Liposomes as drug carriers

Diffusion of univalent ions across the lamellae of swollen phospholipids

1965 • 4,347 citations

Catalysis in micellar and macromolecular systems

1978 • 1,285 citations

Catalysis in micellar and macromolecular systems

2012 • 1,035 citations

Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol

1973 • 986 citations

Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction

1968 • 891 citations

Liposomes as immunological adjuvants

1974 • 659 citations

Lipid composition and permeability of liposomes

1968 • 605 citations

The Carrier Potential of Liposomes in Biology and Medicine

1976 • 576 citations

Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles

1975 • 540 citations

Dynamics of lipids in membranes: Heterogeneity and the role of cholesterol

1972 • 526 citations

The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs

1975 • 516 citations

Large volume liposomes by an ether vaporization method

1976 • 515 citations

Membrane fusion and molecular segregation in phospholipid vesicles

1974 • 445 citations

Kupffer Cells and Other Liver Sinusoidal Cells

1978 • 434 citations

Physiology and Physiopathology of the Reticuloendothelial System

1970 • 412 citations

Drug entrapment in liposomes

1973 • 405 citations

DRUG-CARRIER POTENTIAL OF LIPOSOMES IN CANCER CHEMOTHERAPY

1974 • 384 citations

New aspects of liposomes

1976 • 368 citations

Fate of Protein‐Containing Liposomes Injected into Rats

1972 • 339 citations

Permeability properties of phospholipid membranes: Effect of cholesterol and temperature

1972 • 336 citations

Studies on membrane fusion. II. Induction of fusion in pure phospholipid membranes by calcium ions and other divalent metals

1976 • 316 citations

Enzyme entrapment in liposomes

1971 • 313 citations

Homing of liposomes to target cells

1975 • 291 citations

The effect of chain length and lipid phase transitions on the selective permeability properties of liposomes

1975 • 290 citations

Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated drugs

1978 • 285 citations

Theory of biomembrane phase transitions

1973 • 239 citations

Fusion of mammalian cells by unilamellar lipid vesicles: Influence of lipid surface charge, fluidity and cholesterol

1973 • 236 citations

Interactions and reactions in reversed micellar systems

1976 • 235 citations

FORMATION OF VIROSOMES FROM INFLUENZA SUBUNITS AND LIPOSOMES

1975 • 231 citations

Effect of the gel to liquid crystalline phase transition on the osmotic behaviour of phosphatidycholine liposomes

1976 • 214 citations

Control of the Rate of Hepatic Uptake and Catabolism of Liposome‐Entrapped Proteins Injected into Rats. Possible Therapeutic Applications

1974 • 207 citations

Oral administration of insulin by encapsulation within liposomes

1976 • 205 citations

Incorporation of Lysozyme into Liposomes

1970 • 196 citations

Solubilization by surface-active agents and its applications in chemistry and the biological sciences

1968 • 181 citations

Characteristics of sendai virus receptors in a model membrane

1974 • 173 citations

Studies on membrane fusion. I. Interactions of pure phospholipid membranes and the effect of myristic acid, lysolecithin, proteins and dimethylsulfoxide.

1976 • 170 citations

Permeability properties of liposomes prepared from dipalmitoyllecithin, dimyristoyllecithin, egg lecithin, rat liver lecithin and beef brain sphingomyelin

1974 • 166 citations

The formation and annealing of structural defects in lipid bilayer vesicles

1976 • 166 citations

Phospholipid vesicles (liposomes) as models for biological membranes: Their properties and interactions with cholesterol and proteins

1974 • 161 citations

Enzyme-containing Liposomes alleviate a Model for Storage Disease

1973 • 157 citations

Interaction of phospholipid vesicles with cultured mammalian cells. II. Studies of mechanism.

1975 • 154 citations

The in vivo Effects of Semipermeable Microcapsules containing L-Asparaginase on 6C3HED Lymphosarcoma

1971 • 146 citations

Interaction between lectin from Ricinus communis and liposomes containing gangliosides

1975 • 142 citations

The Macrophage

1973 • 140 citations

Studies on membrane fusion. 1. Interactions of pure phospholipid membranes and the effect of myristic acid, lysolecithin, proteins and dimethylsulfoxide

1976 • 135 citations

Cellular uptake of cyclic AMP captured within phospholipid vehicles and effect on cell-growth behaviour

1974 • 131 citations

Interaction of phospholipid vesicles with cells. Endocytosis and fusion as alternate mechanisms for the uptake of lipid-soluble and water-soluble molecules.

