Hierarchical thinking in network biology: the unbiased modularization of biochemical networks

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Hierarchical Organization of Modularity in Metabolic Networks

2002 • 4,160 citations

From molecular to modular cell biology

1999 • 3,617 citations

The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

2002 • 1,805 citations

Evidence for dynamically organized modularity in the yeast protein–protein interaction network

2004 • 1,798 citations

Integrating high-throughput and computational data elucidates bacterial networks

2004 • 799 citations

Engineered gene circuits

2002 • 738 citations

Modular organization of cellular networks

2003 • 707 citations

Global organization of metabolic fluxes in the bacterium Escherichia coli

2004 • 701 citations

Reconstruction and Validation of Saccharomyces cerevisiae iND750, a Fully Compartmentalized Genome-Scale Metabolic Model

2004 • 650 citations

Network motifs in integrated cellular networks of transcription–regulation and protein–protein interaction

2004 • 547 citations

Prediction and measurement of an autoregulatory genetic module

2003 • 452 citations

Genome-scale microbial in silico models: the constraints-based approach

2003 • 408 citations

METATOOL: for studying metabolic networks.

1999 • 383 citations

Flux Coupling Analysis of Genome-Scale Metabolic Network Reconstructions

2004 • 371 citations

Metabolic pathways in the post-genome era

2003 • 364 citations

Motifs, modules and games in bacteria

2003 • 314 citations

Biochemical Pathways

2012 • 297 citations

A Test Case of Correlation Metric Construction of a Reaction Pathway from Measurements

1997 • 294 citations

Assessment of the Metabolic Capabilities of Haemophilus influenzae Rd through a Genome-scale Pathway Analysis

2000 • 232 citations

The complexity of complexes in signal transduction

2003 • 218 citations

Genome-Scale In Silico Models of E. coli Have Multiple Equivalent Phenotypic States: Assessment of Correlated Reaction Subsets That Comprise Network States

2004 • 212 citations

Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae

2002 • 209 citations

Energy Metabolism of the Cell: A Theoretical Treatise

1982 • 160 citations

Uniform Sampling of Steady-State Flux Spaces: Means to Design Experiments and to Interpret Enzymopathies

2004 • 150 citations

Extreme Pathway Lengths and Reaction Participation in Genome-Scale Metabolic Networks

2002 • 145 citations

The JAK-STAT Signaling Network in the Human B-Cell: An Extreme Signaling Pathway Analysis

2004 • 128 citations

Signaling Complexes: Junctions on the Intracellular Information Super Highway

2002 • 116 citations

NF-κB signaling in lymphocytes: a new cast of characters

2003 • 105 citations

MAP Kinase Modules: Many Roads Home

2003 • 104 citations

In silico biology through “omics”

2002 • 101 citations

Modular modeling of cellular systems with ProMoT/Diva

2003 • 99 citations

The Convex Basis of the Left Null Space of the Stoichiometric Matrix Leads to the Definition of Metabolically Meaningful Pools

2003 • 89 citations

Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?

2003 • 87 citations

Determining all extreme semi-positive conservation relations in chemical reaction systems: a test criterion for conservativity

1991 • 79 citations

Use of network analysis of metabolic systems in bioengineering

2002 • 73 citations

Description and Analysis of Metabolic Connectivity and Dynamics in the Human Red Blood Cell

2002 • 62 citations

Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks

1991 • 60 citations

Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks

1991 • 53 citations

Reducing complexity in metabolic networks: making metabolic meshes manageable.

1987 • 34 citations