Untersuchungen zur Biosynthese von Antibiotica

Investigation of complex networks of spin-spin coupling by two-dimensional NMR

1981 • 1,223 citations

Macrolide antibiotics. Chemistry, biology, and practice

1985 • 482 citations

Correlation of proton chemical shifts by two-dimensional Fourier transform NMR

1981 • 466 citations

Chemistry and Biochemistry of Microbial α‐Glucosidase Inhibitors

1981 • 461 citations

The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis

1976 • 383 citations

The Biology of the actinomycetes

1984 • 372 citations

Production of ‘hybrid’ antibiotics by genetic engineering

1985 • 364 citations

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

1984 • 358 citations

Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity.

1984 • 322 citations

Stoffwechselprodukte von Mikroorganismen

1971 • 318 citations

Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)

1979 • 197 citations

Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered.

1985 • 192 citations

Advances in Streptomyces coelicolor genetics

1973 • 182 citations

The Structure of Thiostrepton

1970 • 176 citations

Asymmetric Methyl Groups: Preparation and Detection of Chiral Methyl Groups

1969 • 165 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

Interpretations of enzyme reaction stereospecificity

1975 • 160 citations

Chemie und Biochemie mikrobieller α‐Glucosidasen‐Inhibitoren

1981 • 146 citations

Nonribosomal polypeptide synthesis on polyenzyme templates

1973 • 145 citations

STUDIES ON VALIDAMYCINS, NEW ANTIBIOTICS. I

1970 • 145 citations

Mutational cloning in Streptomyces and the isolation of antibiotic production genes

1983 • 138 citations

Studies on validamycins, new antibiotics. I. Streptomyces hygroscopicus var. limoneus nov. var., validamycin-producing organism.

1970 • 131 citations

Structure of boromycin

1971 • 122 citations

Regulation of Secondary Metabolite Formation

2007 • 119 citations

Studies on marine microorganisms. V. A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud.

1976 • 119 citations

Stoffwechselprodukte von Mikroorganismen. 57. Mitteilung. Boromycin

1967 • 119 citations

Highly modified cysteine-containing antibiotics. Chemical structure and configuration of nosiheptide

1977 • 116 citations

Omega-cyclohexyl fatty acids in acidophilic thermophilic bacteria. Studies on their presence, structure, and biosynthesis using precursors labeled with stable isotopes and radioisotopes.

1975 • 111 citations

Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

1993 • 111 citations

Self-cloning in Streptomyces griseus of an str gene cluster for streptomycin biosynthesis and streptomycin resistance

1985 • 109 citations

Structure of aplasmomycin.

1977 • 108 citations

Nosiheptide, a sulfur-containing peptide antibiotic isolated fromStreptomyces actuosus 40037

1980 • 96 citations

NANAOMYCINS A AND B*, NEW ANTIBIOTICS PRODUCED BY A STRAIN OF STREPTOMYCES

1974 • 96 citations

Synthesis and Configurational Assay of Asymmetric Methyl Groups

1970 • 94 citations

Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain

1986 • 91 citations

Untersuchungen zur struktur des α-d-glucosidaseinhibitors acarbose

1984 • 91 citations

Stereochemistry of Pyruvate Kinase, Pyruvate Carboxylase, and Malate Enzyme Reactions

1970 • 90 citations

[45] Tyrocidine synthetase system

1975 • 88 citations

Biosynthesis of Small Peptides

1974 • 86 citations

Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties.

1975 • 83 citations

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.

1987 • 79 citations

Total synthesis of aplasmomycin

1982 • 79 citations

Nanaomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis.

1975 • 78 citations

Stereochemistry of the myo-inositol-1-phosphate synthase reaction.

1980 • 77 citations

The structure of asukamycin, a possible shunt metabolite from 3-dehydroquinic acid in the shikimate pathway

1979 • 76 citations

Rifamycin Biosynthesis Studied with 13C Enriched Precursors and Carbon Magnetic Resonance

1973 • 75 citations

Catalytic Aspects of Enzymatic Racemization

1976 • 75 citations

Stoffwechselprodukte von Mikroorganismen 73. Mitteilung [1] Chlorothricin und Des‐chlorothoricin

1969 • 74 citations

Occurrence of .OMEGA.-cyclohexyl fatty acids in Curtobacterium pusillum strains.

