Kaposi's Sarcoma-Associated Herpesvirus

Mechanisms of angiogenesis

1997 • 5,696 citations

Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma

1994 • 5,605 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Principles of CDK regulation

1995 • 3,267 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

AP-1 function and regulation

1997 • 2,833 citations

Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas

1995 • 2,833 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]

1995 • 2,169 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Localized mediastinal lymph-node hyperplasia resembling thymoma

1956 • 1,595 citations

Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)

1996 • 1,464 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Cloning the Differences Between Two Complex Genomes

1993 • 1,301 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus

1996 • 1,175 citations

Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV Infection

1995 • 1,093 citations

Lytic growth of Kaposi's sarcoma–associated herpesvirus (human herpesvirus 8) in culture

1996 • 1,043 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

D-type cyclins

1995 • 978 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma

1995 • 885 citations

Idiopathisches multiples Pigmentsarkom der Haut

1872 • 877 citations

KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma

1996 • 816 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma–associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission

1996 • 763 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells

1995 • 692 citations

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

1997 • 664 citations

Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells

1997 • 662 citations

Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen

1996 • 639 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae

1996 • 573 citations

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

1994 • 571 citations

In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences

1995 • 567 citations

Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients

1996 • 553 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

1997 • 479 citations

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma.

1996 • 465 citations

Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.

1994 • 460 citations

The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen

1997 • 447 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 • 437 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma

1996 • 396 citations

Establishment and characterization of a primary effusion (body cavity- based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus

1996 • 395 citations

Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors

1985 • 387 citations

The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

1996 • 382 citations

Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma

1995 • 380 citations

Toward the Primary Prevention of Cancer

1991 • 361 citations

KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway

1997 • 358 citations

Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

1989 • 355 citations

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

1997 • 352 citations

Angiogenic Properties of Kaposi's Sarcoma-Derived Cells After Long-Term Culture in Vitro

1988 • 335 citations

THE BIOCHEMISTRY OF AIDS

1991 • 332 citations

Kaposiʼs sarcoma-associated herpesvirus infection prior to onset of Kaposiʼs sarcoma

1996 • 330 citations

Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors

1993 • 323 citations

Cancer in Kampala, Uganda, in 1989–91: Changes in incidence in the era of aids

1993 • 321 citations

A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma

1995 • 308 citations

The Human Herpesviruses

1993 • 301 citations

EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus.

1994 • 298 citations

Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus

1989 • 297 citations

Human herpesvirus 8 encodes a homolog of interleukin-6

1997 • 296 citations

Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin

1997 • 291 citations

The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1

1997 • 288 citations

Primary Body Cavity-Based AIDS-Related Lymphomas

1996 • 270 citations

Molecular Basis of Virus Evolution

1995 • 269 citations

Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection

1996 • 266 citations

Kaposi's Sarcoma–Associated Herpesvirus DNA Sequences in Prostate Tissue and Human Semen

1996 • 263 citations

The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients.

1996 • 261 citations

Human Herpesvirus 8 Seroprevalence in Blood Donors and Lymphoma Patients From Different Regions of Italy

1998 • 260 citations

Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus

1989 • 254 citations

Epstein-Barr virus strategy in normal and neoplastic B cells

1994 • 251 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Frequent Detection of Kaposi's Sarcoma—Associated Herpesvirus (Human Herpesvirus 8) DNA in Saliva of Human Immunodeficiency Virus‐Infected Men: Clinical and Immunologic Correlates

1997 • 248 citations

Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions

1997 • 240 citations

Geographical and racial differences in the frequency of Kaposi's sarcoma as evidence of environmental or genetic causes.

1962 • 239 citations

Multicentric Castleman's disease

2000 • 236 citations

Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women

1996 • 235 citations

Identification of a Major Growth Factor for AIDS-Kaposi's Sarcoma Cells as Oncostatin M

1992 • 227 citations

KSHV and Kaposi's Sarcoma: The End of the Beginning?

1997 • 223 citations

Angiogenic properties of human immunodeficiency virus type 1 Tat protein.

1995 • 220 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Herpes-Type Virus Particles in Tissue Culture of Kaposi's Sarcoma From Different Geographic Regions2

1972 • 214 citations

Visualization of human herpesvirus type 8 in Kaposiʼs sarcoma by light and transmission electron microscopy

1997 • 209 citations

Kaposi's sarcoma-associated herpesvirus in non-AIDS related lymphomas occurring in body cavities.

1996 • 207 citations

The feasibility of targeted selective gene therapy of the hair follicle

1995 • 203 citations

Kaposi's sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV infection

1996 • 199 citations

Establishing a KSHV+ Cell Line (BCP-1) From Peripheral Blood and Characterizing Its Growth in Nod/SCID Mice

1998 • 199 citations

Kaposi's sarcoma‐associated herpesvirus DNA sequences in AIDS‐related and AIDS‐unrelated lymphomatous effusions

1996 • 196 citations

Comparative genomic analysis of tumors: detection of DNA losses and amplification.

1995 • 181 citations

A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins

1997 • 170 citations

Kaposi sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease: is there any relevant association in non-human immunodeficiency virus-infected patients? [letter; comment]

1996 • 157 citations

HIV-tat protein is a heparin-binding angiogenic growth factor.

1996 • 152 citations

DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.

