Reduced Paneth cell α-defensins in ileal Crohn's disease

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Inflammatory Bowel Disease

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Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

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Interactions between commensal intestinal bacteria and the immune system

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High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

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Mucosal flora in inflammatory bowel disease

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The Immunology of Mucosal Models of Inflammation

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Antibacterial peptides: basic facts and emerging concepts

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Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

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Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

2000 • 1,002 citations

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

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NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

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Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

1998 • 832 citations

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal -defensin expression

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Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum

1991 • 755 citations

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

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Dysbiosis in inflammatory bowel disease

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Wnt signalling induces maturation of Paneth cells in intestinal crypts

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The Genetics of Inflammatory Bowel Disease

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Bacterial contributions to mammalian gut development

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Crohn’s disease and the NOD2 gene: a role for paneth cells

2003 • 528 citations

Paneth cells of the human small intestine express an antimicrobial peptide gene

1992 • 525 citations

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

2005 • 477 citations

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium

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Paneth cell trypsin is the processing enzyme for human defensin-5

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The multifaceted Paneth cell

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The genetics of inflammatory bowel disease

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Sternberg's Diagnostic Surgical Pathology

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Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine

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Regulation of IL-8 and IL-1 expression in Crohn's disease associated NOD2/CARD15 mutations

2004 • 264 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

Endoscopic and histologic evaluation together with symptom assessment are required to diagnose pouchitis

2001 • 246 citations

Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria b bThe GenBank accession numbers for the clone sequences reported in this paper can be found in Table 1 T1 ; the accession number for isolate MIB-CB3 is AJ418059.

2002 • 246 citations

Human defensin gene copy number polymorphisms: Comprehensive analysis of independent variation in α- and β-defensin regions at 8p22–p23

2005 • 190 citations

Localization of human intestinal defensin 5 in Paneth cell granules

1997 • 188 citations

Clinical relevance of advances in genetics and pharmacogenetics of IBD

2004 • 184 citations

Mechanisms of Disease: defensins in gastrointestinal diseases

2005 • 164 citations

Crohn's disease

2003 • 149 citations

Paneth Cell Defensins and Innate Immunity of the Small Bowel

2001 • 141 citations

Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression

2003 • 135 citations

Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins

2000 • 131 citations

A 450-kb contig of defensin genes on human chromosome 8p23

1999 • 100 citations

Isolation of human intestinal defensins from ileal neobladder urine

1998 • 75 citations

Intestinal microflora in human and experimental inflammatory bowel disease

2001 • 75 citations

Genotypes and phenotypes in Crohn's disease: do they help in clinical management?

2004 • 62 citations

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence

2004 • 58 citations