Transforming Growth Factor β Inhibits the Phosphorylation of pRB at Multiple Serine/Threonine Sites and Differentially Regulates the Formation of pRB Family–E2F Complexes in Human Myeloid Leukemia Cells

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Purification and initial characterization of a type beta transforming growth factor from human placenta.

1983 • 409 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor.

1986 • 317 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

The Transcription Factor E2F-1 Is a Downstream Target of RB Action

1995 • 190 citations

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

1993 • 179 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Transcriptional control by E2F

1995 • 147 citations

Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.

1993 • 88 citations

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor β through E2F binding sites

1997 • 58 citations

An E2F dominant negative mutant blocks E1A induced cell cycle progression.

1994 • 55 citations

p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by α-Interferon

1998 • 52 citations

Transforming growth factor β inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795

1999 • 20 citations

E2F-3 accumulation is regulated by polypeptide stability

1998 • 19 citations

Regulation and Activity of the Retinoblastoma Protein Family in Growth Factor-Deprived and TGFβ-Treated Keratinocytes

1996 • 9 citations