1987 • 151 citations

Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome.

1999 • 146 citations

Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis

1995 • 145 citations

Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice.

1995 • 138 citations

The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

The Natural History and Molecular Heterogeneity of HIV-Associated Primary Malignant Lymphomatous Effusions

1996 • 136 citations

Kaposi sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease: is there any relevant association in non-human immunodeficiency virus-infected patients? [letter; comment]

1996 • 132 citations

Antibody patterns to herpesviruses in kaposi's sarcoma: Serological association of european kaposi's sarcoma with cytomegalovirus

1975 • 129 citations

HPV-16-related DNA sequences in Kaposi's sarcoma

1992 • 128 citations

Expanding horizons for receptors coupled to G proteins: diversity and disease

1994 • 127 citations

Herpesvirus-like DNA sequences detected in endemic, classic, iatrogenic and epidemic Kaposi's sarcoma (KS) biopsies

1996 • 125 citations

Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls [see comments]

1994 • 124 citations

Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors

1997 • 118 citations

The D-type cyclins and their role in tumorigenesis

1994 • 116 citations

Regulation of the interferon system and cell growth by the IRF transcription factors

1995 • 115 citations

Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients.

1996 • 114 citations

Diagnosis of Malignant Lymphoma in Effusions from Patients with AIDS by Gene Rearrangement

1990 • 113 citations

Cyclin D1 as a cellular proto-oncogene

1995 • 111 citations

The spindle-shaped cells in cutaneous Kaposi's sarcoma. Histologic simulators include factor XIIIa dermal dendrocytes.

1989 • 110 citations

AGGRESSIVE KAPOSI'S SARCOMA IN ZAMBIA, 1983

1984 • 110 citations

Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in angiosarcoma.

1996 • 107 citations

Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions.

1996 • 105 citations

Establishing a KSHV+ Cell Line (BCP-1) From Peripheral Blood and Characterizing Its Growth in Nod/SCID Mice

1998 • 104 citations

Characterization of a Chemokine Receptor-Related Gene in Human Herpesvirus 8 and Its Expression in Kaposi's Sarcoma

1997 • 104 citations

Detection of HHV-8/KSHV DNA sequences in AIDS-associated extranodal lymphoid malignancies.

1996 • 101 citations

An AIDS-Like Condition Induced in Baboons by HIV-2

1994 • 101 citations

Epidemiology of Classic Kaposi's Sarcoma, with Special Reference to Mediterranean Population

1995 • 100 citations

Molecular analysis of clonality in Kaposi's sarcoma.

1997 • 98 citations

Expression of the Chemokine Receptor BLR2/EBI1 Is Specifically Transactivated by Epstein-Barr Virus Nuclear Antigen 2

1995 • 93 citations

Body Cavity-Based Malignant Lymphoma Containing Kaposi Sarcoma-Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma

1996 • 91 citations

How viral oncogenes make the cell cycle

1996 • 89 citations

Restricted Tissue Distribution of Extralesional Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences in AIDS Patients with Kaposi's Sarcoma

1996 • 84 citations

Latent BK virus infection and Kaposi's sarcoma pathogenesis

1996 • 80 citations

Frequent Presence of a Novel Herpesvirus Genome in Lesions of Human Immunodeficiency Virus-Negative Kaposi's Sarcoma

1996 • 79 citations

Detection of Kaposi’s Sarcoma-associated Herpesvirus-like DNA Sequence in Vascular Lesions:A Reliable Diagnostic Marker for Kaposi’s Sarcoma

1996 • 76 citations

Kaposi's Sarcoma: A Review of Gene Expression and Ultrastructure of KS Spindle Cells In Vivo

1992 • 74 citations

Birthplace and Classic Kaposi's Sarcoma in Italy

1995 • 65 citations

Endemic Kaposi's Sarcoma in Human Immunodeficiency Virus Type 1–Seronegative Persons: Demonstration of Retrovirus-Like Particles in Cutaneous Lesions

1990 • 64 citations

Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220

1996 • 59 citations

Detection of Human Herpesvirus 8 and Human T-Cell Lymphotropic Virus Type 1 Sequences in Kaposi Sarcoma

1997 • 57 citations

Prevalence of human herpesvirus 8 DNA sequences in several patient populations

1996 • 57 citations

Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src

1997 • 48 citations

Frequency and distribution of herpesvirus-like DNA sequences (KSHV) in different stages of classic Kaposi's sarcoma and in normal tissues from an Italian population

1996 • 42 citations

Human herpesvirus type 6 and cytomegalovirus in AIDS-associated Kaposi's sarcoma: No evidence for an etiological association

1995 • 38 citations

Lymphotropic herpes virus (EBV, HHV-6, HHV-8) DNA sequences in HIV negative Castleman's disease

1996 • 34 citations

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

1996 • 33 citations

Expression of Epstein‐Barr virus nuclear antigen‐2 (EBNA2) induces CD21/CR2 on B and T cell lines and shedding of soluble CD21

1995 • 32 citations

Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.

1996 • 29 citations

Herpes virus-like sequences are specifically found in Kaposi sarcoma lesions.

1996 • 26 citations

Cancer, HIV and AIDS

1992 • 23 citations

Origins of DNA viruses

1995 • 8 citations

Morbid Effects of Dentition

1828 • 2 citations