The effect of liposome (phospholipid vesicle) entrapment of actinomycin D and methotrexate on the in vivo treatment of sensitive and resistant solid murine tumours

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Liposomes as drug carriers

1977 • 664 citations

Preparation and Use of Liposomes as Models of Biological Membranes

1974 • 567 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Drug entrapment in liposomes

1973 • 405 citations

Targeting of drugs

1977 • 396 citations

Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.

1970 • 285 citations

Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.

1978 • 268 citations

Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins

1978 • 248 citations

Properties and Biological Effects of Liposomes and their uses in Pharmacology and Toxicology

1978 • 167 citations

Pharmacokinetics of liposome-encapsulated anti-tumor drugs

1978 • 162 citations

Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation

1958 • 95 citations

Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia.

1977 • 87 citations

Inhibition of tumor cell growth in vitro and in vivo by 1-beta-D-arabinofuranosylcytosine entrapped within phospholipid vesicles.

1976 • 81 citations

Use of lipid vesicles as carriers to introduce actinomycin D into resistant tumor cells.

1976 • 79 citations

Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.

1977 • 76 citations

Differential distribution of liposome-entrapped [3H]methotrexate and labelled lipids after intravenous injection in a primate

1976 • 70 citations

Role of liposome type and route of administration in the antitumor activity of liposome-entrapped 1-beta-D-arabinofuranosylcytosine against mouse L1210 leukemia.

1979 • 68 citations

Liposome-Encapsulated Actinomycin D: Potential in Cancer Chemotherapy

1974 • 67 citations

The mechanism of the adjuvant effect of dextran sulphate.

1974 • 65 citations

Possible tumor localization of Tc-99m-labeled liposomes: effects of lipid composition, charge, and liposome size.

1978 • 61 citations

Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors.

1978 • 59 citations

EFFECTS OF ENTRAPMENT IN LIPOSOMES ON THE DISTRIBUTION, DEGRADATION AND EFFECTIVENESS OF METHOTREXATE IN VIVO

1978 • 41 citations

Interactions of drugs with lipid membranes

1979 • 36 citations

Treatment of tumour bearing mice with liponsome-entrapped actinomycin D prolongs their survival.

1975 • 33 citations

Enhancement of anti‐tumor activity of 1‐β‐d‐arabinofuranosylcytosine by encapsulation in liposomes

1977 • 33 citations

MECHANISMS OF REDUCTION OF ANTITUMOR DRUG TOXICITY BY LIPOSOME ENCAPSULATION *

1978 • 30 citations

Actinomycin D: effects on Ridgway osteogenic sarcoma in mice.

1966 • 28 citations

Lipid vesicle interaction with EMT-6 tumor cells and effect on subsequent cell growth

1976 • 23 citations

Effects of methotrexate on cellular metabolism: some critical elements in the drug-cell interaction.

1977 • 23 citations

Studies on the disposition of actinomycin D-3H in virus-infected and tumor-bearing mice.

1966 • 19 citations

The role of drug delivery systems in cancer chemotherapy.

1976 • 19 citations

Liposomal potentiation of the antitumor activity of alkylating drugs.

1976 • 15 citations

Enhancement of the cancer chemotherapeutic effect of the cell cycle phase specific agents methotrexate and cytosine arabinoside when given as a water-oil-water emulsion

1974 • 14 citations

The fate of liposome-entrapped actinomycin D in vivo and its therapeutic effect in a solid murine tumour

1980 • 10 citations

Comparison of the cytotoxicity of methotrexate and aminopterin on methotrexate resistant murine lymphoma cells in vitro

1978 • 3 citations

GENERAL MECHANISMS OF CLINICAL RESISTANCE TO CANCER CHEMOTHERAPY

1975 • 1 citations