathetic Targets

1994 • 199 citations

1,25-Dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes

1994 • 196 citations

In Situ Hybridization of trkB and trkC Receptor mRNA in Rat Forebrain and Association with High‐affinity Binding of [¹²⁵I]BDNF, [¹²⁵I]NT‐4/5 and [¹²⁵I]NT‐3

1994 • 190 citations

Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation

1995 • 172 citations

Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.

1994 • 172 citations

Neurotrophic factors: From structure-function studies to designing effective therapeutics

1995 • 137 citations

Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.

1995 • 131 citations

Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity

1995 • 125 citations

Neurotrophic factors: An evolutionary perspective

1994 • 121 citations

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.

1994 • 120 citations

The Neurotrophins NT-4/5 and BDNF Augment Serotonin, Dopamine, and GABAergic Systems during Behaviorally Effective Infusions to the Substantia Nigra

1994 • 119 citations

Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4.

1994 • 116 citations

Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

1993 • 110 citations

Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures

1994 • 108 citations

Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion

1993 • 106 citations

Neurotrophin‐4/5 Promotes Survival and Differentiation of Rat Striatal Neurons Developing in Culture

1994 • 95 citations

Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells

1994 • 90 citations

Brain‐Derived Neurotrophic Factor Is More Highly Conserved in Structure and Function than Nerve Growth Factor During Vertebrate Evolution

1992 • 74 citations

Effects of BDNF and NT‐4/5 on Striatonigral Neuropeptides or Nigral GABA Neurons In Vivo

1996 • 67 citations

Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB

1995 • 62 citations

Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture

1994 • 54 citations

Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury.

1993 • 53 citations

Characterization and crystallization of recombinant human neurotrophin-4.

1994 • 42 citations

Brain-derived neurotrophic factor and modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum

1995 • 33 citations

Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins

1992 • 26 citations

Expression of neurotrophin-4 mRNA during oogenesis in Xenopus laevis.

1992 • 22 citations