The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis

EFFECT OF TEMPERATURE ON THE COMPOSITION OF FATTY ACIDS IN ESCHERICHIA COLI

1962 • 735 citations

Physical properties of membrane lipids: biological relevance and regulation

1975 • 351 citations

Metabolism and function of the membrane phospholipids of Escherichia coli

1972 • 329 citations

Inhibition of fatty acid synthetases by the antibiotic cerulenin

1972 • 273 citations

Inhibition of fatty acid synthesis by the antibiotic cerulenin

1973 • 241 citations

Temperature Control of Phospholipid Biosynthesis in Escherichia coli

1971 • 227 citations

Studies in relation to Biosynthesis. I. Some possible routes to derivatives of Orcinol and Phloroglucinol

1953 • 220 citations

Fatty acid mutant of E. coli lacking a beta-hydroxydecanoyl thioester dehydrase.

1967 • 170 citations

Enzymic Synthesis of an Aromatic Ring from Acetate Units. Partial Purification and Some Properties of Flavanone Synthase from Cell-Suspension Cultures of Petroselinum hortense

1975 • 167 citations

Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

1972 • 154 citations

Detection of an inducible membrane protein associated with R-factor-mediated tetracycline resistance

1974 • 143 citations

Acetate Utilization and Macromolecular Synthesis During Sporulation of Yeast

1969 • 131 citations

Die biochemischen Grundlagen der „Polyacetat‐Regel”︁

1961 • 124 citations

Regulation of Phospholipid Synthesis in Escherichia coli by Guanosine Tetraphosphate

1973 • 103 citations

The Action Mechanism of Cerulenin

1972 • 100 citations

Fat metabolism in higher plants

1974 • 99 citations

Biogenesis of membrane lipids: mutants of Escherichia coli with temperature-sensitive phosphatidylserine decarboxylase.

1975 • 96 citations

Inhibition of Lipid Synthesis in Escherichia coli Cells by the Antibiotic Cerulenin

1973 • 90 citations

Stringent Control of Fatty Acid Synthesis in Escherichia coli

1973 • 90 citations

Thermal regulation of the membrane lipid composition of Escherichia coli. Evidence for the direct control of fatty acid synthesis.

1975 • 84 citations

A Saccharomyces cerevisiae Mutant Defective in Saturated Fatty Acid Biosynthesis

1970 • 82 citations

The Antibacterial Activity of 3-Decynoyl-N-acetylcysteamine

1968 • 80 citations

Acyl Carrier Protein

1972 • 79 citations

On the enzymatic synthesis of unsaturated fatty acids in Escherichia coli.

1967 • 75 citations

Fatty acid synthetases from Euglena gracilis

1971 • 75 citations

Evidence that acyl coenzyme A synthetase activity is required for repression of yeast acetyl coenzyme A carboxylase by exogenous fatty acids.

1976 • 72 citations

Temperature-Sensitive Mutants of Escherichia coli Requiring Saturated and Unsaturated Fatty Acids for Growth: Isolation and Properties

1972 • 70 citations

Changes in the Lipid Composition and Fine Structure ofSaccharomyces cerevisiaeDuring Ascus Formation

1973 • 70 citations

Acyl Carrier Protein

1969 • 65 citations

THE METABOLISM OF YEAST SPORULATION: IV. CYTOLOGICAL AND PHYSIOLOGICAL CHANGES IN SPORULATING CELLS

1962 • 62 citations

Mutants of Escherichia coli with Temperature-sensitive Malonyl Coenzyme A-Acyl Carrier Protein Transacylase

1974 • 59 citations

The Biosynthesis of β-Hydroxy-β-methylglutaryl Coenzyme A in Yeast

1966 • 56 citations

STUDIES ON CANDICIDIN BIOGENESIS

1972 • 54 citations

Biosynthetic studies using carbon-13 enriched precursors on the 16-membered macrolide antibiotic leucomycin A3

1975 • 53 citations

REVISED STRUCTURE OF CERULENIN

1974 • 53 citations

Substitution of cellular fatty acids in yeast cells by the antibiotic cerulenin and exogenous fatty acids

1975 • 52 citations

Inhibition of Sporulation by Cerulenin and Its Reversion by Exogenous Fatty Acids in Saccharomyces cerevisiae