1981 • 74 citations

Kijanimicin. 2. Structure and absolute stereochemistry of kijanimicin

1981 • 74 citations

Kijanimicin. 1. Structures of the individual sugar components

1981 • 73 citations

Kalafungin. II. Chemical transformations and the absolute configuration.

1976 • 72 citations

Stereochemistry of the dTDP-glucose oxidoreductase reaction.

1977 • 72 citations

KALAFUNGIN, A NEW BROAD SPECTRUM ANTIBIOTIC

1968 • 70 citations

Stoffwechselprodukte von Actinomyceten. 9. Mitteilung. Granaticin

1957 • 68 citations

Stoffwechselprodukte von Mikroorganismen. 107. Mitteilung [1]. Die Struktur des Chlorothricins, eines neuartigen Makrolid-Antibioticums

1972 • 67 citations

A genetic approach to the biosynthesis of the Rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit.

1981 • 67 citations

The structure of manumycin. I. Characterization, structure elucidation and biological activity.

1987 • 67 citations

Studies on the biosynthesis of the .ALPHA.-glucosidase inhibitor acarbose. Valienamine, a m-C7N unit not derived from the shikimate pathway.

1987 • 67 citations

Bestimmung der Isotopenverteilung in markierten Verbindungen

1967 • 64 citations

The formation of ω-cyclohexyl-fatty acids from shikimate in an acidophilic thermophilic bacillus. A new biosynthetic pathway

1972 • 64 citations

3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis

1980 • 62 citations

Biosynthesis of the antibiotic granaticin

1979 • 62 citations

Biosynthesis of actinorhodin. Determination of the point of dimerization

1981 • 60 citations

Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.

1982 • 59 citations

The structures of griseusins A and B, new isochromanquinone antibiotics

1976 • 58 citations

Carbon-13 as a Label in Biosynthetic Studies

1974 • 58 citations

Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.

1980 • 57 citations

Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II.

1982 • 57 citations

Direct evidence from multiple carbon-13-labeling and homonuclear decoupling for the labeling pattern by glucose of the m-aminobenzoyl (C7N) unit of pactamycin

1981 • 56 citations

Stereochemistry of methylation in thienamycin biosynthesis: example of a methyl transfer from methionine with retention of configuration

1986 • 56 citations

Effects of pH and Temperature on the Fatty Acid Composition of Bacillus acidocaldarius

1974 • 56 citations

D-Glucosamine and L-citrulline, precursors in mitomycin biosynthesis by Streptomyces verticillatus

1974 • 56 citations

Stoffwechselprodukte von Mikroorganismen. 66.Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 1. Teil: Spektroskopische Eigenschaften und chemischer Abbau

1968 • 55 citations

The Chemistry of Actinospectacin. IV. The Determination of the Structure of Actinospectacin

1963 • 54 citations

Biosynthesis of the antitumor antibiotic pactamycin. A methionine-derived ethyl group and a C7N unit

1978 • 52 citations

The Mode of Action of Nosiheptide (Multhiomycin) and the Mechanism of Resistance in the Producing Organism

1981 • 50 citations

Utilization of carbon-13 carbon-13 coupling in structural and biosynthetic studies. Alternate double labeling method

1973 • 50 citations

Thiostrepton. Degradation Products and Structural Features

1964 • 50 citations

A new antibiotic, asukamycin, produced by Streptomyces.

1976 • 50 citations

Actinorhodin, ein roter Farbstoff aus Actinomyceten

1947 • 49 citations

The structure of tetronolide, the aglycone of antitumor antibiotic tetrocarcin

1980 • 49 citations

L-155,175: A new antiparasitic macrolide fermentation, isolation and structure.

1985 • 48 citations

Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

1988 • 48 citations

Stoffwechselprodukte von Mikroorganismen, 129¹⁾ Isolierung und Konstitution der Isochromanchinon‐Antibiotica β‐ und γ‐Naphthocyclinon

1974 • 47 citations

Nanomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanomycin C, and biological activities of nanaomycin derivatives.

1975 • 47 citations

Radiotracer Techniques and Applications

1978 • 47 citations

Über Actinomycetenfarbstoffe, VIII. Die Konstitution des Actinorhodins

1966 • 46 citations

Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics.

1982 • 45 citations

Naphthomycin, a novel ansa macrocyclic antimetabolite. Proton NMR spectra and structure elucidation using lanthanide shift reagent.

1975 • 45 citations

Structure of nanaomycin E, a new nanaomycin.

