Increased Formation of Reactive Oxygen Species after Permanent and Reversible Middle Cerebral Artery Occlusion in the Rat

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model

1989 • 480 citations

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

1994 • 455 citations

Correlation between periinfarct DC shifts and ischaemic neuronal damage in rat

1993 • 400 citations

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1995 • 378 citations

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger.

1988 • 377 citations

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

1989 • 368 citations

The molecular basis of brain injury and brain edema

1990 • 355 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

The Molecular Basis of Brain Injury and Brain Edema: The Role of Oxygen Free Radicals

1990 • 321 citations

Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

1993 • 305 citations

Cortical Negative DC Deflections following Middle Cerebral Artery Occlusion and KCl-Induced Spreading Depression: Effect on Blood Flow, Tissue Oxygenation, and Electroencephalogram

1994 • 297 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

Role of Neutrophils in Radical Production during Ischemia and Reperfusion of the Rat Brain: Effect of Neutrophil Depletion on Extracellular Ascorbyl Radical Formation

1995 • 257 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics

1993 • 235 citations

The ischemic penumbra

1994 • 230 citations

Glutamate, calcium, and free radicals as mediators of ischemic brain damage

1995 • 201 citations

Cortical Spreading Depression Protects against Subsequent Focal Cerebral Ischemia in Rats

1996 • 169 citations

Diffusion nuclear magnetic resonance imaging in experimental stroke. Correlation with cerebral metabolites.

1994 • 164 citations

Pharmacology of cerebral ischemia

1995 • 163 citations

Global Cerebral Ischemia in the Rat: Online Monitoring of Oxygen Free Radical Production Using Chemiluminescence in vivo

1995 • 158 citations

Focal cerebral ischemia in the rat: Topography of hemodynamic and histopathological changes

1984 • 157 citations

Simultaneous Measurement of Salicylate Hydroxylation and Glutamate Release in the Penumbral Cortex following Transient Middle Cerebral Artery Occlusion in Rats

1996 • 127 citations

The Heat Shock/Stress Response in Focal Cerebral Ischemia

1994 • 114 citations

Perfusion Deficit Parallels Exacerbation of Cerebral Ischemia/Reperfusion Injury in Hyperglycemic Rats

1997 • 111 citations

Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors

1993 • 101 citations

Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion

1993 • 98 citations

Three-Dimensional Image Analysis of Brain Glucose Metabolism-Blood Flow Uncoupling and its Electrophysiological Correlates in the Acute Ischemic Penumbra following Middle Cerebral Artery Occlusion

1995 • 96 citations

The dissociation of cerebral blood flow, metabolism, and function in the early stages of developing cerebral infarction

1980 • 96 citations

Multiparametric Imaging of Blood Flow and Metabolism after Middle Cerebral Artery Occlusion in Cats

1985 • 92 citations

Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats.

1991 • 91 citations

A modified rat model of middle cerebral artery thread occlusion under electrophysiological control for magnetic resonance investigations

1995 • 88 citations

Detection of activated O2 species in vitro and in rat lungs by chemiluminescence

1989 • 86 citations

Liposome-mediated augmentation of brain SOD and catalase inhibits CNS O2 toxicity

1984 • 85 citations

Transient cell depolarization after permanent middle cerebral artery occlusion: An observation by diffusion‐weighted MRI and localized ¹H‐MRS

1994 • 78 citations

Microglial Response to Transient Focal Cerebral Ischemia: An Immunocytochemical Study on the Rat Cerebral Cortex Using Anti-Phosphotyrosine Antibody

1994 • 61 citations

Morphological Manifestations of Reperfusion Injury in Brain a

1994 • 50 citations

Morphological consequences of early reperfusion following thrombotic or mechanical occlusion of the rat middle cerebral artery

1989 • 48 citations