1976 • 50 citations

Synthesis of Unsaturated Fatty Acids and the Lesion in fab B Mutants

1973 • 50 citations

Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin

1975 • 48 citations

INHIBITION OF STEROL AND FATTY ACID BIOSYNTHESES BY CERULENIN IN CELL-FREE SYSTEMS OF YEAST

1972 • 48 citations

Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast

1974 • 46 citations

Stringent and Relaxed Control of Phospholipid Metabolism in Escherichia coli

1972 • 42 citations

PRODUCTION OF AMPHOTERICIN B-14C BY STREPTOMYCES NODOSUS FERMENTATION, AND PREPARATION OF THE AMPHOTERICIN B-14C-METHYL-ESTER

1974 • 42 citations

Inhibition of 6-Methylsalicylic Acid Synthesis by the Antibiotic Cerulenin

1975 • 41 citations

Induction of Staphylococcus aureus Lactose Permease in the Absence of Glycerolipid Synthesis

1971 • 38 citations

Helvolic Acid, an Antibiotic produced by Aspergillus fumigatus, mut. helvola Yuill.

1943 • 37 citations

rel Gene Control of Lipid Synthesis in Escherichia coli

1974 • 36 citations

Regulation of the Fatty Acid Composition of the Membrane Phospholipids of Escherichia coli

1974 • 35 citations

Induction of Citrate Transport inBacillus subtilisDuring the Absence of Phospholipid Synthesis

1971 • 34 citations

Lipid Synthesis During Sporulation of Saccharomyces cerevisiae

1973 • 33 citations

STUDIES ON CERULENIN. IV. BIOLOGICAL CHARACTERISTICS OF CERULENIN.

1964 • 33 citations

Factors Controlling the Sporulation of Yeasts II. The Sporulation Phase

1967 • 32 citations

The Structure of Helvolic Acid

1964 • 32 citations

Inhibition of the Biosynthesis of Leucomycin, a Macrolide Antibiotic, by Cerulenin

1977 • 32 citations

Acyl Carrier Protein

1970 • 31 citations

THE BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC LUCENSOMYCIN

1969 • 28 citations

Structure of prumycin

1974 • 27 citations

Studies on cerulenin. V. Structure of cerulenin.

1967 • 27 citations

Nystatin. Part VI. Chemistry and partial structure of the antibiotic

1964 • 27 citations

Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin.

1967 • 27 citations

Inhibition of the biosynthesis of leucomycin,a macrolide antibiotic,by cerulenin(Short communication)

1974 • 27 citations

Inhibition of De Novo Fatty Acid Synthesis by the Antibiotic Cerulenin in Bacillus subtilis : Effects on Citrate-Mg ²⁺ Transport and Synthesis of Macromolecules

1975 • 26 citations

Relationship Between the Structures of Fatty Acid Amide Derivatives and Their Antimicrobial Activities

1974 • 25 citations

The structure of cephalonic acid, a pentaprenyl terpenoid

1967 • 24 citations

RC gene control in Escherichia coli is not restricted to RNA synthesis

1970 • 20 citations

Studies on Cerulenin. VI. Some Spectroscopic Features of Cerulenin

1969 • 19 citations

Studies on Microbial Products. I. 7-Desacetoxyhelvolic Acid and Helvolinic Acid

1966 • 19 citations

Microbiological transformations of fusidane-type antibiotics a correlation between fusidic acid and helvolic acid

1968 • 19 citations

STUDIES ON CERULENIN. I. STUDIES ON CERULENIN PRODUCING STRAIN.

1963 • 18 citations

Chapter 2 Regulation of Sporulation in Yeast

1972 • 15 citations

Induction of Tetracycline Resistance in Staphylococcus aureus in the Absence of Lipid Synthesis

1975 • 13 citations

FACTORS INFLUENCING DEATH OF BIOTIN-DEFICIENT YEAST CELLS

1971 • 12 citations

Preparation of 13C- and 3H-labeled cerulenin and biosynthesis with 13C-NMR.

1975 • 11 citations

Inhibition by cerulenin of lipid synthesis in Crambe abyssinica tissues

1974 • 10 citations

Antigen Specific for Bacteria Resistant to Tetracycline

1974 • 9 citations

Biogenesis of cycloheximide and of related compounds.

1966 • 7 citations

Insertion of a minor protein into the outer membrane of Escherichia coli during inhibition of lipid synthesis

1975 • 6 citations

STUDIES ON CERULENIN. II. BIOLOGICAL ASSAY AND FERMENTATION OF CERULENIN.

1963 • 6 citations