1979 • 45 citations

Stoffwechselprodukte von Mikroorganismen. 108. Mitteilung. Kristallstrukturanalyse des Chlorothricolid‐methylesters

1972 • 44 citations

Naphto- and anthraquinones of Streptomyces thermoviolaceusWR-141. Structures and model syntheses

1977 • 44 citations

Some new n.m.r. methods for tracing the fate of hydrogen in biosynthesis

1979 • 43 citations

Interaction of antibiotics with membranes: Chlorothricin

1972 • 43 citations

Studies on mycotrienin antibiotics, a novel class of ansamycins. III. The isolation, characterization and structures of mycotrienols I and II.

1982 • 43 citations

Biological Mechanisms Involved in the Formation of Deoxy Sugars: Enzymatic Hydrogen Mediation

1973 • 40 citations

Biosynthesis of the Ansamycin Antibiotic Ansatrienin (Mycotrienin) by Streptomyces collinus

1987 • 40 citations

Biosynthetic studies on validamycins: a C2 + C2 + C3 pathway to an aliphatic C7N unit

1987 • 39 citations

IDENTITY OF THE ANTITUMOR ANTIBIOTIC LITMOMYCIN WITH GRANATICIN A

1975 • 39 citations

Further studies on the biosynthesis of chlorothricin.

1986 • 39 citations

Über Actinomycetenfarbstoffe, IX¹⁾ Konformation und absolute Konfiguration des Actinorhodins

1969 • 38 citations

Structure of the Antibiotic Moenomycin A

1981 • 38 citations

Die konstitution der fungistatischen ansamycin-antibiotica ansatrienin A und B

1982 • 38 citations

Biosynthesis of the Cinchona alkaloids. II. Incorporation of tryptophan-1-15N,2-14C and geraniol-3-14C into quinine

1969 • 38 citations

Ansamycin biogenesis: Incorporation of [1‐¹³C]glucose and [1‐¹³C]glycerate into the chromophore of rifamycin S

1974 • 37 citations

Stoffwechselprodukte von Mikroorganismen. Granaticin B

1966 • 35 citations

Rifamycin Biosynthesis: Further Studies on Origin of the Ansa Chain and Chromophore

1974 • 35 citations

Stoffwechselprodukte von Mikroorganismen, 128¹⁾ Isolierung und Konstitution von α‐Naphthocyclinon

1974 • 35 citations

The structure of virustomycin A.

1983 • 34 citations

Hydrogen isotope effects in the cyclization of D-glucose 6-phosphate by myo-inositol-1-phosphate synthase.

1977 • 34 citations

Chiral Methyl Groups

1979 • 33 citations

Stereochemistry of indolmycin biosynthesis. Steric course of C- and N-methylation reactions

1980 • 33 citations

Selective Inhibition of Initiating Ribosomes by Spectinomycin

1974 • 33 citations

Total synthesis of (+)-aplasmomycin

1986 • 33 citations

Struktur des Antibioticums Moenomycin A

1981 • 32 citations

The structure of manumycin. III. Absolute configuration and conformational studies.

1987 • 32 citations

A superior pulse sequence for two-dimensional chemical shift correlation spectroscopy

1982 • 31 citations

The solution conformation of the peptide antibiotic thiostrepton. A 1H NMR study.

1983 • 31 citations

Stoffwechselprodukte von Mikroorganismen. 67. Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 2. Teil: Die Kristallstruktur des Tri‐O‐acetyl‐O‐jodacetyl‐granaticins

1968 • 30 citations

Structure of a boron‐free hydrolysis product from Boromycin

1974 • 30 citations

Biosynthesis of boromycin

1981 • 30 citations

OM-173,new nanaomycin-type antibiotics produced by a strain of streptomyces. Taxonomy,production,isolation and biological properties.

1983 • 29 citations

Biosynthesis of ansatrienin. Nonincorporation of shikimic acid into the mC7N unit and stereochemistry of its conversion to the cyclohexanecarboxylic acid moiety

1987 • 28 citations

Stoffwechselprodukte von Mikroorganismen

1969 • 28 citations

Further studies on the biosynthesis of the boron-containing antibiotic aplasmomycin

1987 • 28 citations

Über die Biogenese des Rifamycins S

1973 • 28 citations

Use of D-[13C6]glucose together with carbon-13-depleted glucose and homonuclear carbon-13 decoupling to identify the labeling pattern by this precursor of the "m-C7N" unit of geldanamycin

