The implications of human metabolic network topology for disease comorbidity

Emergence of Scaling in Random Networks

1999 • 34,466 citations

Network biology: understanding the cell's functional organization

2004 • 7,596 citations

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

2006 • 4,789 citations

The large-scale organization of metabolic networks

2000 • 4,250 citations

Evolution of networks

2002 • 3,190 citations

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

2004 • 3,142 citations

The human disease network

2007 • 3,104 citations

From genomics to chemical genomics: new developments in KEGG

2005 • 3,004 citations

Scale-Free Networks

2003 • 2,439 citations

Evolution of Networks

2003 • 1,497 citations

Global reconstruction of the human metabolic network based on genomic and bibliomic data

2007 • 1,390 citations

Scale-free networks in cell biology

2005 • 1,206 citations

An integrative genomics approach to infer causal associations between gene expression and disease

2005 • 1,047 citations

Genome-scale models of microbial cells: evaluating the consequences of constraints

2004 • 1,029 citations

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2001 • 1,000 citations

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2007 • 908 citations

Scale-Free Networks

2007 • 697 citations

Scale-free networks: complex webs in nature and technology

2008 • 615 citations

Human disease classification in the postgenomic era: A complex systems approach to human pathobiology

2007 • 586 citations

Getting connected: analysis and principles of biological networks

2007 • 560 citations

Interactome: gateway into systems biology

2005 • 400 citations

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2007 • 374 citations

Flux Coupling Analysis of Genome-Scale Metabolic Network Reconstructions

2004 • 371 citations

Probing genetic overlap among complex human phenotypes

2007 • 313 citations

The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis

2005 • 294 citations

Large Scale Structure and Dynamics of Complex Networks

2007 • 254 citations

Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues

2005 • 251 citations

Hierarchical thinking in network biology: the unbiased modularization of biochemical networks

2004 • 201 citations

Protein interactions and disease: computational approaches to uncover the etiology of diseases

2007 • 197 citations

Using Medicare Claims for Outcomes Research

1994 • 175 citations

Genetic Screening for Signal Transduction in the Era of Network Biology

2007 • 157 citations

The Activity Reaction Core and Plasticity of Metabolic Networks

2005 • 139 citations

COCCIDIOSIS IN GALLINACEOUS BIRDS

1932 • 135 citations

Biological impacts and context of network theory

2007 • 126 citations

Phenome connections

2008 • 99 citations

Epidemiologic Uses of Medicare Data

1993 • 85 citations

DISEASE GENE DISCOVERY THROUGH INTEGRATIVE GENOMICS

2005 • 84 citations

Expression dynamics of a cellular metabolic network

2005 • 83 citations

Systems biology of SNPs

2006 • 58 citations

Mouse phenogenomics: The fast track to “systems metabolism”

2005 • 49 citations

Elucidation and Structural Analysis of Conserved Pools for Genome-Scale Metabolic Reconstructions

2004 • 46 citations

Alternative Methods for Formal Literature Review and Meta-Analysis in AHCPR Patient Outcomes Research Teams

1994 • 35 citations

Obesity and diabetes

2006 • 23 citations

Optimal flux patterns in cellular metabolic networks

2007 • 15 citations