Apoptosis in atherosclerosis: beneficial or detrimental?

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Death in Embryonic Systems

1966 • 943 citations

Stability and Instability: Two Faces of Coronary Atherosclerosis

1996 • 910 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Lewis A. Conner Memorial Lecture

1997 • 754 citations

Fas-Induced Caspase Denitrosylation

1999 • 742 citations

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

1995 • 700 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

1999 • 619 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Tissue Factor Modulates the Thrombogenicity of Human Atherosclerotic Plaques

1997 • 612 citations

Lipid Lowering by Diet Reduces Matrix Metalloproteinase Activity and Increases Collagen Content of Rabbit Atheroma

1998 • 565 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

Macrophages and atherosclerotic plaque stability

1996 • 474 citations

Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

1997 • 468 citations

Apoptosis and Related Proteins in Different Stages of Human Atherosclerotic Plaques

1998 • 432 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability.

1996 • 420 citations

Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite.

1996 • 410 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

1997 • 373 citations

Angiotensin II Induces Apoptosis of Human Endothelial Cells

1997 • 363 citations

Fibrous cap formation or destruction — the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation

1999 • 350 citations

Recognition and phagocytosis of cells undergoing apoptosis

1997 • 330 citations

Significance of Myocytes With Positive DNA In Situ Nick End-Labeling (TUNEL) in Hearts With Dilated Cardiomyopathy

1999 • 321 citations

Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery.

1984 • 320 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

The other side of scavenger receptors: pattern recognition for host defense

1997 • 312 citations

Atherosclerotic plaque rupture – pathologic basis of plaque stability and instability

1999 • 311 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

ADP-Ribosylation of Proteins

1987 • 288 citations

Apoptosis participates in cellularity regulation during rat aortic intimal thickening.

1995 • 285 citations

The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo

1999 • 278 citations

Collagen synthesis in atherosclerosis: too much and not enough

1999 • 274 citations

Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture

1999 • 273 citations

Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease

1998 • 273 citations

Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells

1997 • 270 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

Expression of Extracellular SOD and iNOS in Macrophages and Smooth Muscle Cells in Human and Rabbit Atherosclerotic Lesions

1998 • 241 citations

Apoptosis in the Atherosclerotic Plaque

1998 • 238 citations

RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis.

1998 • 227 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-gamma, heparin, and cyclic nucleotide analogues and induces apoptosis.

1994 • 200 citations

Apoptosis (Programmed Cell Death) in Arteries of the Neonatal Lamb

1995 • 200 citations

Mechanisms of plaque rupture mechanical and biologic interactions

1999 • 189 citations

Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?

1998 • 182 citations

Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II.

1994 • 177 citations

Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques

1999 • 177 citations

Differentiation, Dedifferentiation, and Apoptosis of Smooth Muscle Cells During the Development of the Human Ductus Arteriosus

1997 • 172 citations

FOAM CELL APOPTOSIS AND THE DEVELOPMENT OF THE LIPID CORE OF HUMAN ATHEROSCLEROSIS

1996 • 169 citations

Cell Composition, Replication, and Apoptosis in Atherosclerotic Plaques After 6 Months of Cholesterol Withdrawal

1998 • 168 citations

Regulation of endothelial monocyte-activating polypeptide II release by apoptosis

1998 • 156 citations

Collagen synthesis by cultured rabbit aortic smooth-muscle cells. Alteration with phenotype

1990 • 152 citations

Regression of Atherosclerosis

1999 • 152 citations

Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein.

1994 • 151 citations

Human transplant coronary artery disease: pathological evidence for Fas-mediated apoptotic cytotoxicity in allograft arteriopathy.

1996 • 149 citations

Apoptosis is associated with increased cell surface tissue factor procoagulant activity.

1996 • 143 citations

Thrombin Generation by Apoptotic Vascular Smooth Muscle Cells

1997 • 142 citations

The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions

1997 • 140 citations

Apoptosis

1999 • 125 citations

Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques

1999 • 115 citations

Endothelial-monocyte-activating polypeptide II

1996 • 111 citations

Distribution of cell replication and apoptosis in atherosclerotic plaques of cholesterol-fed rabbits

1996 • 111 citations

Atherosclerosis in APOE*3-Leiden Transgenic Mice

1999 • 101 citations

Proliferation, migration, matrix turnover, and death of smooth muscle cells in native coronary and vein graft atherosclerosis

1996 • 100 citations

Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species

1998 • 97 citations

Topographical Association Between the Cyclin-Dependent Kinases Inhibitor P21, p53 Accumulation, and Cellular Proliferation in Human Atherosclerotic Tissue

1997 • 96 citations

Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits

1997 • 92 citations

Nitric oxide inhibits APO-1/Fas-mediated cell death.

1998 • 90 citations

Colocalization of CPP-32 With Apoptotic Cells in Human Atherosclerotic Plaques

1997 • 90 citations

Apoptosis in Restenosis Versus Stable-Angina Atherosclerosis

1998 • 86 citations

Induction of apoptosis and of interleukin‐1β secretion by 7β‐hydroxycholesterol and 7‐ketocholesterol: partial inhibition by Bcl‐2 overexpression

1997 • 83 citations

Luminal Foam Cell Accumulation Is Associated With Smooth Muscle Cell Death in the Intimal Thickening of Human Saphenous Vein Grafts

1996 • 83 citations

Apoptosis in atherogenesis: implications for plaque destabilization.

1998 • 80 citations

Atherosclerotic Plaque Rupture

2016 • 77 citations

Nitric oxide protects endothelial cells from tumor necrosis factor‐α‐mediated cytotoxicity: possible involvement of cyclic GMP

1997 • 69 citations

Cerebral atherosclerosis in swine: Role of necrosis in progression of diet-induced lesions from proliferative to atheromatous stage

1968 • 49 citations

Cerebral atherosclerosis. Intimal proliferation and atherosclerosis in the cerebral arteries.

1975 • 49 citations

In situ nick translation of metaphase chromosomes with biotin-labeled d-UTP

1985 • 37 citations

In situ nick translation of human and mouse chromosomes detected with a biotinylated nucleotide

1985 • 34 citations

Cell Proliferation and Collagen Synthesis Are Two Independent Events in Human Atherosclerotic Plaques

1994 • 31 citations

Macrophage dysfunction following the phagocytosis of IgG-coated erythrocytes: production of lipid peroxidation products

1996 • 28 citations

THE P53 TUMOR-SUPPRESSOR GENE IS OVEREXPRESSED BUT NOT MUTATED IN HUMAN ATHEROSCLEROTIC TISSUE

1995 • 19 citations

Atherosclerotic Plaques

2006 • 2 citations