1982 • 28 citations

Hybrid antibiotics — the contribution of the new gene combinations

1987 • 28 citations

Biosynthesis of the macrolide antibiotic chlorothricin

1981 • 28 citations

Biosynthesis of the kinamycin antibiotics by Streptomyces murayamaensis. Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR spectroscopy

1986 • 27 citations

Berninamycin biosynthesis. 1. Origin of the dehydroalanine residues

1979 • 27 citations

Spectinomycin biosynthesis studied by carbon magnetic resonance spectroscopy

1976 • 27 citations

ChemInform Abstract: BIOSYNTHESIS OF ACTINORHODIN. DETERMINATION OF THE POINT OF DIMERIZATION

1981 • 26 citations

Ansatrienin A2 and A3: Minor components of the ansamycin complex produced by Streptomyces collinus.

1983 • 26 citations

Correction. Biosynthesis of the Kinamycin Antibiotics by Strepomyces murayamaensis. Determination of the Origin of Carbon, Hydrogen, and Oxygen Atoms by ¹³C NMR Spectroscopy

1987 • 26 citations

Recent Biosynthetic Studies on Antibiotics

1980 • 26 citations

13C NMR study of thiostrepton and thiopeptin components.

1983 • 26 citations

Isolation and structural elucidation of naphthomycins B and C.

1983 • 26 citations

Neue Isochromanchinon‐Antibiotica der Naphthocyclinon‐Reihe

1983 • 25 citations

Studies on the Biosynthesis of Mitomycin C by Streptomyces verticillatus

1971 • 25 citations

Biosynthesis of the boron-containing antibiotic aplasmomycin. Nuclear magnetic resonance analysis of aplasmomycin and desboroaplasmomycin.

1980 • 25 citations

Biosynthesis of the boron-containing macrolide antibiotic aplasmomycin by Streptomyces griseus

1981 • 24 citations

The Use of Recombinant DNA Techniques to Study Tylosin Biosynthesis and Resistance in Streptomyces fradiae

1986 • 24 citations

Biosynthesis of the boron-containing macrodiolide antibiotic aplasmomycin

1979 • 24 citations

Bioconversion and biosynthesis of nanaomycins using cerulenin, a specific inhibitor of fatty acid and polyketide biosyntheses.

1980 • 24 citations

Die Struktur des γ-Naphthocyclinons

1983 • 24 citations

Radiotracer techniques and applications

1977 • 24 citations

[Experience of amikacin intravenous drip infusion (author's transl)].

1980 • 23 citations

Biosynthesis of the macrolide antibiotic chlorothricin: basic building blocks

1978 • 23 citations

Studies on the biosynthesis of the meta-C7N unit in the antibiotics manumycin and asukamycin

1988 • 22 citations

DEHYDROALANINE RESIDUES IN THIOSTREPTON

1970 • 22 citations

Bestimmung der Verknüpfung dimerer Isochromanchinone durch Diazomethan‐Abbau

1983 • 22 citations

Biosynthesis of Nanaomycin: Syntheses of Nanaomycin E from Nanaomycin A and of Nanaomycin B from Nanaomycin E in a Cell-Free System

1981 • 21 citations

Biosynthetic relationships in the naphthocyclinone series of isochromane quinone antibiotics

1982 • 21 citations

Proton transfer reactions of methylglyoxal synthase

1977 • 20 citations

Biosynthesis of .alpha.-naphthocyclinone

1978 • 20 citations

Biosynthesis of riboflavin. Analysis of biosynthetically carbon-13-labeled riboflavin by double-quantum and two-dimensional NMR

1983 • 20 citations

Identity of multhiomycin with nosiheptide.

1978 • 20 citations

Stoffwechselprodukte von Mikroorganismen. 84. Mitteilung [1]. Synthese des 5‐Chlor‐6‐methyl‐salicylsäure‐methyläthers, eines Abbauproduktes des Chlorothricins

1970 • 19 citations

Biosynthetic studies using ¹⁸O isotope shifts in ¹³C nuclear magnetic resonance

1982 • 19 citations

Structure of an antitumor antibiotic, reductiomycin

1981 • 19 citations

Nanaomycins production by a frenolicin B producing strain.

1986 • 19 citations

Peptide Antibiotics Biosynthesis and Functions

1982 • 18 citations

Biosynthesis of the antiobiotic reductiomycin

1986 • 18 citations

Anomeric and other substrate specificity studies with myo-inositol-1-P synthase.

