Preparation and Use of Liposomes as Models of Biological Membranes

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Conduction of Heat in Solids

1959 • 19,468 citations

THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

1925 • 19,115 citations

Diffusion of univalent ions across the lamellae of swollen phospholipids

1965 • 4,347 citations

The Scattering of Light and Other Electromagnetic Radiation

1969 • 3,873 citations

thin layer chromatography

2021 • 2,762 citations

A simple, specific spray for the detection of phospholipids on thin-layer chromatograms

1964 • 2,146 citations

Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope

1964 • 1,653 citations

Conduction of heat in solids

1947 • 1,636 citations

Molecular motion in spin-labeled phospholipids and membranes

1971 • 1,591 citations

Phosphatidylcholine vesicles. Formation and physical characteristics

1969 • 1,522 citations

Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

1962 • 1,380 citations

Chromatographically homogeneous lecithin from egg phospholipids

1965 • 1,304 citations

Inside-outside transitions of phospholipids in vesicle membranes

1971 • 942 citations

Thin-layer chromatography, a laboratory handbook

1965 • 893 citations

THE STRUCTURE OF THE LIQUID-CRYSTALLINE PHASES OF LIPID-WATER SYSTEMS

1962 • 853 citations

Thermal analysis of lipids, proteins and biological membranes a review and summary of some recent studies

1969 • 813 citations

Lipid Chromatographic Analysis

1994 • 671 citations

The Origin of Life.

1938 • 637 citations

Thin layer chromatography a laboratory hand book

1969 • 623 citations

Formation and properties of thin‐walled phospholipid vesicles

1969 • 623 citations

Lipid composition of beef brain, beef liver, and the sea anemone: Two approaches to quantitative fractionation of complex lipid mixtures

1963 • 605 citations

Lipid composition and permeability of liposomes

1968 • 605 citations

Phospholipid model membranes. I. Structural characteristics of hydrated liquid crystals

1967 • 589 citations

The structure of the naturally occurring phosphoglycerides. 3. Action of moccasin-venom phospholipase A on ovolecithin and related substances

1957 • 552 citations

Membrane models with phospholipids

1968 • 536 citations

Osmotic properties and water permeability of phospholipid liquid crystals

1967 • 525 citations

A COLUMN CHROMATOGRAPHIC SEPARATION OF CLASSES OF PHOSPHOLIPIDES

1957 • 519 citations

Lipid chromatographic analysis

1968 • 508 citations

Physics and chemistry of spin labels

1970 • 468 citations

Phase equilibria and structure of dry and hydrated egg lecithin

1967 • 458 citations

An Apparatus for Microelectrophoresis of Small Particles

1958 • 430 citations

Phospholipid spherules (liposomes) as a model for biological membranes

1968 • 429 citations

Structure and Function in Biological Membranes

1965 • 427 citations

The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability

1969 • 411 citations

The detection of oxidation in liposome preparations

1970 • 408 citations

A Differential Scanning Calorimeter for Quantitative Differential Thermal Analysis.

1964 • 401 citations

The action of steroids and streptolysin S on the permeability of phospholipid structures to cations

1965 • 395 citations

Structure and Function of Biological Membranes

1971 • 384 citations

Structure of Oriented Lipid Bilayers

1971 • 374 citations

Quantitative analysis of phospholipids and phospholipid fatty acids from silica gel thin-layer chromatograms

1965 • 370 citations

Phospholipid model membranes. II. Permeability properties of hydrated liquid crystals

1967 • 359 citations

Biochemical problems of Lipids

1957 • 347 citations

Bilayer Structure in Membranes

1971 • 329 citations

Phospholipids. 3. On the chromatographic separation of glycerophospholipids

1955 • 323 citations

Lipid spin labels in lecithin multilayers. A study of motion along fatty acid chains

1971 • 323 citations

Reconstitution of Excitable Cell Membrane Structure in Vitro

1962 • 315 citations

Interaction of a Lytic Polypeptide, Melittin, with Lipid Membrane Systems

1969 • 314 citations

Enzyme entrapment in liposomes

1971 • 313 citations

The Analysis of a Temperature-Controlled Scanning Calorimeter.

