Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.

Neurotoxicity and Elevated Cerebrospinal-Fluid Methotrexate Concentration in Meningeal Leukemia

1973 • 341 citations

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency.

1960 • 340 citations

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

1973 • 240 citations

Pharmacokinetics of methotrexate

1974 • 158 citations

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

1975 • 121 citations

Competitive protein binding assay for methotrexate.

1975 • 100 citations

Comparison of the Dose- and Time-Survival Curves for Normal Hematopoietic and Lymphoma Colony-Forming Cells Exposed to Vinblastine, Vincristine, Arabinosylcytosine, and Amethopterin<xref ref-type="fn" rid="FN2">2</xref>

1969 • 90 citations

The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects

1975 • 84 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

Enzymatic Cleavage of Methotrexate provides a Method for Prevention of Drug Toxicity

1972 • 67 citations

The Turnover of Folate Coenzymes in Murine Lymphoma Cells

1973 • 46 citations

Biochemical, biological, pharmacologic, toxicologic, kinetic and clinical (subhuman and human) relationships

1968 • 45 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.

1975 • 38 citations

Exchangeable intracellular methotrexate levels in the presence and absence of vincristine at extracellular drug concentrations relevant to those achieved in high-dose methotrexate-folinic acid "rescue" protocols.

1976 • 35 citations

Relative toxicity of methotrexate in several tissues of mice bearing Lewis lung carcinoma.

1974 • 34 citations

A direct ligand-binding radioassay for the measurement of methotrexate in tissues and biological fluids.

1975 • 27 citations