1985 • 18 citations

Stereochemical aspects of the biosynthesis of spectinomycin

1980 • 18 citations

The stereospecificity of D-glucose-6-phosphate: 1L-myo-Inositol-1-phosphate cycloaldolase on the hydrogen atoms at C-6

1973 • 18 citations

Naphthomycin, an antimetabolite of vitamin K_1

1969 • 18 citations

Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

1987 • 17 citations

Specificity effects in the biosynthesis of fatty acids in Bacillus acidocaldarius

1974 • 17 citations

NMR method to detect stereospecific deuterium labeling at diastereotopic methylene hydrogens: selective proton, carbon-13 heteronuclear shift correlation

1985 • 17 citations

Reductiomycin,a new antibiotic I. Taxonomy,fermentation,isolation,characterization and biological activities.

1981 • 17 citations

Metabolites of microorganisms. 229. Absolute configuration of naphthomycin A determined by X-ray analysis and chemical degradation.

1984 • 17 citations

Degradation studies of naphthomycin.

1979 • 16 citations

Senacarcin A, a new antitumor antibiotic produced by Streptomyces endus subsp. aureus.

1982 • 16 citations

The structures of myocotrienins I. and II, a novel class of ansamycin antibiotic.

1982 • 16 citations

The ansamycin antibiotic actamycin. II. Determination of the structure using carbon-13 biosynthetic labelling

1981 • 15 citations

Biological methods for studying the biosynthesis of natural products

1986 • 14 citations

Biosynthesis of the antibiotic 2,5-dihydrophenylalanine by Streptomyces arenae

1978 • 14 citations

Stoffwechselprodukte von Mikroorganismen 147. Mitteilung Über eine unerwartete Umwandlung in der Chlorothricin‐Reihe

1975 • 14 citations

A NMR analysis of boromycin sodium complex and sodium desvalinoboromycinate

1986 • 13 citations

Biosynthesis of nanaomycin. III. Nanaomycin A formation from nanaomycin D by nanaomycin D reductase via a hydroquinone.

1982 • 13 citations

Biosynthesis of Nanaomycin. II. Purification and Properties of Nanaomycin D Reductase Involved in the Formation of Nanaomycin A from Nanaomycin D1

1981 • 13 citations

Stable Isotopes in Biosynthetic Studies

1975 • 13 citations

Mode of Action of the Macrolide‐Type Antibiotic, Chlorothricin

1975 • 12 citations

Structure of antitumor alkaloid AM-6201.

1981 • 12 citations

¹³C‐NMR. Analysis of Dihydrogranaticin Methyl Ester. A case of mixed biogenesis

1979 • 11 citations

Development of triple-quantum “INADEQUATE” for biosynthetic studies

1987 • 11 citations

Biosynthesis of ketomycin.

1984 • 11 citations

Methodology

1972 • 11 citations

Naphthochinon-Antibiotica ausStreptomyces lateritius. I. Fermentation, Isolierung und Charakterisierung der Granatomycine A, C und D

1980 • 10 citations

Further Studies on the Biosynthesis of Granaticin

1986 • 10 citations

Biosynthesis of the Antibiotic Grananticin: Assignment of the Carbon-13 Magnetic Resonance Spectrum

1979 • 10 citations

Biosynthesis of manumycin: Origin of the polyene chains.

1988 • 10 citations

N.M.R. with stable isotopes in biosynthetic studies

1976 • 9 citations

Stable isotopes in biosynthetic studies

1973 • 8 citations

Biosynthesis of the Antibiotic Chlorothricin: Assignment of the Carbon-13 Magnetic Resonance Spectrum

1979 • 7 citations

Curtobacterium pusilumによるD‐〔6,6‐2H2〕‐グルコースから11‐シクロヘキシルウンデカノイン酸への立体特異的な重水素の取込

1986 • 7 citations

Isolation and structure of nanaomycin D, an enantiomer of the antibiotic kalafungin.

1976 • 6 citations

Stoffwechselprodukte von mikroorganismen 201. Mitteilung: Ansatrienin A und B, fungistatische antibiotika aus Streptomyces collinus

1981 • 6 citations

Macrolide Antibiotics : Chemisty, Biology and Practice, 大村 智 編, B5判, 365頁, 89.5ドル, (Academic Press)

1985 • 6 citations

Naphthochinon‐Antibiotica aus Streptomyces lateritius. I. Fermentation, Isolierung und Charakterisierung der Granatomycine A, C und D

1980 • 6 citations

Atmospheric Clear Air Turbulence

1966 • 6 citations