1964 • 310 citations

WOUND HEALING AND COLLAGEN FORMATION

1965 • 298 citations

Improvements in the method of determining individual phospholipids in a complex mixture by successive chemical hydrolyses

1962 • 295 citations

The osmotic behavior and permeability to non-electrolytes of mitochondria

1955 • 293 citations

The measurement of 32P labelling of individual kephalins and lecithin in a small sample of tissue

1954 • 292 citations

Antibiotic Interaction with Model Membranes

1970 • 291 citations

Studies on the mechanism of action of local anesthetics with phospholipid model membranes

1972 • 286 citations

Phospholipids. 4. On the composition of hen's egg phospholipids

1957 • 281 citations

The structure of the naturally occurring phosphoglycerides. 4. Action of cabbage-leaf phospholipase D on ovolecithin and related substances

1958 • 265 citations

Lamellar and hexagonal lipid phases visualized by freeze-etching

1970 • 262 citations

Lipid Bilayers and Biomembranes

1972 • 261 citations

A SIMPLIFIED PURIFICATION OF LECITHIN

1951 • 258 citations

Determination of Equivalent Pore Radius for Human Red Cells by Osmotic Pressure Measurement

1960 • 251 citations

Nuclear Magnetic Resonance Spectroscopic Studies of the Interaction of Phospholipids with Cholesterol

1966 • 250 citations

Chloride‐Hydroxide Exchange across Mitochondrial, Erythrocyte and Artificial Lipid Membranes Mediated by Trialkyl‐ and Triphenyltin Compounds

1970 • 249 citations

Quantitative chromatographic fractionation of complex lipid mixtures: Brain lipids

1961 • 246 citations

BRAIN CEPHALIN, A MIXTURE OF PHOSPHATIDES. SEPARATION FROM IT OF PHOSPHATIDYL SERINE, PHOSPHATIDYL ETHANOLAMINE, AND A FRACTION CONTAINING AN INOSITOL PHOSPHATIDE

1942 • 244 citations

Recent progress in surface science

1964 • 235 citations

Single bilayer liposomes

1971 • 215 citations

Physical Studies of Phospholipids

1966 • 209 citations

Quantitative two-dimensional thin-layer chromatography of naturally occurring phospholipids

1964 • 209 citations

Cation Permeability of Phospholipid Model Membranes: Effect of Narcotics

1965 • 207 citations

Incorporation of Lysozyme into Liposomes

1970 • 196 citations

Electrokinetic requirements for the reaction between Cl. Perfringens α-toxin (phospholipase C) and phospholipid substrates

1962 • 190 citations

Biochemistry and methodology of lipids

1971 • 187 citations

Aqueous Dispersions of Phosphatidylserine

1964 • 186 citations

Interactions of Basic Proteins with Phospholipid Membranes

1971 • 185 citations

Ultrasonic Irradiation of Some Phospholipid Sols

1962 • 182 citations

Effects of temperature and cholesterol on the glucose permeability of liposomes prepared with natural and synthetic lecithins

1968 • 181 citations

Characterization of the plasma membrane of Mycoplasma laidlawii. VII. Phase transitions of membrane lipids

1970 • 179 citations

Phospholipid-protein interactions: Membrane permeability correlated with monolayer “penetration”

1971 • 177 citations

Mechanism of sonication of aqueous egg yolk lecithin dispersions and nature of the resultant particles

1972 • 173 citations

Potassium permeability of single compartment liposomes with and without valinomycin

1969 • 171 citations

Physical Structure and Behavior of Lipids and Lipid Enzymes

1963 • 170 citations

Antibody-complement interaction with lipid model membranes

1972 • 170 citations

A Correlation between Surface Charge and Coagulant Action of Phospholipids

1961 • 169 citations

Biochemical Problems of Lipids

1965 • 169 citations

High resolution proton relaxation studies of lecithins

1972 • 164 citations

Molecular Basis of Gouty Inflammation: Interaction of Monosodium Urate Crystals with Lysosomes and Liposomes

1972 • 161 citations

THE ISOLATION OF EGG PHOSPHATIDYL CHOLINE BY AN ADSORPTION COLUMN TECHNIQUE

1951 • 161 citations

X-ray Diffraction Studies on Nerve

1935 • 157 citations

Calorimetric Detection of a Membrane-Lipid Phase Transition in Living Cells

1970 • 154 citations

The effect of ultrasonic irradiation on the chemical structure of egg lecithin

1971 • 153 citations

Studies on the lysis of red cells and bimolecular lipid leaflets by synthetic lysolecithins, lecithins and structural analogs