1975 • 129 citations

Intracellular Plutonium: Removal by Liposome-Encapsulated Chelating Agent

1973 • 129 citations

THE INTERACTION OF CATIONIC LIPOSOMES CONTAINING ENTRAPPED HORSERADISH PEROXIDASE WITH CELLS IN CULTURE

1974 • 128 citations

Interaction of phospholipid vesicles with cultured mammalian cells

1974 • 126 citations

Fragility of the permeability barrier of Escherichia coli

1972 • 118 citations

Entrapment of proteins in liposomes prevents allergic reactions in pre‐immunised mice

1974 • 117 citations

Tissue distribution of EDTA encapsulated within liposomes of varying surface properties

1975 • 116 citations

Introduction of purified hexosaminidase A into Tay-Sachs leukocytes by means of immunoglobulin-coated liposomes

1976 • 112 citations

Liposomes containing chelating agents. Cellular penetration and a possible mechanism of metal removal.

1975 • 108 citations

The effect of entrapment in liposomes on the in vivo distribution of [3H]methotrexate in a primate.

1976 • 102 citations

Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats

1974 • 98 citations

L-Asparaginase

1970 • 96 citations

Physiology and physiopathology of the reticuloendothelial system

1970 • 95 citations

The Adjuvant Properties of Liposomes

1976 • 90 citations

Inhibition of tumor cell growth in vitro and in vivo by 1-beta-D-arabinofuranosylcytosine entrapped within phospholipid vesicles.

1976 • 81 citations

Penetration of target areas in the rat by liposome‐associated bleomycin, glucose oxidase and insulin

1976 • 81 citations

Sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid

1976 • 77 citations

Lectin-receptor interactions in liposomes II. Interaction of wheat germ agglutinin with phospatidylcholine liposomes containing incorporated monosialoganglioside

1976 • 76 citations

Liposomes containing Antiviral Antibody can protect Cells from Virus Infection

1972 • 76 citations

Differential distribution of liposome-entrapped [3H]methotrexate and labelled lipids after intravenous injection in a primate

1976 • 70 citations

Interaction of Sindbis virus with liposomal model membranes

1975 • 70 citations

Fusion in phospholipid spherical membranes

1975 • 65 citations

Tumour Regression with Liposome-Entrapped Asparaginase: Some Immunological Advantages

1976 • 63 citations

Fusion in phospholipid spherical membranes

1976 • 60 citations

Liposomes as Carriers in vivo for Methotrexate

1975 • 59 citations

Lipid vesicle-cell interactions. II. Induction of cell fusion.

1976 • 57 citations

Interferon Induction by Poly(I):Poly(C) Enclosed in Phospholipid Particles

1974 • 50 citations

Chloride diffusion from liposomes

1974 • 48 citations

Drug-containing lipid vesicles render drug-resistant tumour cells sensitive to actinomycin D

1976 • 48 citations

Lectin-receptor interactions in liposomes

1975 • 44 citations

Timed‐Release Depot for Anticancer Agents

1975 • 43 citations

L‐Asparaginase entrapped in liposomes: Preparation and properties

1975 • 36 citations

Distribution of liposome-entrapped cations in tumor-bearing mice

1975 • 35 citations

The use of a liposomally entrapped enzyme in the treatment of an artificial storage condition

1976 • 32 citations

A comparison of negatively and positively charged liposomes containing entrapped polynosinic · polycytidylic acid for interferon induction in mice

1976 • 30 citations

α-Mannosidase in Zinc-Deficient Rats: Possibility of Liposomal Therapy in Mannosidosis

1974 • 30 citations

Intracellular Fate and Effect of Liposome-Entrapped Actinomycin D Injected into Rats

1974 • 28 citations

Penetration of Target Areas in the Rat by Liposome-Associated Agents Administered Parenterally and Intragastrically

1976 • 28 citations

Improved entrapment of drugs in modified liposomes

1976 • 25 citations

Encapsulation of 8-azaguanine in single multiple compartment liposomes

1976 • 22 citations

Prolonged Survival of Tumour-Bearing Mice Treated with Liposome-Entrapped Actinomycin D

1974 • 16 citations

The use of liposomes to facilitate uptake of external substances by living cells: possible therapeutic applications

1975 • 13 citations

Encapsulation of polyuridylic acid in phospholipid vesicles

1976 • 11 citations