1969 • 152 citations

The involvement of phosphatidylserine in adenosine triphosphatase activity of the sodium pump

1970 • 144 citations

The physical chemistry of phospholipids

1964 • 138 citations

Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides

1970 • 138 citations

Diffusion of Small Non-Electrolytes across Liposome Membranes

1972 • 134 citations

13C NMR Spectra of Lecithin Vesicles and Erythrocyte Membranes

1971 • 134 citations

Fractionation of naturally occurring lecithins according to degree of unsaturation by thin-layer chromatography

1965 • 130 citations

The analysis of tissue phospholipids: hydrolysis procedure and results with pig liver

1960 • 127 citations

The action of anaesthetics on phospholipid membranes

1969 • 127 citations

Ionic Properties of Aqueous Dispersions of Phosphatidic Acid

1964 • 123 citations

On the mechanism of non-electrolyte permeation through lipid bilayers and through biomembranes

1971 • 122 citations

The relation between the activity of a lecithinase and the electrophoretic charge of the substrate

1959 • 121 citations

The Action of Polyene Antibiotics on Phospholipid-Cholesterol Structures

1967 • 119 citations

Effect of cholesterol incorporation on the sensitivity of liposomes to the polyene antibiotic, filipin

1968 • 111 citations

Thin-layer chromatographic studies of human brain gangliosides

1966 • 109 citations

Biophysical properties of phospholipids. II. Permeability of phosphatidylserine liquid crystals to univalent ions

1966 • 108 citations

The effect of alterations in fatty acid composition and cholesterol content on the permeability of Mycoplasma laidlawii B cells and derived liposomes

1970 • 108 citations

The role of cholesterol in lipid membranes

1969 • 101 citations

Cation permeability of liposomes as a function of the chemical composition of the lipid bilayers

1971 • 100 citations

Effect of two brain specific proteins (S100 and 14.3.2) on cation diffusion across artificial lipid membranes

1971 • 96 citations

Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation

1958 • 95 citations

X‐ray diffraction studies of lipide emulsions

1941 • 95 citations

Selective diffusion of neutral amino acids across lipid bilayers

1971 • 93 citations

Physical studies of phospholipids. IX. Nuclear resonance studies of lipid-water systems

1968 • 93 citations

The distribution of phospholipase D in developing and mature plants

1969 • 92 citations

Determination of Urea Permeability in Red Cells by Minimum Method

1970 • 91 citations

Optical properties of black lecithin films

1969 • 88 citations

A light-scattering study of ultrasonically irradiated lecithin sols

1965 • 87 citations

A SIMPLE PROCEDURE FOR THE PREPARATION OF BRAIN SULPHATIDES*

1959 • 87 citations

Steroids and their interactions with phospholipids: Solubility, distribution coefficient and effect on potassium permeability of liposomes

1970 • 82 citations

Antagonism of Pressure and Anaesthesia

1970 • 82 citations

The simultaneous measurement of cell permeability to water and to dissolved substances

1933 • 80 citations

Comparison of double layer potentials in lipid monolayers and lipid bilayer membranes

1972 • 80 citations

Na+-K+ discrimination by “pure” phospholipid membranes

1971 • 79 citations

Water permeability of phospholipid vesicles

1970 • 79 citations

On the biochemical mechanism of the visual process

1967 • 74 citations

The Electrical Double Layer and Electrokinetic Phenomena

1964 • 74 citations

Surface and bulk interactions of lipids and water with a classification of biologically active lipids based on these interactions.

1970 • 71 citations

Mixtures of gangliosides and phosphatidylcholine in aqueous dispersions

1972 • 68 citations

Differential Calorimetry of Thermally Induced Processes in Solution

1967 • 66 citations

The binding of thyroid hormones to phospholipid membranes

1970 • 63 citations

Preparation and characteristics of lipid vesicles

1971 • 63 citations

Dielectric studies on homogeneous phosphatidylcholine vesicles

1972 • 58 citations

The osmotic insensitivity of sonicated liposomes and the density of phospholipid-cholesterol mixtures

1973 • 57 citations

Lyotropic Mesomorphism in Lipid-Water Systems

1969 • 55 citations

Purification and Properties of Bovine Factor X: Molecular Changes During Activation^*

1964 • 55 citations

Activation of glucose diffusion from egg lecithin liquid crystals by serum albumin

1969 • 55 citations

Liquid crystalline phases of hydrated phosphatidylethanolamine

1969 • 54 citations

The structure of dilute lecithin-water systems revealed by freeze-etching and electron microscopy

1969 • 54 citations

Physical studies of phospholipids VIII. Nuclear magnetic resonance studies of diacyl-l-phosphatidylcholines (lecithins)

1968 • 49 citations

Measurement of Transmembrane Potentials in Phospholipid Vesicles

1972 • 47 citations

Water extrusion in isolated subcellular fractions VI. Osmostic properties of swollen phospholipid suspensions

1967 • 47 citations

Versatile Stopped Flow Temperature Jump Apparatus

1966 • 44 citations

On the surface potentials of unimolecular films of long chain fatty acids.–Part I. Experimental method

1931 • 44 citations

Light scattering by phospholipid dispersions: Theory of light scattering by hollow spherical particles

1972 • 44 citations

A light-scattering study of lecithin

1960 • 43 citations

Ueber das Lecithin

1868 • 42 citations

The diffusion of ions from a phospholipid model membrane system

1967 • 41 citations

The Molecular Basis of Acute Gout

1971 • 41 citations

Nuclear relaxation (T1) measurements of lecithin-water systems

1971 • 40 citations

The Diffusion of Ions from a Phospholipid Model Membrane System

1967 • 40 citations

Studies on model membrane. I. Effects of Ca2+ and antibiotics on permeability of cardiolipin liquid-crystalline vesicles

1970 • 39 citations

19F NMR of monofluorostearic acids in lecithin vesicles

1971 • 38 citations

Control of Lecithinase Activity by the Electrophoretic Charge on its Substrate Surface

1958 • 37 citations

Nuclear Relaxation in Phospholipids and Biological Membranes

1970 • 37 citations

Model membranes: Spherical shells bounded by one bimolecular layer of phospholipids

1970 • 33 citations

Low-angle X-ray diffraction study of the polymorphic forms of synthetic α:β and α:α′-kephalins and α:β-lecithins

1955 • 32 citations

Blueprint records of thin-layer chromatograms

1964 • 32 citations

STUDIES ON ANIMAL LIPIDS

1936 • 32 citations

STUDIES ON ANIMAL LIPIDS

1940 • 31 citations

Electron microscopy of lipids: Effects of pH and fixatives on the appearance of a macromolecular assembly of lipid micelles in negatively stained preparations

1969 • 30 citations

The dispersion of cerebral lipids in aqueous media by ultrasonic irradiation

1964 • 29 citations

Osmotic volume changes induced by a permeable solute

1967 • 29 citations

Studies of Chlorophyll-Lipid-Water Systems

1968 • 29 citations

Identification of lamellar and hexagonal phases in negatively stained phospholipid-water systems

1971 • 27 citations

A simple method of determining relative permeabilities of liposomes to non-electrolytes

1972 • 26 citations

Model transport studies utilizing lecithin spherules

1972 • 24 citations

The effect of non-electrolyte osmolarity on frog oocytes

1971 • 24 citations

Mass spectrometry of the phosphatidyl amino alcohols: detection of molecular species and use of low voltage spectra and metastable scanning in the elucidation of structure

1972 • 24 citations

Application of the temperature-jump technique to the study of phospholipid dispersions

1970 • 18 citations

Chlorophyll a-containing liposomes

1970 • 18 citations

An interaction between oestradiol and progesterone in aqueous solutions and in a model membrane system

1971 • 18 citations

The consequences of inducing salt permeability in liposomes

1971 • 17 citations

Light scattering temperature jump relaxations in mixed solvent suspensions of phosphatidylcholine vesicles

1970 • 16 citations

Distillation and Storage of Water

1972 • 15 citations

Water extrusion in isolated subcellular fractions

1964 • 15 citations

A simple biochemical method for the preparation of high specific activity [14C]acyl-labelled phosphatidylcholine and other phospholipids

1972 • 12 citations

Lecithin-cholesterol Sols

1963 • 12 citations

The large-scale preparation of unsaturated phosphatidyl cholines from egg yolk

1970 • 11 citations

The structure of lysolecithin-water phases Negative staining and optical difraction analysis of the electron micrographs

1970 • 10 citations

Molecular Mechanism of Tay–Sachs Disease

1972 • 6 citations